Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer.
Conclusion: DUSP4 transcripts have the potential to serve as diagnostic biomarkers for CRC, particularly variant X1. PMID: 32613839 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - July 4, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Leukocyte telomere length: a potential biomarker for the prognosis of coronary artery disease.
This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). Materials & methods: We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). Results: CAD patients had a significantly shortened LTL compared with healthy subjects (p 
Source: Future Medicine: Biomarkers in Medicine - July 4, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Exploring serum metabolic markers for the discrimination of ccRCC from renal angiomyolipoma by metabolomics.
Conclusion: The alterations of serum purine metabolites may be used as potential metabolic markers for the differential diagnosis of ccRCC and RAML. PMID: 32613842 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - July 4, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Downregulation of reelin predicts poor prognosis for glioma.
Conclusion: RELN may serve as a potential prognostic marker and promising target molecule for new therapy of glioma. PMID: 32613843 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - July 4, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Urine headspace analysis with field asymmetric ion mobility spectrometry for detection of chronic kidney disease.
Conclusion: In this preliminary study, applying eNose technology we were able to distinguish the patients with impaired kidney function from those with normal kidney function. PMID: 32613848 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - July 4, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Krebs von den Lungen-6 as biomarker for disease severity assessment in interstitial lung disease: a comprehensive review.
Conclusion: KL-6 is predictive biomarker useful in the clinical management of ILD patients, in particular in patients with severe fibrotic lung disorders. PMID: 32613855 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - July 4, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Serum AMDL DR-70 levels: a new concept in diagnosis and follow-up of colorectal carcinoma.
Conclusion: It can be concluded that serum levels of DR-70 can be regarded as an indicator for the diagnosis of colorectal cancer. PMID: 32608998 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - July 3, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Advanced glycation end products as biomarkers for cardiovascular disease: browning clarifying atherogenesis.
Authors: Pinto RS, Machado UF, Passarelli M PMID: 32530293 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - June 14, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Personalized prediction of human diseases with single-sample dynamic network biomarkers.
Authors: Fang Z, Chen L PMID: 32530294 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - June 14, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19.
This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Results: An increase in the severity of COVID-19 pneumonia was positively associated with lower levels of platelets and albumin (all p 
Source: Future Medicine: Biomarkers in Medicine - June 4, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

HSP90 ╬▒ combined with AFP and TK1 improved the diagnostic value for hepatocellular carcinoma.
Conclusion: The detection of HSP90α, AFP and TK1 is more efficient than a single tumor marker for the diagnosis of HCC. PMID: 32490681 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - June 4, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

The aegis: platelets as biomarkers of tumor progression.
Authors: N Augustine T Abstract There is increasing awareness that platelets play a significant role in creating a hypercoagulable environment that mediates tumor progression, beyond their classical hemostatic function. Platelets have heterogenic responses to agonists, and differential release and uptake of bioactive molecules may be manipulated via reciprocal cross-talk with cells of the tumor microenvironment. Platelets thus promote tumor progression by enhancing tumor growth, promoting the development of tumor-associated vasculature and encouraging invasion. In the metastatic process, platelets form the shield t...
Source: Future Medicine: Biomarkers in Medicine - May 29, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Prognostic significance of C-MYC dysregulation in esophageal squamous cell carcinoma: a meta-analysis.
Authors: Shi X, Zhou R, Zheng L, Jiang M Abstract Aim: The clinicopathological and prognostic significance of C-MYC dysregulation (amplification or overexpression) in esophageal squamous cell carcinoma (ESCC) remains controversial. Therefore, we performed this meta-analysis to elucidate this relationship. Materials & methods: Available studies were retrieved from PubMed, Web of Science, EMBASE and the Cochrane Library, and ten studies with a total of 1432 patients were included in this meta-analysis. Results: Pooled results showed that C-MYC dysregulation was significantly associated with poor overall...
Source: Future Medicine: Biomarkers in Medicine - May 29, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Clinical significance of miR-33b in glioma and its regulatory role in tumor cell proliferation, invasion and migration.
Conclusion: Decreased expression of miR-33b serves a promising biomarker in the diagnosis and prognosis of glioma, and may be a potential therapeutic target. PMID: 32462908 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - May 29, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Osteopontin as novel biomarker for reversibility of pressure overload induced left ventricular hypertrophy.
Conclusion: OPN may be a useful indicator for LV hypertrophy phenotype and could have a prognostic value to estimate LV-mass regression after SAVR. PMID: 32462909 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - May 29, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

How biomarkers can improve pneumonia diagnosis and prognosis: procalcitonin and mid-regional-pro-adrenomedullin.
Authors: Spoto S, Legramante JM, Minieri M, Fogolari M, Terrinoni A, Valeriani E, Sebastiano C, Bernardini S, Ciccozzi M, Angeletti PS Abstract Aim: The diagnostic and prognostic role of procalcitonin (PCT) and mid-regional-pro-adrenomedullin (MR-proADM) were investigated in patients with pneumonia. Material & methods: A total of 168 and 77 patients with pneumonia enrolled in two different hospital settings, an internal medicine unit and an emergency unit were included in the study. PCT and MR-proADM plasma concentrations and pneumonia severity index score were measured. Median values were compared by...
Source: Future Medicine: Biomarkers in Medicine - May 29, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Application of a machine learning-driven, multibiomarker panel for prediction of incident cardiovascular events in patients with suspected myocardial infarction.
Conclusion: Among patients with suspected MI, we validated a multibiomarker panel for predicting 1-year MACE. ClinicalTrials.gov identifier: NCT02355457. PMID: 32462911 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - May 29, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Integrative meta-analysis for the identification of hub genes in chemoresistant colorectal cancer.
Conclusion: Our findings show that HNF4A could be a potential target in overcoming FOLFOX chemoresistance in colorectal cancer. PMID: 32462912 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - May 29, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Circular RNAs: new genetic tools in melanoma.
Authors: Hallajzadeh J, Amirani E, Mirzaei H, Shafabakhsh R, Mirhashemi SM, Sharifi M, Yousefi B, Mansournia MA, Asemi Z Abstract Melanoma is the most lethal form of skin cancer. New technologies have resulted in major advances in the diagnosis and treatment of melanoma and other cancer types. Recently, some studies have investigated the role of circular RNAs (circRNAs) in different cancers. CircRNAs are a member of long noncoding RNA family mainly formed through back-splicing and have a closed loop structure. These molecules affect several biological and oncogenic cascades in diverse ways via acting as microRNA sp...
Source: Future Medicine: Biomarkers in Medicine - May 29, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Cardiovascular disease as a biomarker for an increased risk of COVID-19 infection and related poor prognosis.
Authors: Ielapi N, Licastro N, Provenzano M, Andreucci M, Franciscis S, Serra R PMID: 32426991 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - May 21, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Exhaled nitric oxide as a clinical biomarker for choosing biologics for severe asthma treatment.
Authors: Fuschillo S, Heffler E, Maniscalco M PMID: 32378424 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - May 9, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Thymidine kinase-1 as a biomarker in breast cancer: estimating prognosis and early recognition of treatment resistance.
Authors: McCartney A, Malorni L PMID: 32378432 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - May 9, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Relationship between mild renal dysfunction and coronary artery disease in young patients with stable angina pectoris.
Authors: Duran M, Elcik D, Inanc MT, Yarl─▒oglues M, Celik IE, Oksuz F, Murat S Abstract Aim: We investigated the relationship between mild renal dysfunction (MRD) and the presence of coronary artery disease (CAD) in people under 60. Materials & methods: A total of 634 (317 patients with vessel stenosis ≥50% and 317 with normal angiography) individuals diagnosed with stable angina pectoris and estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 were included in the present study. Results: The mean eGFR was lower (95.3 ± 23.7 vs 109.7 ± 22.3,...
Source: Future Medicine: Biomarkers in Medicine - April 11, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Biomarkers for pediatric cancer detection: latest advances and future perspectives.
Authors: Stachowicz-Stencel T, Synakiewicz A Abstract Cancer is one of the major health problems of the modern world. With the development of novel biochemistry and analytical instrumentation, precancer diagnosis has become a major focus of clinical and preclinical research. Finding appropriate biomarkers is crucial to make an early diagnosis, before the disease fully develops. With the improvement of precancer studies, cancer biomarkers prove their usefulness in providing important data on the cancer type and the status of patients' progression at a very early stage of the disease. Due to the constant evolution of...
Source: Future Medicine: Biomarkers in Medicine - April 11, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Methods for rapid diagnosis of meningitis etiology in adults.
Authors: Poplin V, Boulware DR, Bahr NC Abstract Infectious meningitis can be caused by viral, bacterial or fungal pathogens. Despite widely available treatments, many types of infectious meningitis are still associated with significant morbidity and mortality. Delay in diagnosis contributes to poor outcomes. Cerebrospinal fluid cultures have been used traditionally but are time intensive and sensitivity is decreased by empiric treatment prior to culture. More rapid techniques such as the cryptococcal lateral flow assay (IMMY), GeneXpert MTB/Rif Ultra (Cepheid) and FilmArray multiplex-PCR (Biofire) are three exampl...
Source: Future Medicine: Biomarkers in Medicine - April 11, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Cardiac troponin had limited diagnostic value for acute myocardial infarction in renal insufficiency: a meta-analysis.
Conclusion: The usual and optimized cut-off threshold for cTn had decreased diagnostic efficacy for acute myocardial infarction. Serial sampling seemed to increase the diagnostic efficiency. PMID: 32270694 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 11, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Diagnostic value of HOX transcript antisense RNA for cancer detection: a meta-analysis.
Conclusion: Long noncoding RNA HOX transcript antisense RNA may be a useful biomarker for cancer detection. PMID: 32270696 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 11, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Associations between TAB2 gene polymorphisms and dilated cardiomyopathy in a Chinese population.
Conclusion: TAB2 gene polymorphisms were associated with DCM susceptibility and prognosis in the Chinese population. PMID: 32270697 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 11, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Basic knowledge on BCR-ABL1-positive extracellular vesicles.
Authors: Jurj A, Pasca S, Teodorescu P, Tomuleasa C, Berindan-Neagoe I Abstract Chronic myelogenous leukemia (CML) is a hematological malignancy characterized by the excessive proliferation of myeloid progenitors. In the case of CML, these extracellular vesicles (EVs) were shown to communicate with hematopoietic stem cells, mesenchymal stem cells, myeloid derived suppressor cells and endothelial cells determining a beneficial microenvironment for the CML clone. Moreover, as these EVs are marked through BCR-ABL1, they were shown to be useful in clinical research in determining the grade of molecular remission with f...
Source: Future Medicine: Biomarkers in Medicine - April 11, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Identification of potential crucial genes associated with the pathogenesis and prognosis of prostate cancer.
Conclusion: The nine-gene signature was correlated with drug sensitivity, mutational landscape, immune infiltrates, clinical characteristics and survival from PCa. PMID: 32253914 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 9, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

C-reactive protein in saliva and dried blood spot as markers of stress reactivity in healthy African Americans.
Conclusion: Noninvasive measures of CRP reactivity may be only moderately related to one another in stress reactivity contexts. PMID: 32253920 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 9, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

The performance of the SHOX2/PTGER4 methylation assay is influenced by cancer stage, age, type and differentiation.
Conclusion: The mSHOX2/mPTGER4 assay showed some values with more limitations in lung cancer early detection. PMID: 32250153 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 8, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Circulating tumor-specific DNA: a stony road to clinical utility.
Authors: Thomsen CB, Jakobsen A PMID: 32250154 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 8, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

The role of epithelial-mesenchymal transition markers in the prediction of lymph node metastases in colorectal cancer.
Authors: Nazemalhosseini-Mojarad E, Sanjabi F, Babini H PMID: 32250155 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 8, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

SLC2A4 expression and its epigenetic regulation as biomarkers for insulin resistance treatment in diabetes mellitus.
Authors: Esteves JV, Yonamine CY, Machado UF PMID: 32250156 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 8, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Predictive and patient-monitoring biomarkers: precision in the management of colorectal cancer.
Authors: Pappas-Gogos G, Baltagiannis EG, Kyrochristos ID, Ziogas DE, Goussia A, Mitsis M, Roukos DH PMID: 32250157 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - April 8, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Prognostic value of AKAP13 methylation and expression in lung squamous cell carcinoma.
Conclusion: AKAP13 mRNA and its methylated CpG sites are potential prognostic indicators in LUSC patients. PMID: 32208871 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - March 28, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

COX-2 promotes metastasis and predicts prognosis on gastric cancer via regulating mTOR.
Conclusion: The combined expression of COX-2 and mTOR could serve as efficient prognostic indicators and COX-2 could suppress GC metastasis via regulating mTOR. PMID: 32175764 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - March 18, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Mean platelet volume/platelet count ratio predicts long-term mortality in patients with infective endocarditis.
Conclusion: Elevated MPR was independently associated with long-term all-cause mortality in patients with IE. PMID: 32166976 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - March 15, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Interaction analysis of miR-1275/IGF2BP1/IGF2BP3 with the susceptibility to hepatocellular carcinoma.
Conclusion: The rs16759, rs11079850 and rs34414305 may singly and interactively contribute to carcinogenesis of HCC. PMID: 32134323 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - March 8, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Mean corpuscular hemoglobin concentration correlates with prognosis of resected hepatocellular carcinoma.
Authors: Kong W, Zheng J, Chen L, Zuo X, Wang H, Wang X, Yao J, Chen W Abstract Aim: To evaluate the prognostic role of mean corpuscular hemoglobin concentration (MCHC) in hepatocellular carcinoma (HCC) after hepatectomy. Patients & methods: A total of 289 HCC patients were classified into two groups based on the cut-off value of MCHC. Significant prognostic factors were screened by univariate and multivariate analysis. Results: Low MCHC value was significantly associated with tumor diameter (p = 0.004) and vascular invasion (p = 0.038). Besides, Cox regression analysis showed that low MCHC ...
Source: Future Medicine: Biomarkers in Medicine - March 8, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Significance of lncRNA MIR31HG in predicting the prognosis for Chinese patients with cancer: a meta-analysis.
Authors: Zhou Y, Fan Y, Zhou X, Mou A, He Y, Wang F, Liu Y Abstract It is important to clarify the significance of long noncoding RNA MIR31 host gene (lncRNA MIR31HG) in predicting the prognosis for malignant tumors through meta-analysis. Electronic databases were systemically searched, from inception until 2 January 2019, to identify related articles. Meanwhile, the hazard ratios (odds ratios) and 95% CIs were computed for exploring the association between the expression of lncRNA MIR31HG and the survival (pathological variables). Eleven studies with 1041 cases were enrolled into the current meta-analysis. Low exp...
Source: Future Medicine: Biomarkers in Medicine - March 8, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for the diagnosis and prognosis in patients with restenosis following CAS.
Conclusion: Therefore, NLR can be utilized as an independent prognostic indicator to predict the incidence of restenosis after CAS procedures. PMID: 32134328 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - March 8, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Prognostic value of cripto-1 expression in non-small-cell lung cancer patients: a systematic review and meta-analysis.
Conclusion: Cripto-1 could serve as a novel biomarker for predicting poor prognosis in NSCLC patients. PMID: 32134335 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - March 8, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

The emerging role of carbohydrate antigen 125 in heart failure.
Authors: Santas E, Palau P, Bayés-Ge A, Núñez J PMID: 32125176 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - March 5, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Predictive biomarkers for molecular pathology in lung cancer.
Authors: Pisapia P, Pepe F, Troncone G, Malapelle U PMID: 32125183 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - March 5, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Elevated serum sortilin is related to carotid plaque concomitant with calcification.
Conclusion: Higher serum sortilin level was associated with carotid calcification and severe carotid plaque score. PMID: 32077308 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - February 22, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Exosomes-microRNAs interacted with gastric cancer and its microenvironment: a mini literature review.
Authors: Deng Z, Wu J, Xu S, Chen F, Zhang Z, Jin A, Wang J Abstract Exosomes have appeared as fundamental vehicle-modulated crosstalk among various cells in the tumor microenvironment. The systematic understanding of exosomes in gastric cancer (GC) enhances our comprehension about the tumor growth, metastasis, chemoresistance and diagnosis of cancers. The versatile functions of exosomes provide reasonable explanations about the propensity for GC metastasis. The selectively enriched components, especially some exosomal miRNAs, are potential noninvasive biomarkers for sensitive and specific GC diagnosis. Given the c...
Source: Future Medicine: Biomarkers in Medicine - February 19, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Discovery of candidate gene expression signatures in peripheral blood for the screening of cervical cancer.
Authors: Ma Q, Shao Y, Chen W, Quan C, Zhu Y, Xu X, Zhou Z, Wang S Abstract Aim: To investigate whether cervical cancer (CC) and cervical intraepithelial neoplasia (CIN) can be screened by analyzing gene expression profiling of peripheral blood. Methods: RNA-sequencing analysis of blood was performed on 11 CC patients, 21 CIN patients and 19 healthy controls (H). Fifty-nine genes were validated by quantitative real-time PCR using blood samples from 46 H, 83 CC and 32 CIN patients. Results: There were significant differences in the expression levels of six genes between CC and H, five genes between CIN and H and fou...
Source: Future Medicine: Biomarkers in Medicine - February 19, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research

Tears - more to them than meets the eye: why tears are a good source of biomarkers in Parkinson's disease.
Authors: Edman MC, Janga SR, Kakan SS, Okamoto CT, Freire D, Feigenbaum D, Lew M, Hamm-Alvarez SF Abstract Tears are a known source of biomarkers for both ocular and systemic diseases with particular advantages; specifically, the noninvasiveness of sample collection and a unique and increasingly better-defined protein composition. Here, we discuss our rationale for use of tears for discovery of biomarkers for Parkinson's disease (PD). These reasons include literature supporting changes in tear flow and composition in PD, and the interconnections between the ocular surface system and neurons affected in PD. We highl...
Source: Future Medicine: Biomarkers in Medicine - February 19, 2020 Category: Internal Medicine Tags: Biomark Med Source Type: research