Propofol modulates Nrf2/NLRP3 signaling to ameliorate cigarette smoke-induced damage in human bronchial epithelial cells
This study aimed to elucidate the protective mechanisms of propofol against CSE-induced damage in human bronchial epithelial 16HBE cells. In CSE-induced 16HBE cells treated by propofol with or without transfection of nuclear factor erythroid 2-related factor 2 (Nrf2) interference plasmids, CCK-8 assay and lactate dehydrogenase (LDH) assay evaluated cytotoxicity. TUNEL assay and Western blot appraised cell apoptosis. ELISA and relevant assay kits severally measured inflammatory and oxidative stress levels. DCFH-DA fluorescent probe detected intracellular reactive oxygen species (ROS) activity. Immunofluorescence staining an...
Source: Tissue and Cell - March 13, 2024 Category: Cytology Authors: Linmei Xu Yanbin Wang Qumin Chen Xiaolei Zhu Jiageng Hong Source Type: research
Adverse Drug Events Observed with the Newly Approved Remimazolam in Comparison to Propofol for General Anesthesia in Patients Undergoing Surgery: A Meta-analysis
ConclusionOur current analysis showed that the newly approved remimazolam was apparently associated with significantly fewer adverse drug events in comparison to propofol for GA in patients undergoing surgery. Therefore, this new drug should be further studied and more research with larger population sizes should be carried out to confirm this hypothesis. (Source: Advances in Therapy)
Source: Advances in Therapy - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Altitude effect on Propofol Pharmacokinetics in Rats
CONCLUSION: The pharmacokinetic characteristics of Propofol are significantly altered in high-altitude hypoxic environments.PMID:38468514 | DOI:10.2174/0113892002285571240220131547 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 12, 2024 Category: Drugs & Pharmacology Authors: Lijun Li Xuejun Wang Sheng Wang Li Wen Haopeng Zhang Source Type: research
Altitude effect on Propofol Pharmacokinetics in Rats
CONCLUSION: The pharmacokinetic characteristics of Propofol are significantly altered in high-altitude hypoxic environments.PMID:38468514 | DOI:10.2174/0113892002285571240220131547 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 12, 2024 Category: Drugs & Pharmacology Authors: Lijun Li Xuejun Wang Sheng Wang Li Wen Haopeng Zhang Source Type: research
Efficacy and safety of esketamine combined with propofol for curative endoscopic resection in colorectum: a prospective, randomized controlled trial
Curative endoscopic resection is widely used to treat colonic polyps and early stage cancers. The anesthetic strategy commonly involves the use of propofol combined with a small dose of opioids for sedation. A... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - March 9, 2024 Category: Anesthesiology Authors: Yimei Ma, Jiali Wang, Yuying Yang and Minmin Yao Tags: Research Source Type: research
