The relationship between levels of tumor necrosis factor-alpha, interleukin-6, and C-reactive protein in the serum of elderly and acute myocardial infarction
This study aimed to explore the relationship between the serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and hypersensitive C-reactive protein (hs-CRP) and the prognosis of acute myocardial infarction (AMI) patients after percutaneous coronary intervention (PCI) treatment. A total of 118 early-onset AMI patients who successfully received PCI (in the PCI group, blood samples were collected before PCI, 12, 24, 48 h after PCI, and 90 d follow-up period) and 52 AMI patients who received only cardioangiography (CAG) (in the CAG group, blood samples were collected before CAG, 12, 24, 48 h after CAG, and 9...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Jinlong Miao Tao Du Source Type: research

The relationship between levels of tumor necrosis factor-alpha, interleukin-6, and C-reactive protein in the serum of elderly and acute myocardial infarction
This study aimed to explore the relationship between the serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and hypersensitive C-reactive protein (hs-CRP) and the prognosis of acute myocardial infarction (AMI) patients after percutaneous coronary intervention (PCI) treatment. A total of 118 early-onset AMI patients who successfully received PCI (in the PCI group, blood samples were collected before PCI, 12, 24, 48 h after PCI, and 90 d follow-up period) and 52 AMI patients who received only cardioangiography (CAG) (in the CAG group, blood samples were collected before CAG, 12, 24, 48 h after CAG, and 9...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Jinlong Miao Tao Du Source Type: research

Drug-coated balloon in the treatment of coronary artery de-novo large lesions angiography
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):196-201. doi: 10.14715/cmb/2024.70.4.31.ABSTRACTThe superiority of drug-coated balloon (DCB) in treating small vessels, branching lesions, and high-risk bleeding lesions in coronary heart disease patients has been confirmed. However, its safety and efficacy in large vessels are still unclear. We aimed to investigate whether the efficacy of DCB in large vessels is not inferior to that of drug-eluting stent (DES). From November 2019 to April 2022, a total of 88 patients in our hospital who underwent coronary angiography for the first time and decided to receive DCB or DES tre...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Xingyou Cai Xin Hong Yuli Wang Yafei Li Guidong Xu Source Type: research

The Current State of Hybrid Coronary Revascularization
Ann Thorac Surg. 2024 Apr 25:S0003-4975(24)00299-6. doi: 10.1016/j.athoracsur.2024.04.010. Online ahead of print.ABSTRACTHybrid coronary revascularization (HCR) combines a minimally invasive surgical approach with percutaneous coronary intervention (PCI) for the treatment of multi-vessel coronary artery disease. Despite decades of use, widespread acceptance has been limited. In this review, we conduct a comparative assessment of HCR in relation to traditional coronary artery bypass graft surgery and multi-vessel PCI. While large scale randomized data is still lacking, numerous studies have demonstrated that HCR may offer b...
Source: The Annals of Thoracic Surgery - April 27, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Robin Willard Joshua Scheinerman Stevan Pupovac Nirav C Patel Source Type: research

The Current State of Hybrid Coronary Revascularization
Ann Thorac Surg. 2024 Apr 25:S0003-4975(24)00299-6. doi: 10.1016/j.athoracsur.2024.04.010. Online ahead of print.ABSTRACTHybrid coronary revascularization (HCR) combines a minimally invasive surgical approach with percutaneous coronary intervention (PCI) for the treatment of multi-vessel coronary artery disease. Despite decades of use, widespread acceptance has been limited. In this review, we conduct a comparative assessment of HCR in relation to traditional coronary artery bypass graft surgery and multi-vessel PCI. While large scale randomized data is still lacking, numerous studies have demonstrated that HCR may offer b...
Source: The Annals of Thoracic Surgery - April 27, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Robin Willard Joshua Scheinerman Stevan Pupovac Nirav C Patel Source Type: research

Effectiveness of late coronary angioplasty in restoring sinus rhythm in inferior wall myocardial infarction with complete AV block
Coronary angiogram done with temporary pacemaker support showing a proximally occluded right coronary artery. AbstractAn elderly gentleman presenting late with inferior wall myocardial infarction and complete heart block underwent revascularization of an occluded proximal right coronary artery more than 4  days after the onset of symptoms and recovered sinus rhythm within 48 h of the procedure. There are no clear guidelines for time to percutaneous coronary intervention (PCI) in late-presenting myocardial infarction with complete atrioventricular blocks (CAVB), and studies looking at outcomes of primary PCI in this sit...
Source: Clinical Case Reports - April 27, 2024 Category: General Medicine Authors: Avitso Liegise, Lanu Naro Tags: CASE REPORT Source Type: research

Improvement of coronary stent visualization using ultra-high-resolution photon-counting detector CT
ConclusionUHR CCTA by PCD-CT leads to significantly improved visualization and diagnostic performance of coronary stents, and Bv72 is the optimal reconstruction kernel showing the stent struts and in-stent lumen.Clinical relevance statementThe significantly improved visualization of coronary stents using ultra-high resolution CCTA could increase the diagnostic accuracy for in-stent restenosis and avoid unnecessary invasive quantitative coronary angiography, thus changing the clinical management for patients after percutaneous coronary intervention.Key PointsCoronary stent imaging is challenging with energy-integrating dete...
Source: European Radiology - April 27, 2024 Category: Radiology Source Type: research

Revascularizing Multivessel Coronary Artery Disease in Acute Coronary Syndromes: Choices and Questions
Acute coronary syndrome (ACS) is a leading cause of hospital admissions and mortality worldwide1. Revascularization of coronary artery disease (CAD) has been shown to improve cardiovascular outcomes including mortality in this patient population2. When a clear, single vessel culprit coronary artery lesion is identified on invasive coronary angiography, then the revascularization decision is straightforward with percutaneous coronary intervention (PCI) as the best option3. However, approximately 50% of patients presenting with ACS are found to have multivessel CAD, and then the decision on which revascularization strategy t...
Source: The American Journal of Cardiology - April 27, 2024 Category: Cardiology Authors: Rafic F. Berbarie Tags: Editorial Source Type: research

Characteristics of Patients Undergoing High-Risk Percutaneous Coronary Intervention in Contemporary United States Practice
There is no universally accepted definition of high-risk percutaneous coronary intervention (HRPCI), nor is there consensus regarding when to use mechanical circulatory support (MCS) during HRPCI. Expert consensus on HRPCI have suggested considering the presence of three distinct entities in the decision to use MCS: complexity of coronary anatomy/ lesion characteristics, patient comorbidities, and adverse hemodynamics1. Although the use of MCS during HRPCI has increased significantly over the past decade (27-fold increase in annual number from 2008 to 2018)2, little is known regarding the detailed characteristics of these ...
Source: The American Journal of Cardiology - April 26, 2024 Category: Cardiology Authors: Aditya S. Bharadwaj, Alexander G. Truesdell, Alejandro Lemor, Julia B. Thompson, Arsalan Abu-Much, Yiran Zhang, Michael J. Schonning, David J. Cohen, Alexandra J. Lansky, William W. O'Neill Tags: Brief report Source Type: research

Real-World Experience and Outcomes with Percutaneous Coronary Intervention for Protected versus Unprotected Left Main Coronary Artery Disease: Insights from the VA CART Program
Practice patterns and outcomes of protected left main (PLM) and unprotected left main (ULM) percutaneous coronary intervention (PCI) are not well defined in contemporary US clinical practice. Data collected from all Veteran Affairs (VA) catheterization laboratories participating in the Clinical Assessment Reporting and Tracking Program between 2009 and 2019. The analysis included 4,351 patients undergoing left main PCI, of which 1,306 pairs of PLM and ULM PCI were included in a propensity matched cohort. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 25, 2024 Category: Cardiology Authors: Pedro Engel Gonzalez, Annika Hebbe, Yasin Hussain, Rohan Khera, Subhash Banerjee, Mary E Plomondon, Stephen W. Waldo, Steven E. Pfau, Jeptha P. Curtis, Samit M. Shah Source Type: research

Percutaneous coronary intervention versus medical therapy in stable angina: a matched cohort study
Conclusions PCI plus OMT was associated with higher rate of primary endpoint of MI, stroke, cardiac death as compared with OMT alone in patients with pure stable angina at 9.3-year follow-up in large population. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Jo, S.-H., Kim, H., Kim, H.-J., Lee, M.-H., Seo, W.-W., Kim, M., Kim, H.-L. Tags: Coronary artery disease Source Type: research

Impact of periprocedural myocardial injury on long-term outcomes after percutaneous coronary intervention requiring atherectomy
Percutaneous coronary intervention (PCI) is the most frequent type of coronary revascularization, and is performed with the aim of relieving anginal symptoms, reducing the need for urgent revascularization, and lowering the risk of spontaneous myocardial infarction (1,2). Conversely, patients undergoing PCI are at risk of procedure-related myocardial injury, which may offset these benefits or even worsen the clinical course. Myocardial injury following PCI is assessed by the rise in cardiac biomarkers, commonly cardiac troponin. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 25, 2024 Category: Cardiology Authors: Hiroki Emori, Yasutsugu Shiono, Nehiro Kuriyama, Yasuhiro Honda, Kosuke Kadooka, Takeaki Kudo, Kenji Ogata, Toshiyuki Kimura, Kensaku Nishihira, Atsushi Tanaka, Yoshisato Shibata Source Type: research

Percutaneous intravascular micro-axial blood pump: current state and perspective from engineering view
AbstractThe utilization of a minimally invasively placed catheter-mounted intravascular micro-axial flow blood pump (IMFBP) is increasing in the population with advanced heart failure. The current development of IMFBPs dates back around the 1990s, namely the Hemopump with a wire-drive system and the Valvopump with a direct-drive system. The wire-drive IMFBPs can use a brushless motor in an external console unit to transmit rotational force through the drive wire rotating the impeller inside the body. The direct-drive IMFBPs require an ultra-miniature and high-power brushless motor. Additionally, the direct-drive system nec...
Source: Journal of Artificial Organs - April 25, 2024 Category: Transplant Surgery Source Type: research

Inflammation modifies the platelet reactivity among thrombocytopenia patients undergoing percutaneous coronary intervention
Platelets. 2024 Dec;35(1):2327835. doi: 10.1080/09537104.2024.2327835. Epub 2024 Apr 24.ABSTRACTPercutaneous coronary intervention (PCI) patients combined with thrombocytopenia (TP) are usually considered to be at low ischemic risk, receiving less proper antiplatelet therapy. However, recent studies reported a paradoxical phenomenon that PCI patients with TP were prone to experience thrombotic events, while the mechanisms and future treatment remain unclear. We aim to investigate whether inflammation modifies platelet reactivity among these patients. Consecutive 10 724 patients undergoing PCI in Fuwai Hospital were enrolle...
Source: Platelets - April 24, 2024 Category: Hematology Authors: Kailun Yan Jiawen Li Yulong Li Pei Zhu Xiaofang Tang Deshan Yuan Yuejin Yang Runlin Gao Jinqing Yuan Xueyan Zhao Source Type: research

The Association of CHADS-P2A2RC Risk Score With Clinical Outcomes in Patients Taking P2Y12 Inhibitor Monotherapy After 3 Months of Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention
CONCLUSIONS: The CHADS-P2A2RC risk score is valuable in discriminating high-ischemic-risk patients. Even in such patients with a high risk of ischemic events, P2Y12 inhibitor monotherapy was associated with a lower incidence of bleeding without increased risk of ischemic events compared with prolonged DAPT.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02079194.PMID:38654565 | PMC:PMC11040264 | DOI:10.4070/kcj.2023.0268 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Pil Sang Song Seok-Woo Seong Ji-Yeon Kim Soo Yeon An Mi Joo Kim Kye Taek Ahn Seon-Ah Jin Jin-Ok Jeong Jeong Hoon Yang Joo-Yong Hahn Hyeon-Cheol Gwon Woo Jin Jang Hyuck Jun Yoon Jang-Whan Bae Woong Gil Choi Young Bin Song Source Type: research