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Efficacy and safety of proton pump inhibitors on cardiovascular events and inflammatory factors in patients with upper gastrointestinal bleeding undergoing dual antiplatelet therapy
ConclusionMelena was the most frequent clinical manifestation in UGIB patients. The use of PPIs did not increase the risk of CVEs, and different PPI drugs did not affect the occurrence of CVEs. Furthermore, PPIs lowered CRP and TNF- α levels in serum of these patients. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 20, 2024 Category: Drugs & Pharmacology Source Type: research

Longer-Duration Dual Antiplatelet Therapy in Medically-Treated Myocardial Infarction: What is the Strength of the Evidence?
A few studies have demonstrated the benefit of dual antiplatelet therapy (DAPT) during the first 3 to 12 months after acute myocardial infarction (AMI) in medically managed patients.1 –3 However, the benefit of more prolonged DAPT is poorly defined. The guidelines from national societies on the use of antiplatelet therapy after acute coronary syndromes (ACS) with or without percutaneous coronary intervention (PCI)/stenting continue to evolve, with more recent guidelines recomme nding a reduced duration and intensity of therapy in certain situations. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 20, 2024 Category: Cardiology Authors: Jeffrey L. Anderson Tags: Editorial Source Type: research

Longer Duration DAPT in Medically Treated MI: What is the Strength of the Evidence?
A few studies have demonstrated the benefit of dual antiplatelet therapy (DAPT) during the first 3-12 months after AMI in medically managed patients (1-3). However, the benefit of more prolonged DAPT is poorly defined. The guidelines from national societies on the use of antiplatelet therapy after acute coronary syndromes (ACS) with or without percutaneous coronary intervention (PCI)/stenting continue to evolve, with more recent guidelines recommending a reduced duration and intensity of therapy in certain situations (4, 5). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 20, 2024 Category: Cardiology Authors: Jeffrey L Anderson Tags: Editorial Source Type: research

How much data is enough data for imaging-guided PCI?
It is almost unanimously acknowledged that imaging guided percutaneous coronary intervention (PCI) improves outcomes, particularly in complex cases, where there's a mortality reduction of up to 50% [1,2]. Numerous studies have permeated the interventional landscape, that it is very difficult not to recommend intracoronary imaging when embarking on a more complex PCI. Just as no one questions the prescription of statins, for example, which reduce all-cause mortality by approximately 20 –30% (for both primary and secondary prevention) [3–5]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 20, 2024 Category: Cardiology Authors: Alexandru Achim Source Type: research

Outcomes of Percutaneous Revascularization in Severe Ischemic Left Ventricular Dysfunction
This article presents a comprehensive review of coronary revascularization versus optimal medical therapy (OMT) in patients with severe ischemic left ventricular dysfunction.Recent FindingsThe REVIVED-BCIS2 trial randomized 700 patients with extensive coronary artery disease and left ventricular (LV) ejection fraction (LVEF) ≤ 35% and viability in more than four dysfunctional myocardial segments to percutaneous coronary intervention (PCI) plus OMT versus OMT alone. Over a median duration of 41 months, there was no difference in the composite of all-cause mortality, heart failure hospitalization, or improvement i n ...
Source: Current Cardiology Reports - April 20, 2024 Category: Cardiology Source Type: research

Prognostic value of triglyceride-glucose index for left ventricular remodeling in nondiabetic ST-elevation myocardial infarction patients
Conclusion: A high TyG index level may contribute to the prediction of LVR in nondiabetic STEMI patients undergoing successful primary percutaneous coronary intervention.PMID:38639732 | DOI:10.2217/bmm-2024-0015 (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 19, 2024 Category: Internal Medicine Authors: Tolga Han Efe Engin Alg ül Source Type: research

Impact of baseline yellow plaque assessed by coronary angioscopy on vascular response after stent implantation
CONCLUSIONS: Baseline YP affected the incidence of neoatherosclerosis as well as poor neointimal coverage at 11 months after stent implantation.PMID:38641319 | DOI:10.1016/j.jjcc.2024.04.004 (Source: Journal of Cardiology)
Source: Journal of Cardiology - April 19, 2024 Category: Cardiology Authors: Takuya Tsujimura Isamu Mizote Takayuki Ishihara Daisuke Nakamura Naotaka Okamoto Tatsuya Shiraki Naoki Itaya Mitsuyoshi Takahara Takaharu Nakayoshi Osamu Iida Yosuke Hata Masami Nishino Takafumi Ueno Daisaku Nakatani Shungo Hikoso Shinsuke Nanto Toshiaki Source Type: research

Evaluation on mortality predictors after emergent percutaneous coronary intervention in acute myocardial infarction with ventricular arrhythmias: Details not to be ignored?
We have read the article “Predictors of 30-day survival after emergent percutaneous coronary intervention following ventricular tachyarrhythmias complicating acute myocardial infarction” by Kohei Ukita et al [1]. In the study Immediate CPR and single-vessel CAD were significant predictors of 30-day survival after emerge nt PCI following VF or pulseless VT complicating AMI in patients . In univariate analysis, absence of diabetes and low arterial lactate value were associated with 30-day survival. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 19, 2024 Category: Cardiology Authors: Aytu ğ Al, Erdi Babayiğit, Bülent Görenek Source Type: research

Clinical and economic outcomes of assigning percutaneous coronary intervention patients to contrast-sparing strategies based on the predicted risk of contrast-induced acute kidney injury
CONCLUSIONS.: Assignment to contrast-sparing regimens at a predicted risk threshold close to the underlying incidence of CI-AKI is projected to result in significant clinical and economic benefits.PMID:38632967 | DOI:10.1080/13696998.2024.2334180 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 18, 2024 Category: Health Management Authors: Robert I Griffiths Aparna Bhave Alysha M McGovern Liesl M Hargens Craig A Solid Amit P Amin Source Type: research

Isthmin-1 alleviates cardiac ischemia/reperfusion injury through cGMP-PKG signaling pathway
CONCLUSION: ISM1 can protect against cardiac I/R injury through cGMP-PKG signaling pathway, and it is a promising therapeutic and predictive target of cardiac I/R injury.PMID:38637328 | DOI:10.1093/cvr/cvae077 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Min Hu Xin Zhang Can Hu Zhen-Guo Ma Sha-Sha Wang Teng Teng Xiao-Feng Zeng Qi-Zhu Tang Source Type: research

A randomised multicentre study of angiography- versus physiologyguided percutaneous coronary intervention in patients with coronary artery disease undergoing TAVI: design and rationale of the FAITAVI trial
EuroIntervention. 2024 Apr 15;20(8):e504-e510. doi: 10.4244/EIJ-D-23-00679.ABSTRACTThe treatment of coronary artery disease (CAD) in patients with severe aortic valve stenosis (AVS) eligible for transcatheter aortic valve implantation (TAVI) is not supported by clinical evidence, and the role of physiology over anatomy as well as the timing of coronary intervention are not defined. FAITAVI (ClinicalTrials.gov: NCT03360591) is a nationwide prospective, open-label, multicentre, randomised controlled study comparing the angiography-guided versus the physiology-guided coronary revascularisation strategy in patients with combin...
Source: EuroIntervention - April 17, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Flavio Ribichini Gabriele Pesarini Tommaso Fabris Mattia Lunardi Marco Barbierato Gianpiero D'Amico Chiara Zanchettin Dario Gregori Tommaso Piva Elisa Nicolini Caterina Gandolfo Massimo Fineschi Anna Sonia Petronio Sergio Berti Francesco Caprioglio France Source Type: research

Patient characteristics associated with acute kidney injury following coronary angiography
CONCLUSION: Peripheral artery disease, multivessel disease, and creatinine >1.5 mg/dL were associated with a higher risk of AKI in patients undergoing coronary angiography in this single-center retrospective cohort.PMID:38628321 | PMC:PMC11018084 | DOI:10.1080/08998280.2024.2301903 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - April 17, 2024 Category: Universities & Medical Training Authors: Jonathan Knott Michael Engheta Jeffery Michel Timothy Mixon R Jay Widmer Source Type: research

Comprehensive Cardiac Rehabilitation Following Acute Myocardial Infarction Improves Clinical Outcomes Regardless of Exercise Capacity
CONCLUSIONS: Comprehensive CR in patients with AMI effectively reduced the incidence of MACE regardless of initial exercise capacity. Cardiologists should actively encourage patients with low exercise capacity to participate in comprehensive CR.PMID:38631882 | DOI:10.1253/circj.CJ-23-0668 (Source: Circulation Journal)
Source: Circulation Journal - April 17, 2024 Category: Cardiology Authors: Takashi Hiruma Atsuko Nakayama Junko Sakamoto Kentaro Hori Mamoru Nanasato Toru Hosoda Mitsuaki Isobe Source Type: research