Does a Single Troponin below the 99th percentile URL Rule out Acute MI if the Chest pain is very prolonged?
A 66 y.o. male who presented for chest pain that started this AM when he woke up, and has persisted throughout the day prompting him to call 911. He says the pain is dull in nature and located across the chest, does not radiate, that it isworse with exhalation. He denies worsening with activity or positioning. He endorses SOB and requested to sit up. He says this has not happened to him before. He endorses cough productive of yellow sputum. He denies any edema. Denies history of venous thromboembolism. He endorses a 50 pack year history of smoking. He denies recent illness or recent s...
Source: Dr. Smith's ECG Blog - May 26, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs
Case of the Week 683
Answer to Case 683:Cryptosporidiumsp. oocystsThe following OUTSTANDING discussion is from our guest author, Hadel Go, a third year medical student with a strong interest in clinical parasitology._________________________________________We received some excellent feedback! Thank you all for leaving comments on the blog, on Twitter, and on LinkedIn.Yes, these areCryptosporidium oocysts. These protozoans can be identified by their size and consistent red color on modified acid-fast staining of stool samples. They can also be diagnosed from H&E stained tissue biopsies (see images here:Cryptosporidium, parasitewonders.com),...
Source: Creepy Dreadful Wonderful Parasites - May 22, 2022 Category: Parasitology Source Type: blogs
Are You a Warm Demander? | TAPP 115
We once again revisitdeadline extensions, we discusswarm demanders and how they avoidtoxic rigor, we discoverwhich arm is best for a vaccine booster, we find out if we cangrow new auditory hair cells, we get tips on how tospeak more effectively while wearing a mask, and learn about a new discovery aboutoxygen absorption in the intestines. Can we breathe through our anus? Listen to find out!00:00 | Introduction01:02 | Growing New Auditory Hair Cells06:19 | Mask Talk: Loud, Slow,& Clear11:17 | Sponsored by AAA12:21 | Which Arm for That Booster?15:32 | Intestinal Breathing19:40 | Sponsored by HAPI21:03 | Deadlines, ...
Source: The A and P Professor - May 17, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, May 16th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 15, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
γδ T cells are Involved in the Generation of Chronic Inflammation by Excess Visceral Fat
Visceral fat around the inner organs is a metabolically active tissue, and more of it is entirely detrimental to long-term health. These fat deposits interact with the immune system in a number of distinct ways to produce chronic inflammation, and that inflammation in turn drives the onset and progression of tissue dysfunction and all of the common age-related conditions. For example, visceral fat encourages the accumulation of senescent cells and their pro-inflammatory signaling, while visceral fat cells signal in ways that mimic infection, as well as producing DNA debris that activates the innate immune system. Given the...
Source: Fight Aging! - May 9, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Another deadly and confusing ECG. Are you still one of the many people who will be fooled by this ECG, or do you recognize it instantly?
Submitted and written byDestiny Folk MD, peer reviewed by Meyers, Smith, Grauer, McLarenA man in his early 30s with no significant past medical history was brought to the ED by EMS after being found unresponsive by a friend. EMS arrived and found him awake and alert. He complained of generalized weakness and left lower extremity numbness. He reported that 12 hours prior to arrival he used fentanyl and cocaine. He reported difficulty walking and felt as if his left leg was “asleep.” He denied any chest pain or shortness of breath and stated he felt at his baseline yesterday prior to drug use. On arrival in the ED, he wa...
Source: Dr. Smith's ECG Blog - May 5, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
COVID-Related Skin Injuries
Thankfully the worst of the COVID-19 pandemic is over, but there is no doubt that the public health crisis brought new challenges to the wound care world. There has been profound impact upon caregivers and patients, including the epidemiology of skin lesions such as pressure injuries. The reverberations of the pandemic are still lingering, and this post will call attention to major concerns.
Impact of COVID-19 on Pressure Injury Epidemiology
The impact of SARS-CoV-2 on the occurrence of pressure injuries is substantial. Patients with severe respiratory disease and extended ICU admissions while on life support such as v...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - May 3, 2022 Category: Geriatrics Authors: Jeffrey M Levine Tags: Featured Medical Articles Geriatric Medicine Pressure Injuries & Wound Care bedsores coronavirus COVID COVID-19 decubiti decubitus ulcer Healthcare Quality Improving Medical Care pandemic pressure sore pressure sores pressure u Source Type: blogs
Case of the Week 680
This week ' s case is from Drs. Harsha Sheorey and Lauren McShane from Australia. The following were seen in bronchial washings from an immunocompromised patient (fluorescent prep for fungi and wet preps):Here are the blood culture plates from the bronchial washings.The patient also has Gram negative bacteremia. Diagnosis? As a bonus, what forms are we seeing in the respiratory specimens? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - May 2, 2022 Category: Parasitology Source Type: blogs
Flu Is Making Comeback. Here ’s What We Can Do About It
Jeffrey A. SingerAfter being nearly absent in 2020 and 2021, influenza cases are making a comeback. In fact, cases are up ‐tickingunusually late in the year. The Centers for Disease Control and Prevention (CDC)reported on April 15 that the majority of cases are H3N2, “antigenically different from the vaccine reference viruses.” This explains why the latest flu vaccine is only16 percent effective in reducing the chances of a moderate to severe infection. As of April 15, the CDC reported at least 4.3 million flu illnesses, 42,000 hospitalizations, and 2,500 deaths from the flu.Public health experts attribu...
Source: Cato-at-liberty - April 18, 2022 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More on the Safe Mitochondrial Uncoupling Compound BAM15
In this study, the aged mice increased their muscle mass by an average of 8 percent, their strength by 40 percent, while they lost more than 20 percent of their fat."
BAM15 improves many of the key determinants of health and aging, including: (a) removing damaged mitochondria, the power plants of the cell; (b) making more healthy mitochondria, and; (c) reducing "inflammaging," or age-related inflammation, linked to muscle loss.
Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control
Sarcopenic obesity is a highly prevalent disease with poor ...
Source: Fight Aging! - April 13, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Extracellular Vesicles to Protect Lungs and Brain in Premature Birth
Researchers at the Ottawa Hospital in Canada have been investigating the potential of extracellular vesicles that are derived from umbilical cord mesenchymal stromal cells (MSCs) to protect the lungs and brain in very premature babies. Such babies require supplemental oxygen, but this can damage their lungs, causing a condition called bronchopulmonary dysplasia (BPD). In the meantime their brains are also at risk because of low oxygen. These researchers have been investigating the potential of MSCs to help protect and regenerate such tissues, and a recent study in mice suggests that extracellular vesicles from such cells c...
Source: Medgadget - April 5, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Ob/Gyn Pediatrics ottawahospital Source Type: blogs
Welcome To The Virtual Ward!
The expression ‘virtual ward’ is trending. But is it just the expression we hear about more often, or is there a real trend? And by the way: what is a virtual ward? And what is it good for?
It is yet difficult to find one, generally accepted definition for the new phenomenon. The same phrase is used for a number of quite different solutions. For the sake of understanding, here is what we think about when we speak of virtual wards.
“A virtual ward is a solution that supports patients who would otherwise be in hospital to get the acute care, remote monitoring and treatment in their own homes, with the use o...
Source: The Medical Futurist - April 5, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine Digital Health Research E-Patients Future of Medicine Health Sensors & Trackers Healthcare Policy Telemedicine & Smartphones virtual ward Source Type: blogs
Managing healthcare staff with symptoms of a respiratory infection or a positive Covid-19 test result
UK Health Security Agency -This guidance is for staff and managers in health care settings and includes guidance for patient-facing health care staff if they develop symptoms of a respiratory infection including coronavirus (Covid-19), receive a positive Covid-19 test result, or are a contact of a confirmed case of Covid-19.GuidanceUK Health Security Agency - publications (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - April 1, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: Covid-19 Workforce and employment Source Type: blogs
Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
