Pemphigoid of the pulmonary system
Ann Dermatol Venereol. 2024 Mar 27;151(2):103253. doi: 10.1016/j.annder.2024.103253. Online ahead of print.NO ABSTRACTPMID:38547598 | DOI:10.1016/j.annder.2024.103253 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - March 28, 2024 Category: Dermatology Authors: A R Ahmed M Kalesinskas Source Type: research
Sensitive and specific assay for the serological diagnosis of anti-p200 pemphigoid based on the recombinant laminin β4 subunit
Br J Dermatol. 2024 Mar 28:ljae136. doi: 10.1093/bjd/ljae136. Online ahead of print.NO ABSTRACTPMID:38544457 | DOI:10.1093/bjd/ljae136 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 28, 2024 Category: Dermatology Authors: Stephanie Goletz Christian Probst Lars Komorowski Christiane Radzimski Swantje Mindorf Maike M Holtsche Manuela Pigors Nina van Beek Detlef Zillikens Wolfgang Schlumberger Enno Schmidt Source Type: research
Pemphigoid of the pulmonary system
Ann Dermatol Venereol. 2024 Mar 27;151(2):103253. doi: 10.1016/j.annder.2024.103253. Online ahead of print.NO ABSTRACTPMID:38547598 | DOI:10.1016/j.annder.2024.103253 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 28, 2024 Category: Dermatology Authors: A R Ahmed M Kalesinskas Source Type: research
Pemphigoid of the pulmonary system
Ann Dermatol Venereol. 2024 Mar 27;151(2):103253. doi: 10.1016/j.annder.2024.103253. Online ahead of print.NO ABSTRACTPMID:38547598 | DOI:10.1016/j.annder.2024.103253 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - March 28, 2024 Category: Dermatology Authors: A R Ahmed M Kalesinskas Source Type: research
Sensitive and specific assay for the serological diagnosis of anti-p200 pemphigoid based on the recombinant laminin β4 subunit
Br J Dermatol. 2024 Mar 28:ljae136. doi: 10.1093/bjd/ljae136. Online ahead of print.NO ABSTRACTPMID:38544457 | DOI:10.1093/bjd/ljae136 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 28, 2024 Category: Dermatology Authors: Stephanie Goletz Christian Probst Lars Komorowski Christiane Radzimski Swantje Mindorf Maike M Holtsche Manuela Pigors Nina van Beek Detlef Zillikens Wolfgang Schlumberger Enno Schmidt Source Type: research
Sensitive and specific assay for the serological diagnosis of anti-p200 pemphigoid based on the recombinant laminin β4 subunit
Br J Dermatol. 2024 Mar 28:ljae136. doi: 10.1093/bjd/ljae136. Online ahead of print.NO ABSTRACTPMID:38544457 | DOI:10.1093/bjd/ljae136 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 28, 2024 Category: Dermatology Authors: Stephanie Goletz Christian Probst Lars Komorowski Christiane Radzimski Swantje Mindorf Maike M Holtsche Manuela Pigors Nina van Beek Detlef Zillikens Wolfgang Schlumberger Enno Schmidt Source Type: research
Single-cell profiling unveils the inflammatory heterogeneity within cutaneous lesions of bullous pemphigoid
Bullous pemphigoid (BP) is a subepidermal blistering skin disease with a complex pathogenesis involving various immune cells. However, the transcriptional features of these cells remain poorly defined. Here, we construct a comprehensive and single-cell resolution atlas of various immune cells within BP skin lesions via integrative single-cell analysis, flow cytometry and multiplex immunohistochemistry. We observed prominent expansion and transcriptional changes in mast cells, macrophages, basophils, and neutrophils within BP lesions. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 25, 2024 Category: Dermatology Authors: Yue Ruan, Chuqiao Xu, Tianyu Zhang, Lin Zhu, Hailun Wang, Jingying Wang, Haiqin Zhu, Chuanxin Huang, Meng Pan Tags: Original Article Source Type: research
Anti-BP230 IgE autoantibodies in bullous pemphigoid intraindividually correlate with disease activity
Bullous pemphigoid (BP), the most common subepidermal autoimmune blistering disease, is classically defined by the presence of IgG autoantibodies directed against the hemidesmosomal proteins BP180 (type XVII collagen) and BP230 and the predominance of skin lesions. Several studies have addressed the role of anti-BP180 IgE in patients and experimental models, while data on anti-BP230 IgE are scarce. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 22, 2024 Category: Dermatology Authors: Shirin Emtenani, Beke E. Linnemann, Andreas Recke, Anabelle von Georg, Stephanie Goltez, Enno Schmidt, Nina van Beek Source Type: research
Regenerative potential of platelet concentrates in chronic oral mucosal lesions
J Oral Biol Craniofac Res. 2024 Mar-Apr;14(2):216-221. doi: 10.1016/j.jobcr.2024.02.007. Epub 2024 Mar 6.ABSTRACTChronic oral mucosal diseases (COMDs) represent a significant challenge for clinicians and patients. They are commonly associated with chronic pain and negative effects on healing and patient's quality of life. Regenerative medicine including the use of biological autologous blood-derived substances (e.g., platelet concentrates [PCs]), has been reported to improve healing and reduce pain in orthopedic and maxillofacial surgeries as well as chronic oral mucosal diseases. In this review, we aim to describe the dif...
Source: Cell Research - March 15, 2024 Category: Cytology Authors: Abdel-Hameed Hijazi Faez Saleh Al-Hamed Faleh Tamimi Sadeq A Al-Maweri Nader Hamdan David J Psutka Peter Ta Hagen Klieb Source Type: research
Fiberoptic endoscopic assessment of dysphagia in a patient with cutaneous and oropharyngeal blisters
This case study provides fiberoptic endoscopic evidence of pharyngeal dysphagia in a patient with bullous pemphigoid. Key Clinical MessageDysphagia resulting from bulbous pemphigoid is a rare but significant manifestation. A 77-year-old with bullous pemphigoid with no neurological history presented with severe oropharyngeal dysphagia, attributable to underlying blistering and edema, as documented on a fiberoptic endoscopic swallow examination. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 14, 2024 Category: General Medicine Authors: Allison Hughes Bartholow Tags: CASE REPORT Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Yasutoshi Hida Riho Kageji Hirofumi Bekku Norito Ishii Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Yasutoshi Hida Riho Kageji Hirofumi Bekku Norito Ishii Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
