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Association of Sevelamer Initiation with Gastrointestinal Bleeding Hospitalization in Individuals Requiring Hemodialysis
Conclusion Among patients requiring hemodialysis, sevelamer (vs non-sevelamer) containing phosphate binders was not associated with increased risk of GIB hospitalization.PMID:38555633 | DOI:10.1159/000538253 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 31, 2024 Category: Urology & Nephrology Authors: Dustin Le Deidra C Crews Morgan E Grams Josef Coresh Jung-Im Shin Source Type: research

Tenascin-X is increased with decreased expression of miR-378a-5p and miR-486-5p in mice fed a methionine-choline-deficient diet that induces hepatic fibrosis
In this study, we investigated Tnxb expression in livers with fibrosis caused by administration of a methionine-chorine-deficient (MCD) diet in mice. Whole transcriptome analysis showed that Tnxb was one of the genes with increased expression in livers of MCD diet-fed mice compared with that in livers of normal diet (ND)-fed mice. In microarray and subsequent microRNA (miRNA) network analyses, miR-378a-5p and miR-486-5p were identified in livers of MCD diet-fed mice as downregulated miRNAs, which have their predicted target sites in the 3' untranslated region of Tnxb mRNA and might suppress the translation of Tnxb mRNA. RT...
Source: Biomed Res - March 31, 2024 Category: Research Authors: Ken-Ichi Matsumoto Takuma Higuchi Mirei Umeki Masafumi Ono Shuji Sakamoto Source Type: research

Microflow, Sequential Coupling and Cyclization Approach for Synthesis of Cyclic Phosphotriesters from PCl3
Chem Asian J. 2024 Mar 31:e202400256. doi: 10.1002/asia.202400256. Online ahead of print.ABSTRACTAn approach for the synthesis of cyclic phosphotriesters with various ring sizes (5- to 8-membered rings) from phosphorus trichloride and diols was developed. The major challenge in developing this approach is the suppression of the undesired reactions caused by substrates containing multiple highly reactive sites. These undesired reactions were successfully suppressed by microflow technology, which can precisely control the reaction time and temperature. Two optimal conditions were developed, depending on the speed of cyclizat...
Source: Chemistry, an Asian Journal - March 31, 2024 Category: Chemistry Authors: Kohei Nakabayashi Hiroshi Kitamura Shinichiro Fuse Source Type: research

Metals and phosphorus in the sediments of streams emptying into the Çanakkale strait (Dardanelles): Spatial distribution, pollution status, risk assessment and source identification
This study can provide an important reference for evaluating stream sediment pollution and managing marine pollution.PMID:38555082 | DOI:10.1016/j.envres.2024.118795 (Source: Environmental Research)
Source: Environmental Research - March 30, 2024 Category: Environmental Health Authors: Memet Varol Cem Tokatl ı Source Type: research

Sequential removal of phosphate and copper(II) ions using sustainable chitosan biosorbent
Int J Biol Macromol. 2024 Mar 28:131178. doi: 10.1016/j.ijbiomac.2024.131178. Online ahead of print.ABSTRACTAlthough adsorbents are good candidates for removing phosphorus and heavy metals from wastewater, the use of biosorbents for the sequential treatment of phosphorus and copper has not yet been studied. Porous chitosan (CS)-based biosorbents (CGBs) were developed to adsorb phytic acid (PA), a major form of organic phosphate. This first adsorbate (PA) further served as an additional ligand (P-type ligand) for the CGBs (N-type ligand) to form a complex with the second adsorbate (copper). After the adsorption of PA (the f...
Source: International Journal of Biological Macromolecules - March 30, 2024 Category: Biochemistry Authors: Fwu-Long Mi Wen-Yi Chen Zhi-Run Chen I-Wen Chang Shao-Jung Wu Source Type: research

Metallomic mapping of gut and brain in heavy metal exposed earthworms: A novel paradigm in ecotoxicology
This study explored the uptake of lead in the epigeic earthworm Dendrobaena veneta exposed to 0, 1000, and 2500 μg Pb/g soil. The soil metal content was extracted using strong acid digestion and water leaching, and analysed by means of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to estimate absolute and bioavailable concentrations of metals in the soil. The guts and heads of lead-exposed earthworms were processed into formalin-fixed and paraffin embedded sections for high-resolution multi-element metallomic imaging via Laser Ablation ICP-MS (LA-ICP-MS). Metallomic maps of phosphorus, zinc, and lead were produced...
Source: Biochemical and Biophysical Research communications - March 30, 2024 Category: Biochemistry Authors: Maxim A Karpov Carl Hobbs Suwan N Jayasinghe Stephen R St ürzenbaum Source Type: research

GSE259442 Exploring the Dynamic Adaptive Responses of Epimedium pubescens to Phosphorus Deficiency Through Combined Transcriptome and miRNA Analysis [RNA-Seq]
Contributors : Shangnian Liu ; Xiaojing AnSeries Type : Expression profiling by high throughput sequencingOrganism : Epimedium pubescensIn the early stages (30 days) of phosphorus deficiency stress, Epimedium pubescens leaves cope with short-term phosphorus deficiency by increasing the expression of related genes such as carbon metabolism, flavonoid synthesis and hormone signal transduction pathways, producing sufficient energy, scavenging ROS, and adjusting plant morphology. However, with the extension of stress duration to 90 days, the expression of genes related to phosphorus cycling and phosphorus recovery (PHT1-4, P...
Source: GEO: Gene Expression Omnibus - March 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Epimedium pubescens Source Type: research

GSE259444 Exploring the Dynamic Adaptive Responses of Epimedium pubescens to Phosphorus Deficiency Through Combined Transcriptome and miRNA Analysis [miRNA-Seq]
Contributors : Shangnian Liu ; Xiaojing AnSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Epimedium pubescensIn the early stages (30 days) of phosphorus deficiency stress, Epimedium pubescens leaves cope with short-term phosphorus deficiency by increasing the expression of related genes such as carbon metabolism, flavonoid synthesis and hormone signal transduction pathways, producing sufficient energy, scavenging ROS, and adjusting plant morphology. However, with the extension of stress duration to 90 days, the expression of genes related to phosphorus cycling and phosphorus recovery (PHT1-...
Source: GEO: Gene Expression Omnibus - March 30, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Epimedium pubescens Source Type: research