Partially Inhibiting Mitochondrial Complex I as an Approach to Therapy
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 21, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 21st 2022
This study was the first to examine how these networks interact with physical activity and fitness to impact how the brain functions.
"This paper is exciting because it gives us some evidence that when people whose brain networks aren't functioning optimally engage in physical activity, we see improvement in their executive function and their independence. Maybe just take the stairs on the way to work. Stand up and walk around a little bit more. That's where you get the most bang for your buck, not crazy, high-intensity exercise."
Variations in Biological Age Across Organs in Younger Individuals
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Source: Fight Aging! - March 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Role of Mitochondrial DNA Mutation in Aging Remains Much Debated
Mitochondria are the power plants of the cell, deeply integrated into many core cellular processes, but most importantly, responsible for generating the energy store molecule adenosine triphosphate (ATP), used to power cellular processes. Mitochondria are descended from ancient symbiotic bacteria, and act like bacteria in many ways, fusing and dividing, and passing around component parts promiscuously. Every cell contains a herd of hundreds of these organelles, monitored by quality control processes that destroy worn mitochondria in order to maintain overall function.
Importantly, mitochondria contain their own smal...
Source: Fight Aging! - March 18, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing the Mechanisms that Allow Senescent Cells to Resist Apoptosis
A large portion of research into senescent cells in the context of degenerative aging is focused on how these cells fail to destroy themselves. Senescent cells are primed to enter the programmed cell death process of apoptosis, but various mechanisms hold this off. Sabotaging some of those mechanisms is an effective way to clear a sizable fraction of senescent cells in many old tissues, as demonstrated by the initial small molecule senolytic treatments, such as the dasatinib and quercetin combination.
As the authors of today's open access paper note, the fact that these apoptosis-inducing senolytics are only partial...
Source: Fight Aging! - March 16, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Mitochondrial DNA Mutation as a Contributing Cause of Aging, and the Prospects for Therapies
Mitochondria are the power plants of the cell. They are deeply integrated into many core cellular processes, but their primary responsibility is to generate adenosine triphosphate (ATP), an energy store molecule used to power cellular activities. Mitochondria are the evolved descendants of ancient symbiotic bacteria, and carry a small remnant genome encoding a handful of genes vital to ATP production. Each cell contains hundreds of mitochondria. Worn mitochondria are destroyed by the quality control process of mitophagy, while other mitochondria replicate much like bacteria to make up numbers.
The mitochondrial geno...
Source: Fight Aging! - March 15, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
5 Ways Digital Health Can Help Decarbonise Patient Pathways
In its lead-up to the 2021 United Nations Climate Change Conference (COP26), the WHO issued the ‘The Health Argument for climate action’ report. In it, the organisation shares its recommendations for governments on how to “maximise the health benefits of tackling climate change in order to avoid the worst health impacts of the climate crisis.”
A recent analysis found that globally, healthcare’s carbon footprint accounts for around 4-5% of total global carbon dioxide emissions. These are not insignificant figures and are the reason why the WHO is pushing for a more environmentally-sustainable approach to health...
Source: The Medical Futurist - March 10, 2022 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Forecast Digital Health Research healthcare systems sustainability climate crisis decarbonising patient pathways Source Type: blogs
Injected Nicotinamide Riboside Upregulates NAD+ in Mice, But Metabolic Effects are Minimal
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Link: https://doi.org/10.1016/j.isci.2022.103863 (Source: Fight Aging!)
Source: Fight Aging! - March 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Long Term Data on Particulate Air Pollution and Dementia in a US Population
There is plenty of evidence for particulate air pollution to have a negative effect on long-term health, particularly those derived from Asian populations that are exposed to more coal and wood smoke than tends to be the case in the US and Western Europe. While the relative importance of the various mechanisms involved are up for debate, the most plausible are those involving raised inflammation as a result of interactions between particles and lung tissue. The chronic inflammation of aging drives near all age-related conditions, and more inflammation means more dysfunction.
As researchers note here, not all particu...
Source: Fight Aging! - March 7, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 7th 2022
This study estimates that prescreening with a 500 blood test could reduce by half both the cost and the time it takes to enroll patients in clinical trials that use PET scans. Screening with blood tests alone could be completed in less than six months and cut costs by tenfold or more, the study finds. Known as Precivity AD, the commercial version of the test is marketed by C2N Diagnostics. The current study shows that the blood test remains highly accurate, even when performed in different labs following different protocols, and in different cohorts across three continents.
xCT Knockout Modestly Extends Life in M...
Source: Fight Aging! - March 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An elderly woman with shortness of breath and an ECG that helps understand it
Written by Pendell Meyers, edits by Smith and GrauerOne of my fantastic residents brought me an ECG on shift and asked for my interpretation without any context:What do you think?I responded that it looks like chronic right ventricular hypertrophy. This is due to the QRS morphology and axis including incomplete RBBB pattern in V1, precordial R wave progression reversal, matching deep S waves in leftward leads I and aVL, very rightward limb lead axis including R wave in aVR. See Ken Grauer ' s comments below where he points out that the tall P-wave in lead II is diagnostic of right atrial enlargement, which supp...
Source: Dr. Smith's ECG Blog - March 6, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
TWiV 872: COVID-19 clinical update #104 with Dr. Daniel Griffin
In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID. (Source: virology blog)
Source: virology blog - March 5, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
Arguing for a Rate of Living View of Aging
The rate of living view of aging is one of the discarded historical hypotheses that occurred along the way to the modern competing ideas about why aging occurs, and why there are differences in longevity between species. Roughly, the rate of living hypothesis says that a faster metabolism means a shorter life, that underlying processes (such as accumulation of molecular damage) depend strongly on metabolic rate. This doesn't appear to be the case, however; setting aside more detailed considerations, there are enough exceptions to the rule, species with high metabolism and exceptional longevity, to sink the argument. It isn...
Source: Fight Aging! - March 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Next-Generation Simulation Learning: Interview with James Archetto, VP of Gaumard Scientific
Gaumard Scientific, a Florida-based patient simulator company, has developed an advanced multidisciplinary patient simulator – the HAL S5301. Given the strain placed on healthcare systems by the pandemic, training with a robot may let more clinicians focus on patients rather than medical students, and help to reduce the risk of viral transmission posed to healthcare staff and patients.
However, there are a host of other benefits. This next-generation adult male simulator introduces robotics, AI-powered speech, and leading-edge simulated physiology and anatomy to medical education. The robot can understand what med...
Source: Medgadget - February 23, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Education Exclusive Source Type: blogs
‘Just Follow the Science’ Shows Some Improvement
Peter Van DorenDuring summer 2020 I wrote anessay about what science can and cannot do and the role it can play in public policy decisions including those pertaining to the COVID-19 pandemic. I concluded that science explains relationships between cause and effect: no more and no less. No normative conclusions about individual or collective decisions follow directly from science. Instead, costs, benefits, and other values properly enter both individual and collective decisions.I have writtenthreetimessince then about gradual recognition of this argument among medical professionals as well as journalists. I a...
Source: Cato-at-liberty - February 16, 2022 Category: American Health Authors: Peter Van Doren Source Type: blogs
