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Safety of cinacalcet in children and adolescents with chronic kidney disease-mineral bone disorder: systematic review and proportional meta-analysis of case series
Conclusions and implications of key findingsIf used in the pediatric population, the calcimimetic cinacalcet should be carefully monitored for serum calcium levels and attention to possible adverse events, especially in children under 50 months.Systematic review registration number (PROSPERO register)CRD42019132809. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 9, 2024 Category: Urology & Nephrology Source Type: research

Effect of Antenatal Oral Vitamin D Supplementation on Serum 25(OH)D Concentration in Exclusively Breastfed Infants at 6 Months of age - A Randomized Double-Blind Placebo-Controlled Trial
CONCLUSIONS: Oral supplementation of vitamin D3 to pregnant women in the third trimester prevents severe hypovitaminosis D in the EBF infants at 6-months of age.PMID:38584410 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 8, 2024 Category: Pediatrics Authors: Prashant Prabhakar M M A Faridi Anju Aggarwal Rachna Aggarwal S V Madhu Rajeev Malhotra Source Type: research

Protective effects of sodium butyrate on fluorosis in rats by regulating bone homeostasis and serum metabolism
In this study, a rat model of fluorosis induced by 100 mg/L sodium fluoride was used to investigate the impact of NaB on bone homeostasis and serum metabolomics. It was found that NaB significantly reduced the levels of bone resorption markers CTX-Ⅰ and TRACP-5B in fluorosis rats. Moreover, NaB increased calcium and magnesium levels in bone, while decreasing phosphorus levels. In addition, NaB improved various bone microstructure parameters, including bone mineral density (BMD), trabecular thickness (Tb. Th), trabecular bone separation (Tb. SP), and structural model index (SMI) in the femur. Notably, NaB intervention als...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Ying Li Fengmei Yang Jie Liu Mengqi Jiang Ye Yu Qingyi Zhou Lu Sun Zhuo Zhang Lin Zhou Source Type: research

The effect of quorum sensing on cadmium- and lead-containing wastewater treatment using activated sludge: Removal efficiency, enzyme activity, and microbial community
This study offers valuable insights into the mechanisms underlying Cd(II) and Pb(II) removal as well as microbial community succession under AHL availability in industrial wastewater.PMID:38582423 | DOI:10.1016/j.envres.2024.118835 (Source: Environmental Research)
Source: Environmental Research - April 6, 2024 Category: Environmental Health Authors: Taotao Zeng Liangqin Wang Xiaoya Ren Naif Abdullah Al-Dhabi Haichao Sha Yusong Fu Wangwang Tang Jie Zhang Source Type: research

Inhibitory effects of black phosphorus nanosheets on tumor cell proliferation through downregulation of ADIPOQ and downstream signaling pathways
Chem Biol Interact. 2024 Apr 4:110994. doi: 10.1016/j.cbi.2024.110994. Online ahead of print.ABSTRACTExposure to environmental pollutants, including nanomaterials, has a significant impact on tumor progression. The increased demand for black phosphorus nanosheets (BPNSs), driven by their exceptional properties, raises concerns about potential environmental contamination. Assessing their toxicity on tumor growth is essential. Herein, we employed a range of biological techniques, including cytotoxicity measurement, bioinformatics tools, proteomics, target gene overexpression, Western blot analysis, and apoptosis detection, t...
Source: Chemico-Biological Interactions - April 6, 2024 Category: Molecular Biology Authors: Daxu Liu Qing Zhao Zhaoxu Tu Siyu Zhang Shuo Deng Zhiqiang Xiong Jin Zeng Fengchang Wu Xuejiao Zhang Baoshan Xing Source Type: research

Insect poetry, conquering rats, and more stories you might have missed this week
Have we gotten bird evolution all wrong? Why did scientists make mouse brains glow? And how did thousands upon thousands of skeletons vanish from Napoleonic-era battlefields? Check out the answers below in some of our favorite selections from Science ’s daily newsletter, Science Adviser . A new way to light up oxygen in the brain We need to breathe because our cells do, too. Brain cells, for example, use about one-fifth of all the oxygen your body consumes. But scientists know relatively little about what oxygen flow in the brain looks like because it�...
Source: Science of Aging Knowledge Environment - April 5, 2024 Category: Geriatrics Source Type: research

An Air-Stable Storage Compound for White Phosphorus: Reversible Addition to a Stannylene and Chemical Release of P4
Chem Asian J. 2024 Apr 5:e202400168. doi: 10.1002/asia.202400168. Online ahead of print.ABSTRACTControlled insertion into a single P-P bond of white phosphorus (P4) was achieved by employing a diaryl stabilized stannylene, Ar*2Sn (Ar* = 2,6-bis(benzhydryl)-4-iPr-phenyl). Conversions of the stannylene with P4 gave a non-pyrophoric, air-stable storage compound, which releases P4 quantitively upon irradiation with light (354 or 455 nm). Alternatively, the phosphorus cage is detached by reacting the storage compound with PhChChPh (Ch = Se, Te). Despite the recent advances in the directed conversion of P4 using main group eleme...
Source: Chemistry, an Asian Journal - April 5, 2024 Category: Chemistry Authors: Beate G Steller Clara A Roller Michaela Flock Roland C Fischer Source Type: research

Pollution load estimation and influencing factor analysis in the Tuhai River Basin in Shandong Province of China based on improved output coefficient method
This study utilized the improved output coefficient method to estimate the total pollution loads in the river basin while analyzing the influencing factors based on the STIRPAT (Stochastic Impacts by Regression on Population, Affluence, and Technology) model. Findings indicated that the projected point source pollution loads for total phosphorus (TP), chemical oxygen demand (COD), and ammonia nitrogen (AN) would amount to 3937.22 ton, 335,523.25 ton, and 13,946.92 ton in 2021, respectively. Among these, COD pollution would pose the greatest concern. The primary contributors to the pollution loads were rural scattered life,...
Source: Environmental Science and Pollution Research International - April 5, 2024 Category: Environmental Health Authors: Xi Wang Xiaoyu Zhang Xiaomei Gao Shifan Dong Yushuo Zhang Weiying Xu Source Type: research

Domestic wastewater sludge valorization: Multi-criteria evaluation of anaerobic digestion vs. hydrothermal liquefaction
Bioresour Technol. 2024 Apr 3:130655. doi: 10.1016/j.biortech.2024.130655. Online ahead of print.ABSTRACTThe emerging hydrothermal liquefaction (HTL) process is evaluated against the classical anaerobic digestion (AD) processes for stabilizing wastewater sludges and recovering their energy- and nutrient-contents. Although HTL affords faster stabilization, better process stability, and liquid fuel and sterile fertilizer recovery, it suffers from higher energy demand and lower technology readiness level. For a rational comparison of these pathways, a multi-criteria evaluation is conducted considering 21 technical, environmen...
Source: Bioresource Technology - April 5, 2024 Category: Biotechnology Authors: W M L K Abeyratne Y Zhang C E Brewer N Nirmalakhandan Source Type: research