Ferroptosis, a novel form of non-apoptotic cell death, holds great therapeutic potential
Ferroptosis is a recently recognized form of regulated necrosis. Up until now, this form of cell death has only been thought to be a possible therapeutic approach to treat tumor cells. Yet, ferroptosis also occurs in non-transformed tissues as demonstrated by this study, thus implicating this cell death pathway in the development of a wide range of pathological conditions. More specifically, the deletion of the ferroptosis-regulating enzyme Gpx4 in a pre-clinical model results in high ferroptosis rates in kidney tubular epithelial cells causing acute renal failure. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 18, 2014 Category: Science Source Type: news
New Biomarkers to Predict Risk for Nephropathy in DiabetesNew Biomarkers to Predict Risk for Nephropathy in Diabetes
Which are the new investigational biomarkers that could help better identify diabetic patients who are likely to progress to renal failure? Medscape Diabetes & Endocrinology (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - October 28, 2014 Category: Endocrinology Tags: Diabetes & Endocrinology Commentary Source Type: news
TPR Podcast Episode #6: I’m tripping and I can’t get down
TPR Podcast Episode 6: I’ve Tripped and I Can’t Get Down
Written by Theresa Kim, MD
Outline
1) Synthetic cathinones
2) Piperazine compounds
3) Gamma-hydroxybutyric acid (GHB)
4) 25C-NBOMe
This month’s podcast was inspired by the New York Times article “A Year After Drug Deaths, the Electric Zoo Music Festival Tries Again” which covered designer drug related deaths associated with summer music festivals
Synthetic Cathinones
Derivatives of the Catha edulis (khat) plant’s psychoactive alkaloid (cathinone)
o examples: mephedrone, methedrone, MD...
Source: The Poison Review - October 7, 2014 Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast Source Type: news
Boy, 10, wins £5 million compensation after series of doctors' blunders left him needing a kidney transplant
A judge at London's High Court awarded Lucas Tuppeny compensation after a series of mistakes by doctors at the Bupa Cromwell Hospital in Kensington left him in renal failure needing a transplant. (Source: the Mail online | Health)
Source: the Mail online | Health - October 1, 2014 Category: Consumer Health News Source Type: news
Study: CardioMEMs implanted heart monitor safe for renal failure patients
New data from CardioMEMs CHAMPION clinical trial shows that the company's implanted pulmonary artery pressure monitor helps reduce heart failure hospitalizations without compromising kidney function in patients with renal failure.
St. Jude Medical (NYSE:STJ) subsidiary CardioMEMs touted new study results this week showing that its implanted heart monitor is safe and effective in patients with chronic kidney disease.
CardioMEMS Inc., St. Jude MedicalNews Well, Clinical Trials, Cardiovascular, Implants, Renalread more (Source: Mass Device)
Source: Mass Device - September 16, 2014 Category: Medical Equipment Authors: Arezu Sarvestani Source Type: news
Case series: 9 patients with acute kidney injury after smoking a synthetic cannabinoid
This article is a very complete and finely done description both of the clinical syndrome of AKI associated with use of synthetic cannabinoids, and the related public health investigation. [HT @DougBorys]
Related posts:
Four (really three) cases of acute kidney injury associated with us of synthetic cannabinoids
MMWR: synthetic pot suspect in cases of kidney failure
Blueberry “spice” in Wyoming linked to cases of renal failure (Source: The Poison Review)
Source: The Poison Review - August 22, 2014 Category: Toxicology Authors: Leon Tags: Medical acute kidney injury clown loyal renal toxicity spice synthetic cannabinoid Source Type: news
Obstetric Acute Renal Failure on the Rise, but Why? (FREE)
By Amy Orciari Herman
Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, FASAM
Obstetric acute renal failure appears to be on the rise, and while the reasons are largely unknown, peripartum treatment for preeclampsia may play … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - July 31, 2014 Category: Primary Care Source Type: news
Uganda: Kidney Disease Treatment
[Independent]Frank Sanyu is on dialysis treatment at Mulago hospital. He started undergoing this treatment in 2012 when he was first diagnosed with acute renal failure. Ever since, his greatest worry has been how he would finally raise money to go abroad for a transplant. Now, this worries him no more since Mulago is to start carrying out kidney transplant operations soon. Sanyu, 45, was put on dialysis after he visited many hospitals in his upcountry district and his swollen legs problem could not be managed though th (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - July 14, 2014 Category: African Health Source Type: news
Association between temperature and emergency room visits for cardiorespiratory diseases, metabolic syndrome-related diseases, and accidents in metropolitan taipei - Wang YC, Lin YK.
This study evaluated risks of the emergency room visits (ERV) for cerebrovascular diseases, heart diseases, ischemic heart disease, hypertensive diseases, chronic renal failure (CRF), diabetes mellitus (DM), asthma, chronic airway obstruction no... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - June 20, 2014 Category: Global & Universal Tags: Environmental Issues, Climate, Geophysics Source Type: news
Rubbing alcohol toxicity
3.5 out of 5 stars
Isopropanol poisoning. slaughter RJ et al. Clin Toxicol 2014 May 9 [Epub ahead of print]
Abstract
This comprehensive and well done review article will tell you perhaps more than you wanted to know about isopropyl alcohol poisoning.
This is, frankly, not the sexiest topic in medical toxicology, since isopropanol ingestion generally responds to supportive care and rarely causes death. However, for those who want to get granular on the subject, this is now the go-to paper.
Some key points:
Isopropanol is rapidly absorbed, mostly in the first 30 minutes after ingestion.
Isopropanol toxicity typically pres...
Source: The Poison Review - May 31, 2014 Category: Toxicology Authors: Leon Tags: Medical isopropanol isopropyl alcohol Review rubbing alcohol Source Type: news
Class I Medical Device Recall: Fresenius NaturaLyte Liquid Bicarbonate Concentrate (Part Number: 08-4000-LB) - Bacterial Contamination
NaturaLyte Liquid Bicarbonate Concentrate is used in the treatment of acute and chronic renal failure during hemodialysis. The concentrate is formulated for use with a three-stream hemodialysis machine, which is calibrated for acid and bicarbonate... (Source: Food and Drug Adminstration (FDA): CDRHNew)
Source: Food and Drug Adminstration (FDA): CDRHNew - May 28, 2014 Category: Medical Equipment Source Type: news
Self-confessed former 'bad boy' donates kidney to cystic fibrosis sufferer
Wesley Joyce decided to 'change his life' after the plight of 34-year-old Sally-Anne Grainger, from Worcestershire, who went into renal failure after having to take strong medication following a double lung transplant in 2009. (Source: the Mail online | Health)
Source: the Mail online | Health - May 22, 2014 Category: Consumer Health News Source Type: news
'I feel like I've been given four lives': Father is among first to receive THREE kidney transplants from his OWN family
Andy Knox went into renal failure when he was 25 years old. His mother, father and sister all stepped in, undergoing transplant operations at the Royal Liverpool University Hospital to help save his life. (Source: the Mail online | Health)
Source: the Mail online | Health - May 9, 2014 Category: Consumer Health News Source Type: news
Middle East respiratory syndrome coronavirus (MERS-CoV) – update
On 15 April 2014, the IHR National Focal Point of Yemen notified WHO of a laboratory confirmed case of MERS-CoV in a 44 year-old male residing in Shibam. The patient was diagnosed as having hepatitis B and is reported to have developed symptoms on 17 March 2014, including fever, productive cough, chills, headache, muscle aches, and shortness of breath. He was admitted to hospital on 22 March 2014 in Hadramoot Governorate, and subsequently transferred on 29 March 2014 to an intensive-care unit of a private hospital in Sanaa. He was intubated, developed renal failure, and died on 31 March 2014. (Source: WHO Disease Outbreaks)
Source: WHO Disease Outbreaks - May 7, 2014 Category: Infectious Diseases Tags: coronavirus [subject], Disease outbreak news [doctype], Eastern Mediterranean Region [region], Middle East respiratory syndrome coronavirus (MERS-CoV), novel coronavirus, respiratory disease [subject], yem, Yemen [country], , Coronavirus infections, Coron Source Type: news
More effective kidney stone treatment, from macroscopic to nanoscale
Researchers have hit on a novel method to help kidney stone sufferers ensure they receive the correct and most effective treatment possible. Kidney stones represent a major medical problem in the western and developing world. If left untreated, apart from being particularly painful, they can lead to renal failure and other complications. In many patients treated successfully, stone recurrence is also a major problem. Clearly a more effective pathological approach to diagnosis and treatment needs to be identified to ensure successful eradication of stones. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 17, 2014 Category: Science Source Type: news
