Single-cell profiling unveils the inflammatory heterogeneity within cutaneous lesions of bullous pemphigoid

Bullous pemphigoid (BP) is a subepidermal blistering skin disease with a complex pathogenesis involving various immune cells. However, the transcriptional features of these cells remain poorly defined. Here, we construct a comprehensive and single-cell resolution atlas of various immune cells within BP skin lesions via integrative single-cell analysis, flow cytometry and multiplex immunohistochemistry. We observed prominent expansion and transcriptional changes in mast cells, macrophages, basophils, and neutrophils within BP lesions.

Source: Journal of Investigative Dermatology - March 25, 2024 Category: Dermatology Authors: Yue Ruan, Chuqiao Xu, Tianyu Zhang, Lin Zhu, Hailun Wang, Jingying Wang, Haiqin Zhu, Chuanxin Huang, Meng Pan Tags: Original Article Source Type: research