Self-confessed former 'bad boy' donates kidney to cystic fibrosis sufferer

Wesley Joyce decided to 'change his life' after the plight of 34-year-old Sally-Anne Grainger, from Worcestershire, who went into renal failure after having to take strong medication following a double lung transplant in 2009.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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ConclusionsEhrlichia-induced HLH is a potential serious complication with relatively high occurrence rate; patients manifest severe disease with end-organ damage requiring longer hospital stay.
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
Authors: Ceylan B, Yilmaz M, Beköz HS, Ramadan S, Ertan Akan G, Mert A Abstract Invasive aspergillosis is a severe infection that generally involves the lungs. Primary gastrointestinal aspergillosis is the least common form of invasive aspergillosis. A patient aged 65 years developed a febrile neutropenic episode following an autologous stem cell transplant for plasmacytoid variant diffuse large B-cell gastric non-Hodgkin's lymphoma. He had abdominal pain on the second day of the febrile neutropenic episode and ileus occurred on the sixth day. His general condition deteriorated despite broad spectrum antibioti...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Authors: Bejjanki H, Koratala A Abstract Rothia mucilaginosa, previously known as Stomatococcus mucilaginosus, is a Gram-positive coccus that is a part of the oropharyngeal and upper respiratory tract microbiota. Although this organism is believed to be of low virulence, it is increasingly being recognized as an opportunistic pathogen mostly affecting immunocompromised hosts. In this article, we describe a case of Rothia mucilaginosa bacteremia in an immunocompromised heart transplant recipient with end-stage renal disease, who was getting maintenance hemodialysis via a tunneled catheter. To the best of our knowled...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
IS, Bran EL Abstract Alopecia areata (AA) is a polygenic autoimmune disease. The immunosuppressant drugs taken by patients who undergo solid organ transplantation might therefore be useful in its control. The literature, however, contains conflicting information in this regard. This contribution describes seven patients with AA, all of whom had undergone solid organ transplantation and were receiving treatment with immunosuppressant drugs. Patterns were sought that might suggest whether the administration of these drugs was affecting the appearance, progress, or resolution of AA. Only seven out of 469 patients (in...
Source: Skinmed - Category: Dermatology Authors: Tags: Skinmed Source Type: research
Publication date: Available online 19 March 2019Source: American Journal of OtolaryngologyAuthor(s): Adam C. Kaufman, Steven J. EliadesAbstractAminoglycoside antibiotics have a long history of use in the control of gram-negative bacterial infections, but their systemic use has been complicated by known ototoxicity and nephrotoxicity. Because of the utility of these medications in patients with frequent pulmonary infections, there has been a move towards the use of inhaled agents, in particular tobramycin, due to a lower rate of systemic complications. Inhaled tobramycin is generally consider to be safe from otologic compli...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
An appropriate diagnostic evaluation is essential for the most appropriate treatment to be performed. Currently, macroprolactinemia is the third most frequent cause of non-physiological hyperprolactinemia after drugs and prolactinomas. Up to 40% of macroprolactinemic patients may present with hypogonadism symptoms, infertility and/or galactorrhea. Thus, the screening for macroprolactin is indicated not only for asymptomatic subjects but also for those without an obvious cause for their prolactin (PRL) elevation. Before submitting patients to macroprolactin screening and pituitary magnetic resonance imaging (MRI), one shoul...
Source: Neuroendocrinology - Category: Endocrinology Source Type: research
Tumor development may be suppressed by the immune system via elimination of cancer cells or via prevention of cancer cell outgrowth. The existence of CD8+CD69+CD103+ tissue resident memory T cells (TRM) and their known role in immune surveillance led Park and colleagues to investigate whether this cell population mediated immunity to epidermis-derived melanoma. Using a mouse model of transplantable melanoma, these investigators demonstrated that tissue-resident TRM established a dynamic melanoma-immune equilibrium in the epidermis, suppressing macroscopic tumor development.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editorial Source Type: research
Authors: Deng F, Zhang J, Li Y, Wang W, Hong D, Li G, Feng J Abstract Immunoglobulin A nephropathy (IgAN) is characterized by mesangial IgA and IgG co-deposition. As the clinical course of IgAN is highly variable, a lot of patients will eventually develop to end-stage renal disease (ESRD) within years. Hirudin, a potent and specific thrombin inhibitor, has been reported to treat IgAN with hematuria, but the mechanism is unclear. Our study aims to explore the potential of hirudin and the underlying mechanism in the treatment of IgAN. The establishment of IgAN model was set up in rats through oral and intravenous imm...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Go online to PeerView.com/WPW860 to view the entire program with slides. In this activity, an expert in multiple myeloma discusses newer safety and efficacy data surrounding novel and emerging therapeutic drug classes for multiple myeloma, including agents directed against intracellular targets and immune-based treatment. The activity will also include expert insights on how to develop effective, individualized treatment strategies with novel components that are informed by clinical findings and how to manage treatment-related adverse effects associated with emerging agent classes. Upon completion of this activity, partici...
Source: PeerView CME/CE Audio Podcast - Immunology - Category: Allergy & Immunology Authors: Tags: Science, Medicine Source Type: podcasts
Authors: Kalisvaart M, Perera MTPR PMID: 30884985 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
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