27 fatalities from laboratory-confirmed exposure to PMMA (“Dr. Death”)
4 out of 5 stars
Deaths from exposure to paramethoxymethamphetamine in Alberta and British Columbia, Canada: a case series. Nicol JJE et al. CMAJ Open. 2015 Jan 13;3(1):E83-9
Full Text
From June 2011 through April 2012, 27 deaths in the Canadian provinces of Albert and British Columbia were attributed to the hallucinogenic stimulant para-methoxy-N-methylamphetamine (PMMA) as the primary toxic agent based postmortem examination and toxicology results. PMMA is so dangerous that it is known on the street as “Death” and “Dr. Death.” This paper constitutes a retrospective review of those cases based on r...
Source: The Poison Review - April 18, 2015 Category: Toxicology Authors: Leon Tags: Best of TPR Medical alberta bath salt british columbia canada death dr. death ecstasy fatality hyperthermia mdma PMMA serotonin syndrome synthetic designer drug Source Type: news
How Long Do Creatine Kinase Levels Remain Elevated After Exercise?
Discussion
Acute rhabdomyolysis is an emergency that can cause acute renal failure (especially acute tubular necrosis caused by myoglobinemia) and electrolyte abnormalities. Common presenting findings are dark urine, myalgia and muscle weakness. Milder episodes can go unnoticed. Acute exertional rhabdomyolysis or unrecognized muscle injury can occur in underconditioned persons and even trained athletes who increase their exertion or exercise. Being unaccustomed to the ambient conditions such as heat, humidity and sun can also increase fluid loss and the risk of muscle injury. An overview and differential diagnosis of rhab...
Source: PediatricEducation.org - April 13, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Gross Anatomy: Tea Time in the ED
(MedPage Today) -- Is iced black tea an unknown culprit in renal failure? (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - April 1, 2015 Category: Urology & Nephrology Source Type: news
Gross Anatomy: Tea Time in the ED
(MedPage Today) -- Is iced black tea an unknown culprit in renal failure? (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - April 1, 2015 Category: Geriatrics Source Type: news
What Is Causing This Acute Renal Failure?What Is Causing This Acute Renal Failure?
What could be the reason for this sudden onset of renal insufficiency? Medscape Internal Medicine (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - March 16, 2015 Category: Internal Medicine Tags: Internal Medicine Case Challenge Source Type: news
New cellular pathway defect found in cystinosis
Scientists have identified a new cellular pathway affected in cystinosis, a rare genetic disorder that can result in eye and kidney damage. The findings could eventually lead to new drug treatments for reducing or preventing the onset of renal failure in patients. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 10, 2015 Category: Science Source Type: news
Renal involvement in mushroom poisoning: the case of Orellanus syndrome - Esposito P, La Porta E, Calatroni M, Bianzina S, Libetta C, Gregorini M, Rampino T, Dal Canton A.
Although mushroom poisoning is a rare cause of acute renal injury, in some cases it may lead to the development of a severe and irreversible renal failure. Orellanus syndrome is the most important example of organic renal damage related to mushroom consump... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - February 7, 2015 Category: Global & Universal Tags: Poisoning Source Type: news
New Study Finds That Robotically Assisted Surgery For Kidney Cancer Increases Access To Partial Versus Radical Nephrectomy, Reducing Mortality, Renal Failure And Long-Term Costs
A new study, published in the February issue of Health Affairs, found that in terms of quality-adjusted life-years gained, the benefits of robotic-assisted partial nephrectomy surgery for kidney cancer patients outweighed the health care and surgical costs to patients and payers by a ratio of five to one. (Source: Medical Design Online News)
Source: Medical Design Online News - February 6, 2015 Category: Medical Equipment Source Type: news
First successful organ donation from newborn carried out in UK
The very first successful organ donation from a newborn carried out in the UK is has been reported. The donation involved the kidneys, which were transplanted into a patient with renal failure, and liver cells (hepatocytes), which were transfused into a further recipient. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 20, 2015 Category: Science Source Type: news
Saxagliptin: A Therapy Option in Diabetes and Renal Failure Saxagliptin: A Therapy Option in Diabetes and Renal Failure
The largest-ever trial to examine use of a diabetes medicine in patients with renal failure has published its findings. Other megatrials in this population, which is challenging to treat, are ongoing. Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - January 13, 2015 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
Hallucinogenic stimulant PMMA found in “Superman” pills that killed 4 in Britain
The Guardian (U.K.) reported yesterday that the deaths of 4 men in Britain over the holidays were associated with a drug — purported to be MDMA (ecstasy) — that actually contained the hallucinogenic stimulant PMMA, a far more dangerous drug. The deaths all seemed to be related to a 5-sided pill that reproduced the famous Superman logo.
PMMA is related to PMA, a drug so lethal it has been marketed under the name “Dr. Death.” Some data indicates that PMMA (para-methoxymethamphetamine) is metabolized to PMA (para-methamphetamine.) Both PMA and PMMA cause increased release of serotonin along with decreased re...
Source: The Poison Review - January 8, 2015 Category: Toxicology Authors: Leon Tags: Medical dr. death ecstasy mdma paramethoxyamphetamine paramethoxymethamphetamine pma PMMA serotonin syndrome superman Source Type: news
Death after injecting alpha-PVP
3 out of 5 stars
Death due to intravenous use of α-pyrrolidinopentiophenone. Sellors K et al. Med J Aust 2014 Nov 17;201:601-3.
Full Text
α-pyrrolidinopentiophenone (α-PVP) is a synthetic cathinone stimulant with structural similarities to MDPV. Like MDPV, α-PVP contains a pyrrolidine ring, a 5-sided nitrogen-containing component that enables the molecule to effectively block reuptake of dopamine and norepinephrine, with much weaker effects at the serotonin transporter.
This dramatic case report describes a 44-year-old man who injected a product labelled “Smokin’ Slurries Scrubba” (α-PVP) intrave...
Source: The Poison Review - December 31, 2014 Category: Toxicology Authors: Leon Tags: Medical agitted delirium alphya-PVP death fatality MDPV Source Type: news
Acute renal failure following multiple wasp stings - Butt G, Ullah K, Kanwal K, Mudassir.
We report two such cases. The first case was a 14 years old boy admitted with oliguria following multiple wasp stings. He had grossly deranged renal function requiring hemodialysis support. The... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - December 20, 2014 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Palytoxin: deadlier than fugu?
Palytoxin
3 out of 5 stars
Hyperkalemia, Hyperphosphatemia, Acute Kidney Injury, and Fatal Dysrhythmias After Consumption of Palytoxin-Contaminated Goldspot Herring. Wu M: et al. Ann Emerg Med 2014 Dec;64:633-6.
Abstract
Palytoxin, a huge heat-stable molecule, is one of the most deadly of all the marine toxins. Fortunately, cases of severe palytoxin poisoning are relatively rare. This paper from Taiwan describes 4 patients from a single family who became symptomatic after eating fish soup made from the local catch. One person died. The presence of palytoxin was confirmed in samples of leftover fish.
The following question...
Source: The Poison Review - December 5, 2014 Category: Toxicology Authors: Leon Tags: Medical fish poisoning Goldspot herring marine palytoxin Source Type: news
NICE sets out standards for treating patients with renal failure
A new quality standard that sets out how best to care for adults who need treatment for chronic kidney disease has been published by the National Institute for Health and Care Excellence. (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - November 28, 2014 Category: Nursing Source Type: news
