Dexmedetomidine Pretreatment Confers Myocardial Protection and Reduces Mechanical Ventilation Duration for Patients Undergoing Cardiac Valve Replacement under Cardiopulmonary Bypass
CONCLUSION: The study suggests that 0.50 µg/kg Dex pretreatment could reduce propofol use and the duration of mechanical ventilation, and confer myocardial protection without increased adverse events during cardiac valve replacement.PMID:38684422 | DOI:10.5761/atcs.oa.23-00210 (Source: Annals of Thoracic and Cardiovascular Surgery)
Source: Annals of Thoracic and Cardiovascular Surgery - April 29, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Binglin Yuan Xiqiang Huang Junlin Wen Mengzhe Peng Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
Perioperative management and outcomes for posterior spinal fusion in patients with Friedreich ataxia: A single-center, retrospective study
CONCLUSIONS: Patients with Friedreich ataxia are at high risk for perioperative complications when undergoing posterior spinal fusion and coordinated multidisciplinary care is required at each stage. Future research should focus on the utility of intraoperative echocardiography, optimal anesthetic agent selection, and targeted fluid management to reduce postoperative cardiac complications.PMID:38655751 | DOI:10.1111/pan.14896 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 24, 2024 Category: Anesthesiology Authors: Elizabeth M O'Brien Natalie Neiswinter Kimberly Y Lin David Lynch Keith Baldwin Victoria Profeta John M Flynn Wallis T Muhly Source Type: research
Perioperative management and outcomes for posterior spinal fusion in patients with Friedreich ataxia: A single-center, retrospective study
CONCLUSIONS: Patients with Friedreich ataxia are at high risk for perioperative complications when undergoing posterior spinal fusion and coordinated multidisciplinary care is required at each stage. Future research should focus on the utility of intraoperative echocardiography, optimal anesthetic agent selection, and targeted fluid management to reduce postoperative cardiac complications.PMID:38655751 | DOI:10.1111/pan.14896 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 24, 2024 Category: Anesthesiology Authors: Elizabeth M O'Brien Natalie Neiswinter Kimberly Y Lin David Lynch Keith Baldwin Victoria Profeta John M Flynn Wallis T Muhly Source Type: research
Incidence of dreaming during ciprofol anesthesia for painless gastroscopy
CONCLUSIONS: The postoperative dream recall incidence in this study was 27.5% among patients undergoing painless gastroscopy under ciprofol sedation anesthesia.PMID:38652450 | DOI:10.23736/S0375-9393.24.17845-5 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - April 23, 2024 Category: Anesthesiology Authors: Xinyu Cao Jiejie Zhou Miaomiao Xu Bin Wang Chongya Yang Jingwei Xiong Kangli Hui Source Type: research
Effect of converting from propofol to remimazolam with flumazenil reversal on recovery from anesthesia in outpatients with mental disabilities: a randomized controlled trial
General anesthesia is often necessary for dental treatment of outpatients with mental disabilities. Rapid recovery and effective management of postoperative nausea and vomiting (PONV) are critical for outpatie... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - April 22, 2024 Category: Anesthesiology Authors: Sooyoung Jeon, Jieun Kim, Myong-Hwan Karm and Jin-Tae Kim Tags: Research Source Type: research
Construction of preclinical evidence for propofol in the treatment of reperfusion injury after acute myocardial infarction: A systematic review and meta-analysis
This study presents a comprehensive analysis of 48 relevant animal studies investigating propofol's preventive effects on MIRI. Propofol administration demonstrated a reduction in myocardial IS and decreased levels of myocardial injury biomarkers (CK-MB, LDH, cTnI). Moreover, propofol improved myocardial function parameters (+dp/dtmax, -dP/dtmax, LVEF, LVFS), exhibited favorable effects on inflammatory markers (IL-6, TNF-α) and oxidative stress markers (SOD, MDA), and reduced myocardial cell apoptotic index (AI). These findings suggest propofol exerts cardioprotective effects by reducing myocardial injury, decreasing infa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 19, 2024 Category: Drugs & Pharmacology Authors: Tao Li Yanwei Li Yiwei Zeng Xin Zhou Su Zhang Yulan Ren Source Type: research
Differential Susceptibility to Propofol and Ketamine in Primary Cultures of Young and Senesced Astrocytes
In this study, we examined the survival and viability of both young and senescent astrocytes in culture after adding propofol and ketamine to the media at varying strengths. Oxidative stimulus was applied to commercially available fetal cell lines of human astrocytes in vitro to induce morphological changes in cellular senescence. Our results indicate that propofol reduces the survival of young astrocytes as compared to controls, as well as to ketamine. These effects were seen in comparisons of total cell count and at both high and low dose concentrations. High doses of propofol also significantly reduced cell viability co...
Source: Anesthesiology Research and Practice - April 18, 2024 Category: Anesthesiology Authors: Liang Huang Ferit Tuzer Abigail Murtha Michael Green Claudio Torres Henry Liu Shadi Malaeb Source Type: research
