Talk Evidence - Milk, masks, pregnancy, and chronic pain
In this episode of Talk Evidence, Helen Macdonald is joined by Juan Franco and Joe Ross, to bring you the newest evidence in The BMJ. First, chronic pain. As prescribers move away from opioids, Juan finds an overview of systematic reviews asking whether anti-depressants might help. Joe finds new research on the link between six healthy lifestyle markers and cognitive decline. Helen looks at a trial to reduce prescribing among older people with suspected urinary tract infection or UTI. Juan has a nuanced take on the updated evidence on masks to reduce the spread of respiratory viruses. Finally, an international grou...
Source: The BMJ Podcast - February 24, 2023 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts

TWiV 982: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies, bacillu...
Source: This Week in Virology - MP3 Edition - February 11, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 908: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses prevalence and clinical outcomes of respiratory syncytial virus versus influenza virus in adults hospitalized with acute respiratory Illness, reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection postvaccination for mild COVID-19 patients, assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US, information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 Infection in the context of currently circulating Omicron sublineages, association of c...
Source: This Week in Virology - MP3 Edition - February 4, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 978: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe dis...
Source: This Week in Virology - MP3 Edition - January 28, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Loop Diuretics for Heart Failure, Oxygen Therapy Strategies for Children With Acute Hypoxemic Respiratory Failure, Review of Surgical Site Infection Prevention, and more
Editor’s Summary by Mary McGrae McDermott, MD, Deputy Editor of JAMA, the Journal of the American Medical Association, for the January 17, 2023, issue. Related Content: Audio Highlights (Source: JAMA: This Week's Audio Commentary)
Source: JAMA: This Week's Audio Commentary - January 17, 2023 Category: General Medicine Authors: JAMA Network Source Type: podcasts

SCCM Pod-468: When Should Antibiotics Be Used to Treat Respiratory Infections?
Although only a small number of patients hospitalized with COVID-19 present with a secondary bacterial pneumonia, a large percentage are unnecessarily treated with antibiotics. Pamela M. Peeke, MD, MPH, FACP, FACSM, is joined by George Sakoulas, MD, to discuss how physicians and hospitalists can identify when antibiotics are unnecessary for hospitalized patients with moderate to severe respiratory infections. Dr. Sakoulas is chief of infectious disease at Sharp Rees-Stealy Medical Group in San Diego, California, and an adjunct professor in the Division of Host-Microbe Systems and Therapeutics Center for Immunity, Infection...
Source: SCCM PodCast - iCritical Care - December 27, 2022 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts

SCCM Pod-448 Noninvasive Respiratory Support: Opinion- or Evidence-Based Medicine?
When should clinicians intubate preterm infants? The answer is not always straightforward, according to podcast guest Deepak Jain, MD, FAAP. He and host Pamela M. Peeke, MD, MPH, FACP, FACSM, discuss strategies that optimize noninvasive ventilation and when such strategies are appropriate. (Source: SCCM PodCast - iCritical Care)
Source: SCCM PodCast - iCritical Care - December 21, 2022 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts

TWiV 958: Pass the RNA and have some venison pi
The TWiV team reveals a variant SARS-CoV-2 that emerged in deer with deer-to-human transmission, and hybrid virus particles produced by co-infection with influenza virus and respiratory syncytial virus particles. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Testing and evaluation specialist (Harris County Public Health) Oveta Fuller tribute (YouTube) Divergent SARS-CoV-2 in deer (...
Source: This Week in Virology - MP3 Edition - November 27, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 956: A domesticated viral envelope with Cedric Feschotte and John Anthony Frank
Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Cedric Feschotte and John Anthony Frank Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Cedric on TWiV 935 Antiviral retroviral protein (Science) Stealing genes, facing consequences (Science) Letters read on TWiV 956 Timestamps by Jol...
Source: This Week in Virology - MP3 Edition - November 20, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 955: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccina...
Source: This Week in Virology - MP3 Edition - November 19, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 954: Speculating sarbecovirus spillovers with Michael Letko
Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker Guest: Michael Letko Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Cell entry of SARS-CoV-2 and other sarbecoviruses (Nat Micro) ACE2-dependent sarbecovirus in Rus...
Source: This Week in Virology - MP3 Edition - November 13, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 941: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, inter...
Source: This Week in Virology - MP3 Edition - October 1, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 936: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 an...
Source: This Week in Virology - MP3 Edition - September 17, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 924: TWiV clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection,  if repeat administration of casirivimab and imdevimab is well-tolerated, viral and symptom rebound in untreated infection, extended Remdesivir infusion for persistent infection, Baricitinib in patients admitted with infection, and cognitive impa...
Source: This Week in Virology - MP3 Edition - August 6, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts