Structural features of Novel 2,6-diarylpiperidin-4-ones derived from the methyl ether of raspberry ketone: Investigation through spectral, single crystal and DFT studies
Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): D. Shanthi, K. Rajeswari, C. Udhaya Kumar, T. Vidhyasagar, M. Velayutham PillaiAbstractRaspberry ketone has been reported to be an effective antioxidant available naturally. An attempt to incorporate the structural component of the raspberry ketone into the piperidine moiety has been achieved through Mannich condensation. The structural perspectives of the β-aminoketones synthesized were interpreted by the characterization techniques viz. FT-IR, 1D and 2D NMR techniques. The stereochemical aspects of the heterocycles are enunci...
Source: Journal of Molecular Structure - August 16, 2019 Category: Molecular Biology Source Type: research
Metabolism of Odorant Molecules in Human Nasal/Oral Cavity Affects the Odorant Perception.
In this study, we examined the mode of metabolism of food odorant molecules in the human nasal/oral cavity in vitro and in vivo. We selected 4 odorants, 2-furfurylthiol (2-FT), hexanal, benzyl acetate, and methyl raspberry ketone, which are potentially important for designing food flavors. In vitro metabolic assays of odorants with saliva/nasal mucus analyzed by gas chromatography mass spectrometry revealed that human saliva and nasal mucus exhibit the following 3 enzymatic activities: (i) methylation of 2-FT into furfuryl methylsulfide (FMS); (ii) reduction of hexanal into hexanol; and (iii) hydrolysis of benzyl acetate i...
Source: Chemical Senses - June 28, 2019 Category: Biochemistry Authors: Ijichi C, Wakabayashi H, Sugiyama S, Ihara Y, Nogi Y, Nagashima A, Ihara S, Niimura Y, Shimizu Y, Kondo K, Touhara K Tags: Chem Senses Source Type: research
Construction of synthetic pathways for raspberry ketone production in engineered Escherichia coli.
Abstract
Raspberry ketone is an important ingredient in the flavor and fragrance industries. Due to its low content in fruits and vegetables, the production of natural raspberry ketone using heterologous synthesis in microbial strains is recently attracting increased attention. In this work, a heterologous pathway to produce raspberry ketone from p-coumaric acid, including 4-coumarate: CoA ligase (4CL), benzalacetone synthase (BAS), and raspberry ketone/zingerone synthase (RZS1) from plants, was successfully assembled in Escherichia coli. When the RZS1 gene was introduced into E. coli and co-expressed with...
Source: Applied Microbiology and Biotechnology - March 25, 2019 Category: Microbiology Authors: Wang C, Zheng P, Chen P Tags: Appl Microbiol Biotechnol Source Type: research
Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet
ConclusionOur study highlights the involvement ofp-IRS-1/p-Akt/GLUT-4, leptin/STAT-3 and SREBP-1c signaling trajectories in the beneficial combination of GC and RK, besides, the efficient rebalance of the redox status, insulin resistance and tissue fat deposition confirmed histopathologically.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 7, 2018 Category: Drugs & Pharmacology Source Type: research
Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet.
CONCLUSION: Our study highlights the involvement ofp-IRS-1/p-Akt/GLUT-4, leptin/STAT-3 and SREBP-1c signaling trajectories in the beneficial combination of GC and RK, besides, the efficient rebalance of the redox status, insulin resistance and tissue fat deposition confirmed histopathologically.
PMID: 30530230 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 6, 2018 Category: Drugs & Pharmacology Authors: Attia RT, Abdel-Mottaleb Y, Abdallah DM, El-Abhar HS, El-Maraghy NN Tags: Biomed Pharmacother Source Type: research
Floral synomone diversification of Bulbophyllum sibling species (Orchidaceae) in attracting fruit fly pollinators
We examined the semiochemical diversity in the interactions between “fruit fly orchids” and their pollinator fruit fly species in two genera, Bactrocera and Zeugodacus (Tephritidae: Diptera). Two known attractants for the Dacini fruit flies, methyl eugenol (ME) and raspberry ketone (RK), have been identified from the Bulbophyllum orchids. Additionally, zingerone (ZN), with a hybrid chemical structure between ME and RK, and attracts both ME- and RK-sensitive fly species, was also identified. Male flies utilize the floral scent as sex pheromone precursor or components to attract conspecific females and gain mating advant...
Source: Biochemical Systematics and Ecology - October 12, 2018 Category: Biochemistry Source Type: research
A highly sensitive ultra-high performance liquid chromatography/tandem mass spectrometry method with in-source fragmentation for rapid quantification of raspberry ketone
Publication date: Available online 14 August 2018Source: Journal of Food and Drug AnalysisAuthor(s): Bo Yuan, Danyue Zhao, Ruoyuan Du, Dushyant Kshatriya, Nicholas T. Bello, James E. Simon, Qingli WuAbstractRaspberry ketone (RK) is the characteristic aromatic compound in raspberry (Rubus idaeus L.) with wide applications as food additive and anti-obesity agent. However, quantification of RK has presented difficulties in MS detection and reliable LC-MS method for RK analysis in literature is in limit to date. In order to facilitate quality control of raspberry derived products and RK metabolomics study, this study aimed to ...
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research
An optimized dose of raspberry ketones controls hyperlipidemia and insulin resistance in male obese rats: effect on adipose tissue expression of adipocytokines and Aquaporin 7.
Abstract
Obesity constitutes a major worldwide problem in which hyperlipidemia and insulin resistance represents adverse metabolic consequences of it. The present study was conducted to elucidate the role of raspberry ketones (RKs) in controlling body weight gain, hyperlipidemia and insulin resistance in male obese rats through affecting the expression of various adipocytokines. As Aquaporin-7 is co-related with the expression of various adipocytokines and has recently emerged as a modulator of adipocyte metabolism, the present study evaluated the effect of RKs on adipose tissue expression of aquaporin-7(A...
Source: European Journal of Pharmacology - May 19, 2018 Category: Drugs & Pharmacology Authors: Mehanna ET, Barakat BM, ElSayed MH, Tawfik MK Tags: Eur J Pharmacol Source Type: research
Inhibitory effect of raspberry ketone on α-glucosidase: Docking simulation integrating inhibition kinetics.
Abstract
Inhibition of α-glucosidase is directly associated with treatment of type 2 diabetes. In this regard, we conducted enzyme kinetics integrated with computational docking simulation to assess the inhibitory effect of raspberry ketone (RK) on α-glucosidase. RK bound to the active site of α-glucosidase and interacted with several key residues such as ASP68, TYR71, HIS111, PHE157, PHE158, PHE177, GLN181, ASP214, THR215, ASP349, ASP408, and ARG439, as detected by protein-ligand docking simulation. Subsequently, we confirmed the action of RK on α-glucosidase as the non-competitive type of inhibition ...
Source: International Journal of Biological Macromolecules - February 22, 2018 Category: Biochemistry Authors: Xiong SL, Yue LM, Lim GT, Yang JM, Lee J, Park YD Tags: Int J Biol Macromol Source Type: research
Evaluation of Natural Product Compositions for Appetite Suppression.
Authors: Yimam M, Jiao P, Hong M, Brownell L, Lee YC, Hyun EJ, Kim HJ, Kim TW, Nam JB, Kim MR, Jia Q
Abstract
A change in homeostasis between food intake and energy expenditure is the hallmark of obesity. Many plant-based weight-management products are available in dietary supplement markets with no direct efficacy comparison. In this in vivo acute feed intake study in rats, the appetite suppression efficacy of well-known natural ingredients in the weight-loss market were evaluated. We tested pure caffeine, potato skin extract, Cissus quadrangularis extract, Garcinia cambogia extract, Crocus sativus extrac...
Source: Journal of Dietary Supplements - February 15, 2018 Category: Nutrition Tags: J Diet Suppl Source Type: research
Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats
Publication date: 1 February 2018 Source:Life Sciences, Volume 194 Author(s): Vasim Khan, Sumit Sharma, Uma Bhandari, Syed Mansoor Ali, Syed Ehtaishamul Haque Aim The cardioprotective role of raspberry ketone (RK) against isoproterenol (ISO)-induced myocardial infarction (MI) in rats was assessed. Materials and methods Rats were randomly divided into Group I - Vehicle control; Group II - Toxic control ISO (85mg/kg, s.c.); Group III, IV and V - RK (50, 100 and 200mg/kg, respectively) with ISO; Group VI- RK (200mg/kg) alone; Group VII - Propranolol (10mg/kg) with ISO; and Group VIII - Propranolol (10mg/kg) alone. Aft...
Source: Life Sciences - January 5, 2018 Category: Biology Source Type: research
Raspberry Ketone Reduced Lipid Accumulation in 3T3-L1
Cells and Ovariectomy-Induced Obesity in Wistar Rats by Regulating
Autophagy Mechanisms
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.7b03831 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - December 11, 2017 Category: Food Science Authors: Sy-Ying Leu, Yi-Chen Chen, Yung-Chieh Tsai, Yao-Wen Hung, Chih-Hsiung Hsu, Yen-Mei Lee and Pao-Yun Cheng Source Type: research
Solubility and solution thermodynamics of Raspberry Ketone in pure organic solvents and binary solvent mixtures from T=(293.15 to 333.15) K
In this study, the solubility of Raspberry Ketone in nine mono-solvents, including ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetic acid, methyl acetate, ethyl acetate, acetone, and binary mixtures of ethanol+acetone (the mass fraction of ethanol varied from 0.1 to 0.9, in intervals of 0.1) was measured at (293.15 to 333.15) K in atmospheric pressure by shake-flask method. The solubility of Raspberry Ketone both in mono- solvents and mixtures increased as the temperature increased. The deliquescent rules can be acquired by using modified Apelblat equation, van't Hoff equation, λh equation, Wilson model, Non-R...
Source: Journal of Molecular Liquids - September 28, 2017 Category: Molecular Biology Source Type: research
Heme oxygenase-1 mediates anti-adipogenesis effect of raspberry ketone in 3T3-L1 cells
Conclusion : RK may exert anti-adipogenic effects through modulation of the HO-1/Wnt/beta-catenin signaling pathway. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 22, 2017 Category: Drugs & Pharmacology Source Type: research
Synthetic biology stretching the realms of possibility in wine yeast research.
This article explores how this breakthrough and the imminent outcome of the international Yeast 2.0 (or Sc2.0) project, aimed at the synthesis of the entire genome of a laboratory strain of S. cerevisiae, might accelerate the design of improved wine yeasts.
PMID: 28458189 [PubMed - as supplied by publisher] (Source: International Journal of Food Microbiology)
Source: International Journal of Food Microbiology - April 20, 2017 Category: Food Science Authors: Jagtap UB, Jadhav JP, Bapat VA, Pretorius IS Tags: Int J Food Microbiol Source Type: research
