Raspberry ketone ameliorates nonalcoholic fatty liver disease in rats by activating the AMPK pathway
Eur J Pharmacol. 2023 Aug 18:176001. doi: 10.1016/j.ejphar.2023.176001. Online ahead of print.ABSTRACTThe current study aimed to investigate the effect of orally administered raspberry ketone (RK) on ameliorating nonalcoholic fatty liver disease (NAFLD) induced in rats by high-fat high-fructose diet (HFFD) in comparison to calorie restriction (CR) regimen. Thirty male Wistar rats were divided into two experimental groups; one was fed normal chow diet (NCD, n = 6) for 15 weeks to serve as normal control group and the other group was fed HFFD (n = 24) for 7 weeks to induce NAFLD. After induction, rats in the HFFD group were ...
Source: European Journal of Pharmacology - August 20, 2023 Category: Drugs & Pharmacology Authors: Mervat E Askar Sousou I Ali Nahla N Younis Mohamed A Shaheen Mahmoud E Zaher Source Type: research
Raspberry ketone ameliorates nonalcoholic fatty liver disease in rats by activating the AMPK pathway
Eur J Pharmacol. 2023 Aug 18:176001. doi: 10.1016/j.ejphar.2023.176001. Online ahead of print.ABSTRACTThe current study aimed to investigate the effect of orally administered raspberry ketone (RK) on ameliorating nonalcoholic fatty liver disease (NAFLD) induced in rats by high-fat high-fructose diet (HFFD) in comparison to calorie restriction (CR) regimen. Thirty male Wistar rats were divided into two experimental groups; one was fed normal chow diet (NCD, n = 6) for 15 weeks to serve as normal control group and the other group was fed HFFD (n = 24) for 7 weeks to induce NAFLD. After induction, rats in the HFFD group were ...
Source: European Journal of Pharmacology - August 20, 2023 Category: Drugs & Pharmacology Authors: Mervat E Askar Sousou I Ali Nahla N Younis Mohamed A Shaheen Mahmoud E Zaher Source Type: research
Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway
CONCLUSIONS: RKG showed remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo. Furthermore, RKG could inhibit melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes.PMID:37203852 | DOI:10.26355/eurrev_202305_32336 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 19, 2023 Category: Drugs & Pharmacology Authors: Q-Q Guo Y-Y Yuan T-W Sun S-J Wu X-H Li H-S Zhao Source Type: research
Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway
CONCLUSIONS: RKG showed remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo. Furthermore, RKG could inhibit melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes.PMID:37203852 | DOI:10.26355/eurrev_202305_32336 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 19, 2023 Category: Drugs & Pharmacology Authors: Q-Q Guo Y-Y Yuan T-W Sun S-J Wu X-H Li H-S Zhao Source Type: research
Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway
CONCLUSIONS: RKG showed remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo. Furthermore, RKG could inhibit melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes.PMID:37203852 | DOI:10.26355/eurrev_202305_32336 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 19, 2023 Category: Drugs & Pharmacology Authors: Q-Q Guo Y-Y Yuan T-W Sun S-J Wu X-H Li H-S Zhao Source Type: research
Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway
CONCLUSIONS: RKG showed remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo. Furthermore, RKG could inhibit melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes.PMID:37203852 | DOI:10.26355/eurrev_202305_32336 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 19, 2023 Category: Drugs & Pharmacology Authors: Q-Q Guo Y-Y Yuan T-W Sun S-J Wu X-H Li H-S Zhao Source Type: research
Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway
CONCLUSIONS: RKG showed remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo. Furthermore, RKG could inhibit melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes.PMID:37203852 | DOI:10.26355/eurrev_202305_32336 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 19, 2023 Category: Drugs & Pharmacology Authors: Q-Q Guo Y-Y Yuan T-W Sun S-J Wu X-H Li H-S Zhao Source Type: research
Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway
CONCLUSIONS: RKG showed remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo. Furthermore, RKG could inhibit melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes.PMID:37203852 | DOI:10.26355/eurrev_202305_32336 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 19, 2023 Category: Drugs & Pharmacology Authors: Q-Q Guo Y-Y Yuan T-W Sun S-J Wu X-H Li H-S Zhao Source Type: research
Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway
CONCLUSIONS: RKG showed remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo. Furthermore, RKG could inhibit melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes.PMID:37203852 | DOI:10.26355/eurrev_202305_32336 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 19, 2023 Category: Drugs & Pharmacology Authors: Q-Q Guo Y-Y Yuan T-W Sun S-J Wu X-H Li H-S Zhao Source Type: research
Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway
CONCLUSIONS: RKG showed remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo. Furthermore, RKG could inhibit melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes.PMID:37203852 | DOI:10.26355/eurrev_202305_32336 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 19, 2023 Category: Drugs & Pharmacology Authors: Q-Q Guo Y-Y Yuan T-W Sun S-J Wu X-H Li H-S Zhao Source Type: research
