How safe is COVID-19 vaccination among pregnant women and its outcome - A hospital-based retrospective study in Indian population
CONCLUSION: AEFI among pregnant women were found less compared to the general population. The study also revealed that both Covishield and Covaxin are found safe for pregnancy outcomes and can be given to pregnant women during any trimester of pregnancy message for a family physician.PMID:38024942 | PMC:PMC10657075 | DOI:10.4103/jfmpc.jfmpc_333_23 (Source: Primary Care)
Source: Primary Care - November 29, 2023 Category: Primary Care Authors: Niraj B Pandit Purvi R Fulmali Piyusha Chandrayan Kishor Chauhan Dipika L Bhil Manish N Rasania Source Type: research
Reducing the Rate of Premature Births through Early Diagnosis and Pregnancy-Adapted Treatment of Hypothyroidism
CONCLUSION: The results show an association between more intensive thyroid diagnostics and pregnancy-adapted L-thyroxine replacement therapy and a decrease in premature births. Further studies should be conducted to confirm these results.PMID:38024217 | PMC:PMC10631574 | DOI:10.1055/a-2103-8143 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - November 29, 2023 Category: OBGYN Authors: Pompilio Torremante Nils Kristian Berge Christel Weiss Source Type: research
IJERPH, Vol. 20, Pages 7107: The Dutch Pregnancy Drug Register: Suitable to Study Paternal Drug Exposures?
nbroek
Paternal medication use around the time of conception is common, but information about its effects on pregnancy outcome and the health of the child is generally limited. The aim of this study is to examine the feasibility of studying paternal exposure in the Dutch Pregnancy Drug Register by using immunosuppressants as a proof of concept. In 113 of 15,959 pregnancies, long-term paternal immunosuppressant use was reported 3 months before conception. In total, 134 immunosuppressants were used. Pregnancy outcome was known for 54 cases and was in accordance with previous findings. Two spontaneous abortions, two prema...
Source: International Journal of Environmental Research and Public Health - November 24, 2023 Category: Environmental Health Authors: Annerose E. van der Mijle Petra J. Woestenberg Leanne J. Kosse Eug ène P. van Puijenbroek Tags: Brief Report Source Type: research
Changes in Arterial Stiffness Monitored Using the Cardio-Ankle Vascular Index in Patients with Rheumatic Disease Receiving Initial Glucocorticoid Therapy: A Clinical Pilot Study
J Clin Med. 2023 Nov 3;12(21):6923. doi: 10.3390/jcm12216923.ABSTRACTSystemic inflammatory rheumatic diseases predispose to premature birth, accelerated atherosclerosis, and increased cardiovascular disease (CVD). While glucocorticoids (GCs) are used in various rheumatic diseases, and the associations between GC excess and increased prevalence of CVD complications are well established, the mechanisms underlying GCs' role in atheroma development are unclear. We conducted an observational study to address GC therapy's effect on arterial stiffness using the cardio-ankle vascular index (CAVI) in patients with rheumatic disease...
Source: Atherosclerosis - November 14, 2023 Category: Cardiology Authors: Kaichi Kaneko Daiki Sakai Shuji Sato Toshio Kinoshita Kazuhiro Shimizu Source Type: research
Changes in Arterial Stiffness Monitored Using the Cardio-Ankle Vascular Index in Patients with Rheumatic Disease Receiving Initial Glucocorticoid Therapy: A Clinical Pilot Study
J Clin Med. 2023 Nov 3;12(21):6923. doi: 10.3390/jcm12216923.ABSTRACTSystemic inflammatory rheumatic diseases predispose to premature birth, accelerated atherosclerosis, and increased cardiovascular disease (CVD). While glucocorticoids (GCs) are used in various rheumatic diseases, and the associations between GC excess and increased prevalence of CVD complications are well established, the mechanisms underlying GCs' role in atheroma development are unclear. We conducted an observational study to address GC therapy's effect on arterial stiffness using the cardio-ankle vascular index (CAVI) in patients with rheumatic disease...
Source: Atherosclerosis - November 14, 2023 Category: Cardiology Authors: Kaichi Kaneko Daiki Sakai Shuji Sato Toshio Kinoshita Kazuhiro Shimizu Source Type: research
Susceptibility of immature spiral ganglion neurons to aminoglycoside-induced ototoxicity is mediated by the TRPV1 channel in mice
This study aimed to investigate whether a nonselective cation channel, TRPV1, contributes to the susceptibility of immature spiral ganglion neurons (SGNs) to the damage caused by aminoglycosides. Through western blotting and immunofluorescence, we found that the TRPV1 expression levels were much higher in immature SGNs than in their mature counterparts. In postnatal day 7 cochlear organotypic cultures, AMG-517 reduced reactive oxygen species generation and inhibited SGN apoptosis under aminoglycoside challenge. However, in adult mice, AMG-517 did not ameliorate the ABR threshold increase at high frequencies (16 kHz and 32 ...
Source: Hearing Research - November 13, 2023 Category: Audiology Authors: Yijiang Bai Jing Liu Xuewen Wu Bo Pang Shuai Zhang Mengzhu Jiang Anhai Chen Huping Huang Yongjia Chen Yuan Zeng Lingyun Mei Kelei Gao Source Type: research
Susceptibility of immature spiral ganglion neurons to aminoglycoside-induced ototoxicity is mediated by the TRPV1 channel in mice
This study aimed to investigate whether a nonselective cation channel, TRPV1, contributes to the susceptibility of immature spiral ganglion neurons (SGNs) to the damage caused by aminoglycosides. Through western blotting and immunofluorescence, we found that the TRPV1 expression levels were much higher in immature SGNs than in their mature counterparts. In postnatal day 7 cochlear organotypic cultures, AMG-517 reduced reactive oxygen species generation and inhibited SGN apoptosis under aminoglycoside challenge. However, in adult mice, AMG-517 did not ameliorate the ABR threshold increase at high frequencies (16 kHz and 32 ...
Source: Hearing Research - November 13, 2023 Category: Audiology Authors: Yijiang Bai Jing Liu Xuewen Wu Bo Pang Shuai Zhang Mengzhu Jiang Anhai Chen Huping Huang Yongjia Chen Yuan Zeng Lingyun Mei Kelei Gao Source Type: research
Susceptibility of immature spiral ganglion neurons to aminoglycoside-induced ototoxicity is mediated by the TRPV1 channel in mice
This study aimed to investigate whether a nonselective cation channel, TRPV1, contributes to the susceptibility of immature spiral ganglion neurons (SGNs) to the damage caused by aminoglycosides. Through western blotting and immunofluorescence, we found that the TRPV1 expression levels were much higher in immature SGNs than in their mature counterparts. In postnatal day 7 cochlear organotypic cultures, AMG-517 reduced reactive oxygen species generation and inhibited SGN apoptosis under aminoglycoside challenge. However, in adult mice, AMG-517 did not ameliorate the ABR threshold increase at high frequencies (16 kHz and 32 ...
Source: Hearing Research - November 13, 2023 Category: Audiology Authors: Yijiang Bai Jing Liu Xuewen Wu Bo Pang Shuai Zhang Mengzhu Jiang Anhai Chen Huping Huang Yongjia Chen Yuan Zeng Lingyun Mei Kelei Gao Source Type: research
Susceptibility of immature spiral ganglion neurons to aminoglycoside-induced ototoxicity is mediated by the TRPV1 channel in mice
This study aimed to investigate whether a nonselective cation channel, TRPV1, contributes to the susceptibility of immature spiral ganglion neurons (SGNs) to the damage caused by aminoglycosides. Through western blotting and immunofluorescence, we found that the TRPV1 expression levels were much higher in immature SGNs than in their mature counterparts. In postnatal day 7 cochlear organotypic cultures, AMG-517 reduced reactive oxygen species generation and inhibited SGN apoptosis under aminoglycoside challenge. However, in adult mice, AMG-517 did not ameliorate the ABR threshold increase at high frequencies (16 kHz and 32 ...
Source: Hearing Research - November 13, 2023 Category: Audiology Authors: Yijiang Bai Jing Liu Xuewen Wu Bo Pang Shuai Zhang Mengzhu Jiang Anhai Chen Huping Huang Yongjia Chen Yuan Zeng Lingyun Mei Kelei Gao Source Type: research
Inactivated COVID-19 vaccines in peri-pregnancy period: Evaluation of safety for both pregnant women and neonates
CONCLUSION: The sensitivity analysis illustrates the robustness of our results, so we can conclude that the vaccination of inactivated COVID-19 vaccine during the peri-pregnancy period is safe for both the pregnant woman and neonates no matter what time of vaccination and the use of medication. In addition, it is recommended to monitor ALT levels throughout the first trimester of pregnancy.PMID:37949755 | DOI:10.1016/j.vaccine.2023.11.011 (Source: Vaccine)
Source: Vaccine - November 10, 2023 Category: Allergy & Immunology Authors: Caihua Yang Zengyue Zheng Ping Zheng Juan Chen Qianyun Huang Yue Chen Ying Zhou Pingyan Chen Yilei Li Ying Wu Source Type: research
Inactivated COVID-19 vaccines in peri-pregnancy period: Evaluation of safety for both pregnant women and neonates
CONCLUSION: The sensitivity analysis illustrates the robustness of our results, so we can conclude that the vaccination of inactivated COVID-19 vaccine during the peri-pregnancy period is safe for both the pregnant woman and neonates no matter what time of vaccination and the use of medication. In addition, it is recommended to monitor ALT levels throughout the first trimester of pregnancy.PMID:37949755 | DOI:10.1016/j.vaccine.2023.11.011 (Source: Vaccine)
Source: Vaccine - November 10, 2023 Category: Allergy & Immunology Authors: Caihua Yang Zengyue Zheng Ping Zheng Juan Chen Qianyun Huang Yue Chen Ying Zhou Pingyan Chen Yilei Li Ying Wu Source Type: research
Comparing the clinical and singleton neonatal outcomes in male infertility patients with Oligoasthenospermia, OA, or NOA following fresh ICSI-ET using different sources of sperm
Conclusion(s)Regardless of the type of male infertility (Oligoasthenospermia, OA, NOA) or sperm sources (ejaculate, epididymis, testis), a successful ICSI-ET procedure can result in similar clinical and neonatal outcomes, such as clinical pregnancy rate, live birth rate, abortion rate, neonatal birth weight and sex ratio of singleton pregnancies. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 8, 2023 Category: Endocrinology Source Type: research
Possible Rates of Detection of Neonatal Sepsis Pathogens in the Context of Microbiological Diagnostics in Mothers - Real World Data
CONCLUSION: In cases of neonatal sepsis, the sepsis-causing pathogen was successfully detected through prior analysis of a maternal smear in 7% of full-term infants and in 19% of premature infants. The number needed to test was relatively high in all groups. The value of maternal smears for identifying neonatal sepsis-causing pathogens needs to be critically questioned.PMID:37928410 | PMC:PMC10624541 | DOI:10.1055/a-2091-0856 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - November 6, 2023 Category: OBGYN Authors: Raffael Kuld Alexander Krauth Joachim K ühr Janine Kr ämer Ralf Dittrich Lothar H äberle Andreas M üller Source Type: research
Is carbon monoxide testing in pregnancy an acceptable and effective smoking cessation initiative? An integrative systematic review of evidence
CONCLUSION: Whilst carbon monoxide testing can identify smoking, it does not appear to motivate pregnant smokers to quit.PMID:37932159 | DOI:10.1016/j.wombi.2023.10.008 (Source: Women Birth)
Source: Women Birth - November 6, 2023 Category: Midwifery Authors: Emma Gaudron Deborah L Davis Source Type: research
