How to tame a toxic yet life-saving antifungal
In this episode:00:46 Modifying a fungal drug to make it less toxicAmphotericin B is a drug used to treat life-threatening fungal infections. But while it is effective against many fungal species, it is also extremely toxic to kidneys, meaning it is mostly used as a drug of last-resort. This week, a team has unpicked the mechanism behind the drug’s toxicity, allowing them to modify it and reduce side effects in human kidney cells. The researchers hope this new version of the drug could become a useful tool in fighting fungal diseases.Research article: Maji et al.09:00 Research HighlightsReconstructing woolly rhino DNA us...
Source: Nature Podcast - November 8, 2023 Category: Science Authors: Springer Nature Limited Source Type: podcasts
