TWiV 1042: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization, temporal changes in fecal microbiota of patients infected with C...
Source: This Week in Virology - MP3 Edition - September 9, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

SCCM Pod-489 The AIMS Trial: Battle of the Bundles, Hour-1 Versus 3-Hour
The Assessment of Implementation of Methods in Sepsis and Respiratory Failure (AIMS) Study seeks to determine the safest and most effective approach to sepsis intervention using the evidence-based Surviving Sepsis Campaign guidelines. Marylin N. Bulloch, PharmD, BCPS, FCCM, was joined by Mitchell M. Levy, MD, MCCM, at the 2023 Critical Care Congress to discuss the goal of the AIMS Study and the elements of both the Hour-1 and 3-Hour bundles. Dr. Levy is chief of the Division of Critical Care, Pulmonary, and Sleep Medicine and professor of medicine at the Warren Alpert Medical School of Brown University. He is also the medi...
Source: SCCM PodCast - iCritical Care - August 30, 2023 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts

TWiV 1030: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the use of RSV vaccines in older adults: recommendations of the advisory committee on immunization practices, case report of leprosy in Central Florida, blood group A enhances SARS-CoV-2 infection, predicting COVID-19 incidence using wastewater surveillance data, a common allele of HLA associated with asymptomatic SARS-CoV-2 infection, prevalence of low-frequency, antiviral resistance variants in SARS-CoV-2 isolates in Ontario, Canada, viral resistance analyses from the Remdesivir phase 3 adaptive COVID-19 treatment trial-1, impact of Molnupiravir treatment on patient-r...
Source: This Week in Virology - MP3 Edition - July 29, 2023 Category: Virology Authors: VIncent Racaniello Source Type: podcasts

TWiV 1028: Asymptomatic SARS-CoV-2 infection and T cells
TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA that mediates asymptomatic SARS-CoV-2 infection through pre-existing T cell immunity due to previous exposure to common cold coronaviruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server First gene therapy for hemophilia A approved (FDA) Lux...
Source: This Week in Virology - MP3 Edition - July 23, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 1020: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses guidance on measles during the summer travel season, the Infectious Diseases Society of America guidelines on the diagnosis of COVID-19: antigen testing, SARS-CoV-2 variants and age-dependent infection rates among household and nonhousehold contacts, effect of COVID-19 vaccination on household transmission of SARS-COV-2 in the Omicron era, incidence of myopericarditis after mRNA COVID-19 vaccination, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong, safety, immunogenicity and protection of heterol...
Source: This Week in Virology - MP3 Edition - July 1, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Can tests for inflammation help doctors decide whether to use antibiotics for airway infections?
Acute respiratory infections are one of the most common reasons for people to present to primary care and decisions about whether or not to prescribe antibiotics might rely on point-of-care tests for inflammation. The relevant Cochrane review was updated in October 2022 and we asked new lead author, Siri Aas Smedemark from Odense University Hospital in Denmark, to tell us more in this podcast. (Source: Podcasts from The Cochrane Library)
Source: Podcasts from The Cochrane Library - May 22, 2023 Category: General Medicine Authors: Cochrane Source Type: podcasts

SCCM Pod-478: Challenges of Ill-Fitting Noninvasive Interfaces for Pediatric Patients
Although the variety of noninvasive interfaces for pediatric patients has grown in the past 10 years, they are still limited. Pediatric interfaces are typically scaled down from adult to child sizes, which does not consider the contours of a growing child’s face, causing poor fit in patients of certain ages. Donald S. Prough, MD, FCCM, was joined by Natalie Napolitano, MPH, RRT-NPS, during the 2023 Critical Care Congress to discuss how clinicians’ need to have the right equipment for their patients led to a device development project using 3D imaging that obtained sample sizes from various age groups to bridge the fit ...
Source: SCCM PodCast - iCritical Care - May 9, 2023 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts

TWiV 1004: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the U.S. Food and Drug Administration approving Arexvy: the first respiratory syncytial virus (RSV) vaccine approved for use in the United State, association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market, researchers disagree over how bad it is to be reinfected and whether COVID-19 can cause lasting changes to the immune system, virtual care and emergency department use during the COVID-19 pandemic among patients of family physicians in Canada, vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among healt...
Source: This Week in Virology - MP3 Edition - May 6, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

SCCM Pod-477: Going Viral With the Discovery VIRUS COVID-19 Registry
The Viral Infection and Respiratory Illness Universal Study (VIRUS) is a prospective, cross-sectional, observational study and registry of all eligible adult and pediatric patients who are admitted to a hospital. Marilyn N. Bulloch, PharmD, BCPS, FCCM, was joined by Rahul Kashyap, MD, MBA, at the 2023 Critical Care Congress to discuss the Discovery VIRUS COVID-19 Registry. Dr. Kashyap is an assistant professor and clinical research scientist at Mayo Clinic in Rochester, Minnesota, USA. (Source: SCCM PodCast - iCritical Care)
Source: SCCM PodCast - iCritical Care - May 1, 2023 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts

TWiV 996: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample, maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization, association of treatment with Nirmatrelvir and the risk of Post–COVID-19 condition, mechanically ventilated patients with COVID-19 had a higher chance of in-hospital death if treated with high-flow nasal cannula oxygen before intubation, high-f...
Source: This Week in Virology - MP3 Edition - April 1, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 989: Antibody cross-reactivity is metal
TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Paul Berg obituary •Spike mRNA in blood (J Path Micro Imm) •Spike mRNA in blood (Biomedicine) •Cross-protective mAbs against respiratory viruses (Nat Comm) •RSV prefusion F protein vaccine in older adults (NEJM) •Ad26.RSV.preF–RSV preF protein vaccine (NEJM) •Let...
Source: This Week in Virology - MP3 Edition - March 5, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 988: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six ch...
Source: This Week in Virology - MP3 Edition - March 4, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Talk Evidence - masks, chronic pain, and baby milk formulae claims
In this episode of Talk Evidence, Helen Macdonald is joined by Juan Franco and Joe Ross, to bring you the newest evidence in The BMJ. First, chronic pain. As prescribers move away from opioids, Juan finds an overview of systematic reviews asking whether anti-depressants might help. Joe finds new research on the link between six healthy lifestyle markers and cognitive decline. Helen looks at a trial to reduce prescribing among older people with suspected urinary tract infection or UTI. Juan has a nuanced take on the updated evidence on masks to reduce the spread of respiratory viruses. Finally, an international grou...
Source: The BMJ Podcast - February 24, 2023 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts

Talk Evidence - masks, chronic pain, and baby milk formulae claims
In this episode of Talk Evidence, Helen Macdonald is joined by Juan Franco and Joe Ross, to bring you the newest evidence in The BMJ. First, chronic pain. As prescribers move away from opioids, Juan finds an overview of systematic reviews asking whether anti-depressants might help. Joe finds new research on the link between six healthy lifestyle markers and cognitive decline. Helen looks at a trial to reduce prescribing among older people with suspected urinary tract infection or UTI. Juan has a nuanced take on the updated evidence on masks to reduce the spread of respiratory viruses. Finally, an international grou...
Source: The BMJ Podcast - February 24, 2023 Category: General Medicine Authors: BMJ Group Source Type: podcasts

Talk Evidence - Milk, masks, pregnancy, and chronic pain
In this episode of Talk Evidence, Helen Macdonald is joined by Juan Franco and Joe Ross, to bring you the newest evidence in The BMJ. First, chronic pain. As prescribers move away from opioids, Juan finds an overview of systematic reviews asking whether anti-depressants might help. Joe finds new research on the link between six healthy lifestyle markers and cognitive decline. Helen looks at a trial to reduce prescribing among older people with suspected urinary tract infection or UTI. Juan has a nuanced take on the updated evidence on masks to reduce the spread of respiratory viruses. Finally, an international grou...
Source: The BMJ Podcast - February 24, 2023 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts