Propofol Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Restrictive use of Restraints and Delirium Duration in the Intensive Care Unit (R2D2-ICU): protocol for a French multicentre parallel-group open-label randomised controlled trial
Introduction Physical restraint (PR) is prescribed in patients receiving invasive mechanical ventilation in the intensive care unit (ICU) to avoid unplanned removal of medical devices. However, it is associated with an increased risk of delirium. We hypothesise that a restrictive use of PR, as compared with a systematic use, could reduce the duration of delirium in ICU patients receiving invasive mechanical ventilation. Methods and analysis The Restrictive use of Restraints and Delirium Duration in ICU (R2D2-ICU) study is a national multicentric, parallel-group, randomised (1:1) open-label, controlled, superiority trial, ...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Sonneville, R., Couffignal, C., Sigaud, F., Godard, V., Audibert, J., Contou, D., Celier, A., Djibre, M., Schmidt, J., Jaquet, P., Mekontso Dessap, A., Bourel, C., Bellot, R., Roy, C., Lamara, F., Essardy, F., Timsit, J.-F., Cornic, R., Bouadma, L., On be Tags: Open access, Intensive care Source Type: research

Apnea during moderate to deep sedation using continuous infusion of remimazolam compared to propofol and dexmedetomidine: A retrospective observational study
by Chahyun Oh, Jiyong Lee, Jieun Lee, Yumin Jo, Sanghun Kwon, Minhae Bang, Chaeseong Lim, Yoon-Hee Kim, Sun Yeul Lee, Boohwi Hong Remimazolam’s rapid onset and offset make it an innovative sedative for use during regional anesthesia. However, its respiratory safety profile is not well understood. We compared the continuous infusion of remimazolam with commonly used sedatives, propofol and dexmedetomidine, after regional an esthesia. In this retrospective study, the incidence of apnea (>10 seconds) was assessed in patients who underwent orthopedic surgery under regional anesthesia and received moderate to deep sedation u...
Source: PLoS One - April 17, 2024 Category: Biomedical Science Authors: Chahyun Oh Source Type: research

Application of propofol-remifentanil intravenous general anesthesia combined with regional block in pediatric ophthalmic surgery
The aim of this study is to observe the anesthetic effect and safety of intravenous anesthesia without muscle relaxant with propofol-remifentanil combined with regional block under laryngeal mask airway in ped... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - April 17, 2024 Category: Anesthesiology Authors: Ming-Ying Li, Yu-Da Fei, Xiao-Xia Zhang, Tian-Wen Chen, Jie Li, Xiao-Li Sun and Zhen-Yuan Wang Tags: Research Source Type: research

Decoding the Neurotoxic Effects of Propofol: Insights into the RAR α-Snhg1-Bdnf Regulatory Cascade
Am J Physiol Cell Physiol. 2024 Apr 15. doi: 10.1152/ajpcell.00547.2023. Online ahead of print.ABSTRACTThe potential neurotoxic effects of propofol, an extensively utilized anesthetic, underline the urgency to comprehend its influence on neuronal health. Insights into the role of the RARα-Snhg1-Bdnf network can offer significant advancements in minimizing these effects. The study targets the exploration of the RARα and Snhg1 regulatory network's influence on Bdnf expression in the realm of propofol-induced neurotoxicity. Harnessing the GEO database and utilizing JASPAR and RPISeq for projections, the study embarks on an ...
Source: American Journal of Physiology. Cell Physiology - April 15, 2024 Category: Cytology Authors: Yuhai Xu Xin Xin Tianzhu Tao Source Type: research

Decoding the Neurotoxic Effects of Propofol: Insights into the RAR α-Snhg1-Bdnf Regulatory Cascade
Am J Physiol Cell Physiol. 2024 Apr 15. doi: 10.1152/ajpcell.00547.2023. Online ahead of print.ABSTRACTThe potential neurotoxic effects of propofol, an extensively utilized anesthetic, underline the urgency to comprehend its influence on neuronal health. Insights into the role of the RARα-Snhg1-Bdnf network can offer significant advancements in minimizing these effects. The study targets the exploration of the RARα and Snhg1 regulatory network's influence on Bdnf expression in the realm of propofol-induced neurotoxicity. Harnessing the GEO database and utilizing JASPAR and RPISeq for projections, the study embarks on an ...
Source: Am J Physiol Cell Ph... - April 15, 2024 Category: Cytology Authors: Yuhai Xu Xin Xin Tianzhu Tao Source Type: research

Retraction Note: Propofol suppresses growth, migration and invasion of A549 cells by down-regulation of miR-372
(Source: BMC Cancer)
Source: BMC Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Hai Sun and Dengyu Gao Tags: Retraction Note Source Type: research

Development of a predictive model for hypoxia due to sedatives in gastrointestinal endoscopy: a prospective clinical study in Korea
CONCLUSIONS: High BMI, neck circumference, and Mallampati score were independently associated with hypoxia during sedative endoscopy. We constructed a model with acceptable performance for predicting hypoxia during sedative endoscopy.PMID:38605689 | DOI:10.5946/ce.2023.198 (Source: Clinical Endoscopy)
Source: Clinical Endoscopy - April 12, 2024 Category: Gastroenterology Authors: Jung Wan Choe Jong Jin Hyun Seong-Jin Son Seung-Hak Lee Source Type: research