Biomarkers detecting minimal residual disease in solid tumors: what do they mean in the clinical management of patients?
Authors: Murray NP PMID: 31631673 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 23, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Preoperative CD4+CD25+/CD4+ and tumor diameter predict prognosis in male patients with bladder cancer.
Conclusion: The combining predictor could be a significant predictor for advanced stage, OS and recurrence probability in male patients with BC. PMID: 31631674 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 23, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Systemic Immune-Inflammation Index predicting survival outcome in patients with classical Hodgkin lymphoma.
Conclusion: SII can be suggested as a novel independent and better prognostic factor for predicting overall survival and progression-free survival in HL. PMID: 31631675 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 23, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

PD-L1 an unavoidable biomarker in advanced triple-negative breast cancer.
Authors: Akiki M, Haddad FG, Kourie HR, Khaddage A, Smayra VT PMID: 31631684 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 23, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Prognostic performance of pancreatic stone protein in critically ill patients with sepsis.
Conclusion: The combination of PSP and lactate and PSP alone, on day 2, have a good performance for prognosis of 28-day mortality and could help to identify patients who may benefit most from tailored intensive care unit management. PMID: 31621373 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 18, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Prognostic utility of the combination of pretreatment monocyte-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with NMIBC after transurethral resection.
Authors: Wang Q, Huang T, Ji J, Wang H, Guo C, Sun X, Zheng K, Dong Z, Cao Y Abstract Aim: To investigate and validate predictive value of combination of pretreatment monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) for disease free survival (DFS) and overall survival (OS) in nonmuscle invasive bladder cancer after transurethral resection. Materials & methods: Total 358 patients enrolled were assigned into three (MLR-NLR 0, 1 and 2) groups per the cut-off values of MLR and NLR. Results: Kaplan-Meier curves showed MLR, NLR and their combination were statistically associated with DFS (p
Source: Future Medicine: Biomarkers in Medicine - October 18, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies.
Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies. PMID: 31621387 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 18, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Clinical research assessment by flow cytometry of biomarkers for infectious stratification in an Emergency Department.
Conclusion: This point-of-care technique could allow better management of patients in the ED. PMID: 31617736 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 17, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Evaluation of homocysteine in the diagnosis and prognosis of coronary slow flow syndrome.
Conclusion: Our results showed positive correlations of Hcy with CSFS and cardiac events. PMID: 31617742 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 17, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Comparison of monocyte with high density lipoprotein cholesterol ratio in dipper and nondipper hypertensive patients.
Authors: Selcuk M, Yildirim E, Saylik F Abstract Aim: We aimed to compare the monocyte to HDL-cholesterol ratio (MHR) of nondipper hypertension (NDHT) and dipper hypertension patients. Patients & methods: A total of 162 patients were included in the study. Patients were grouped as dipper and nondipper according to 24-h ambulatory blood pressure recordings. Results: The MHR was significantly higher in nondipper hypertension group compared with control (p
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Plasma S100A4 level and cardiovascular risk in patients with unstable angina pectoris.
Conclusion: Elevated S100A4 levels may be involved in the pathogenesis of UAP, and may be a marker predictive of post-treatment cardiovascular events. PMID: 31596125 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

The prognostic value of faciogenital dysplasias as biomarkers in head and neck squamous cell carcinoma.
Conclusion: Our findings suggest that the expression levels of FGD2 and FGD3 mRNAs in HNSC are associated with favorable prognosis and may be regarded as potential prognostic biomarkers. PMID: 31596126 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Serum DKK1 is correlated with γ peak of serum electrophoresis in multiple myeloma: a multicenter biomarker study.
Discussion: The observed correlation could be rooted in the positive feedback loop between MM cells and the mesenchymal stem cells. In view of these results, DKK1 could be deemed as diagnostic marker for MM. PMID: 31596134 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Prognostic significance of neutrophil-to-lymphocyte ratio in solid tumors: a note on methodological concerns.
Authors: Urabe M, Yamashita H, Seto Y PMID: 31599162 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Arterial stiffness is a vascular biomarker of chronic inflammation.
Authors: Zanoli L PMID: 31599163 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Biomarkers and their relationship to atrial fibrillation: mechanisms, prognosis and management.
Authors: Reiffel JA PMID: 31599164 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Novel cardiovascular risk biomarkers in metabolic syndrome.
Authors: Montecucco F, Liberale L, Carbone F PMID: 31599166 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

No obvious association exists between red blood cell distribution width and thyroid function.
Conclusion: The current study suggests that anisocytosis could be a contributing factor in thyroid dysfunction. PMID: 31599643 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Circulating pentraxin-3 levels in patients with systemic lupus erythematosus: a meta-analysis.
Conclusion: Circulating PTX3 levels are increased in SLE patients, and affected by age, ethnicity, SLEDAI and sample type. PMID: 31599644 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Expression levels of miR-21, miR-146b and miR-326 as potential biomarkers in Behcet's disease.
Conclusion: MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD. PMID: 31599663 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Higher maternal embryonic leucine zipper kinase mRNA expression level is a poor prognostic factor in non-small-cell lung carcinoma patients.
Authors: Zang X, Qian C, Ruan Y, Xie J, Luo T, Xu B, Jiang J Abstract Aim: To elucidate potential prognostic significance of MELK mRNA expression in non-small-cell lung carcinoma patients. Methods: A loop algorithm based on R software was used to select genes with the best prognostic value. Mantel-Haenszel method and functional enrichment analysis were used to perform this analysis. Results: MELK mRNA expression level in tumor tissue is significantly higher than that in normal/benign tissue (p
Source: Future Medicine: Biomarkers in Medicine - October 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Association of lymphocyte to monocyte ratio and risk of in-hospital mortality in patients with acute type A aortic dissection.
Authors: Lin Y, Peng Y, Chen Y, Li S, Huang X, Zhang H, Jiang F, Chen Q Abstract Aim: The aim of the study was to evaluate the relationship between lymphocyte to monocyte ratio (LMR) at admission and in-hospital mortality of patients with acute type A aortic dissection (AAAD). Patients & methods: We enrolled 536 patients with AAAD between June 2013 and December 2017. Patients were divided into two groups: the deceased group and the survival group. Results: In multivariable analysis, the association between LMR and in-hospital mortality was still significant. When the Q4 was set as the reference value, the odds ...
Source: Future Medicine: Biomarkers in Medicine - October 6, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

The relationship between CYP7A1 polymorphisms, coronary artery disease & serum lipid markers.
The relationship between CYP7A1 polymorphisms, coronary artery disease & serum lipid markers. Biomark Med. 2019 Oct 03;: Authors: Iwanicki T, Balcerzyk A, Niemiec P, Trautsolt W, Grzeszczak W, Ochalska-Tyka A, Krauze J, Nowak T, Żak I Abstract Polymorphic variants of the CYP7A1 gene can increase the risk of atherosclerosis-based coronary artery disease (CAD) and modify serum lipid markers. Method: We studied haplotype-tagging single nucleotide polymorphisms of CYP7A1 in the Caucasian population and if they are associated with CAD, its symptoms, and any of its risk factors. Results: We did not find...
Source: Future Medicine: Biomarkers in Medicine - October 4, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Evaluation of neutrophil-lymphocyte ratio in predicting bloodstream infection.
Authors: Qu J, Yuan HY, Huang Y, Qu Q, Ou-Yang ZB, Li GH, Zhu HH, Lu Q Abstract Aim: The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in bloodstream infection (BSI) deserves further investigation. Patients & methods: The NLR values were measured and compared in BSI patients and healthy controls. The receiver operating characteristic of NLR and cut-off values were measured in BSI patients and subgroups. Results: We have measured the NLR of study group with 2160 BSI patients and normal group with 2523 healthy controls, which was significantly high in study group (11.36 ± 21.38 vs 2.53 ± 0.86; p
Source: Future Medicine: Biomarkers in Medicine - October 4, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Biomarkers in diagnosing and treatment of acute heart failure.
Authors: Pourafkari L, Tajlil A, Nader ND Abstract Acute heart failure (AHF) is a complex disorder involving different pathophysiological pathways. In recent years, there is an increased focus on biomarkers that help with diagnosis, risk stratification and disease monitoring of AHF. Finding a reliable set of biomarkers not only improves morbidity and mortality but it can also potentially reveal the new targets of therapy. In this paper, we have reviewed the biomarkers found useful for the diagnosis as well as for risk stratification and prognostication in patients with AHF. We have discussed the established biomark...
Source: Future Medicine: Biomarkers in Medicine - October 4, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Variations in laboratory parameters in prechronic disease to determine disease occurrence at the molecular level.
Conclusion: The physiological or predisease state can be distinguished directly using the laboratory reference interval. PMID: 31580165 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - October 4, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Machine learning method for the management of acute kidney injury: more than just treating biomarkers individually.
Authors: Zhang Z PMID: 31559832 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 29, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Utilization of N-glycosylation profiles as risk stratification biomarkers for suboptimal health status and metabolic syndrome in a Ghanaian population.
Conclusion: Our results show that SHS is a significant, albeit modest, risk factor for MetS and N-glycan complexity was associated with MetS. PMID: 31559833 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 29, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

A novel nomogram for the differential diagnosis between advanced and early appendicitis in pediatric patients.
Conclusion: The nomogram is superior to the serum marker alone, and may hold promise in clinical application. PMID: 31559834 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 29, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome.
Conclusion: SDF-1 is an independent predictor of all-cause mortality and major adverse cardiovascular and cerebrovascular events in long-term follow-up of patients with ACS and adds prognostic information beyond traditional cardiovascular risks factors. PMID: 31559838 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 29, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Elastography during convex-probe (endobronchial ultrasound) for optimal biopsy sample and gene identification in non-small-cell lung cancer.
Authors: Zarogoulidis P, Kosmidis C, Fyntanidou V, Barmpas A, Koulouris C, Aidoni Z, Huang H, Bai C, Hohenforst-Schmidt W, Tsakiridis K, Sapalidis K PMID: 31559839 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 29, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

The transforming growth factor β superfamily as possible biomarkers of preeclampsia: a comprehensive review.
The transforming growth factor β superfamily as possible biomarkers of preeclampsia: a comprehensive review. Biomark Med. 2019 Sep 27;: Authors: Adu-Gyamfi EA, Lamptey J, Duan F, Wang YX, Ding YB Abstract The etiology of preeclampsia - an abnormal placentation-mediated disease - is not fully understood; and there are very few biomarkers with which to predict and diagnose it. Early prediction and diagnosis of this pathology can lead to a significant improvement in maternal and perinatal outcomes. Since members of the transforming growth factor β superfamily influence placentatio...
Source: Future Medicine: Biomarkers in Medicine - September 29, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Levels of oligomeric α-Synuclein in reflex tears distinguish Parkinson's disease patients from healthy controls.
Levels of oligomeric α-Synuclein in reflex tears distinguish Parkinson's disease patients from healthy controls. Biomark Med. 2019 Sep 25;: Authors: Hamm-Alvarez SF, Janga SR, Edman MC, Feigenbaum D, Freire D, Mack WJ, Okamoto CT, Lew MF Abstract Aim: Due to active engagement of sensory and afferent nerve fibers in reflex tearing which could be affected in Parkinson's disease (PD), we tested reflex tears as a source of potential PD biomarkers. Patients & methods: Reflex tears collected from 84 PD and 84 age- and sex-equivalent healthy controls (HC) were used to measure levels of oligomer...
Source: Future Medicine: Biomarkers in Medicine - September 27, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Perioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study.
Conclusion: Predicting post-surgery ARDS with perioperative proADM-change enables clinicians to intensify lung-protective interventions and individualized fluid therapy to minimize secondary injury. PMID: 31544475 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 24, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Polymorphisms of rs4787050 and rs8045980 are associated with lung cancer risk in northeast Chinese female nonsmokers.
Conclusion: The present study revealed that rs4787050 and rs8045980 in RBFOX1 may be meaningful as a novel biomarker for lung cancer susceptibility. PMID: 31512508 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 14, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

The significance of CO2 combining power in predicting prognosis of patients with stage II and III colorectal cancer.
Conclusion: The decreased CO2CP in CRC patients was associated with advanced clinical stage, and suggested that decreased CO2CP may predict the worse outcomes of disease-free survival in II/III stage CRC patients. PMID: 31497992 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 11, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Blood albumin as a prognostic factor among unselected medically treated inpatients.
Authors: Tojek K, Kowalczyk G, Czerniak B, Banaś W, Szukay B, Korzycka-Wilińska W, Banaszkiewicz Z, Budzyński J Abstract Aim: The aim of this study is to determine the prognostic value of blood albumin (BA) in an unselected population of inpatients. Materials & methods: We performed prospective analysis of the medical documentation of 7279 patients hospitalized between July 2014 and September 2017. Results: Individuals with BA ≥3.35 mg/dl had significantly lower risk of in-hospital death (odds ratio [OR]: 0.22; 95% CI: 0.19-0.27; p 
Source: Future Medicine: Biomarkers in Medicine - September 4, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Circulating antioxidant levels in systemic lupus erythematosus patients: a systematic review and meta-analysis.
Authors: Sam NB, Li BZ, Leng RX, Pan HF, Ye DQ Abstract Aim: To derive a precise estimation on plasma/serum level of SOD, GPx, CAT and GSH levels in systemic lupus erythematosus (SLE) patients. Methods: A total of 36 articles from electronic databases were finally included with 1120 SLE patients and 1024 healthy controls considered for antioxidant levels. Results: The levels of CAT and GSH were significantly lower, while SOD and GPx levels were slightly lower in patients with SLE compared with healthy controls. Subgroup analysis indicated that Arabs, ages ≥40 and SLE diseases activity index
Source: Future Medicine: Biomarkers in Medicine - September 4, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

ProANP and proBNP in plasma as biomarkers of heart failure.
Conclusion: Similar diagnostic performance of proANP and proBNP measurement for the diagnosis of heart failure was identified. Consequently, mid-regional proANP can be used when considering a diagnosis of heart failure. PMID: 31468978 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 1, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Detection of early breast cancer beyond mammographic screening: a promising biomarker panel.
Conclusion: This biomarker panel may improve early detection of BC and influence the assessment of breast imaging. It might be useful for a risk-adapted cancer surveillance or primary prevention program by a more precise determination of an individualized BC risk. PMID: 31468986 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 1, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Novel biomarkers may aid the decision for CT scan in emergency setting in mild head trauma.
Authors: Alexiou GA, Lianos GD, Sotiropoulos A, Voulgaris S PMID: 31468996 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - September 1, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Liquid biopsy: a holy grail for cancer detection.
Authors: Sorbara L, Srivastava S PMID: 31464153 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - August 31, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

The prevalence of EML4-ALK variants in patients with non-small-cell lung cancer: a systematic review and meta-analysis.
Conclusion: This present study provides the exact prevalence of EML4-ALK rearrangement in different variants for NSCLC patients with ALK positive. PMID: 31432686 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - August 22, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Usefulness of the whole blood viscosity to predict stent thrombosis in ST-elevation myocardial infarction.
Conclusion: Being an easily accessible and costless parameter, WBV seems to be an emerging predictor of ST in patients with STEMI. PMID: 31429589 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - August 21, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Diagnostic value of NKG2D promoter methylation in hepatitis B virus-associated hepatocellular carcinoma.
Conclusion: NKG2D promoter methylation can be used as a noninvasive marker for detecting HCC. PMID: 31411040 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - August 15, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Sickle cell disease nephropathy: an update on risk factors and potential biomarkers in pediatric patients.
Authors: Belisário AR, da Silva AA, Silva CV, de Souza LM, Wakabayashi EA, Araújo SA, Simoes-E-Silva AC Abstract One of the major chronic complications of sickle cell disease (SCD) is sickle cell nephropathy. The aim of this review is to discuss the pathophysiology, natural history, clinical manifestations, risk factors, biomarkers and therapeutic approaches for sickle cell nephropathy, focusing on studies with pediatric patients. The earliest manifestation of renal disease is an increase in the glomerular filtration rate. A finding that may also be observed in early childhood is microalbuminuria. Nep...
Source: Future Medicine: Biomarkers in Medicine - August 10, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

A novel prognostic marker based on risk stratification with prognostic nutritional index and age for nasopharyngeal carcinoma patients who received neoadjuvant chemotherapy.
Authors: He Q, Huang Y, Wan G, Feng M, Zeng H, Liu M, Luo H, Yang Y, Song X, Zhang L, Lang J Abstract Aim: To evaluate the prognostic value of pretreatment prognostic nutritional index (PNI) in nasopharyngeal carcinoma (NPC) patients treated with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy. Materials & methods: We conducted a retrospective study on prognostic value of PNI in NPC patients. A new prognostic marker was explored based on risk stratification with PNI and age. Results: PNI and age were two independent prognostic factors for overall survival (OS) and progression free su...
Source: Future Medicine: Biomarkers in Medicine - August 8, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Blood circulating miRNAs as biomarkers of Alzheimer's disease: a systematic review and meta-analysis.
Conclusion: This meta-analysis showed that miRNAs may be a promising biomarkers for AD. PMID: 31385521 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - August 8, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Biomarker targeting of colorectal cancer stem cells.
Authors: Caparosa EM, Stem J, Snook AE, Waldman SA PMID: 31385523 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - August 8, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Probabilistic medicine: a pre-emptive approach is needed for cancer therapeutic risk mitigation.
Authors: Hicks JK, McLeod HL PMID: 31385527 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - August 8, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research