Accurate diagnosis of bullous pemphigoid requires multiple health care visits
DiscussionOne diagnostic code of L12.0 is not enough to recognize BP in a large epidemiological data set; including only L12.0 registered in dermatology units and excluding cases with <3 L12.0 record entries markedly increases the PPV of BP diagnosis. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - November 27, 2023 Category: Allergy & Immunology Source Type: research
Rituximab and Omalizumab Combination Therapy for Bullous Pemphigoid
This research letter reports on a case series of 10 patients with bullous pemphigoid treated with rituximab combined with omalizumab. (Source: JAMA Dermatology)
Source: JAMA Dermatology - November 22, 2023 Category: Dermatology Source Type: research
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations
AbstractThough more common earlier in life, increasing attention is being focused on the development of cutaneous lupus erythematosus (CLE) in patients with advancing age. Studies show that CLE is more common in older populations than previously thought, and all CLE subtypes are possible in this group. Just like patients in the third or fourth decade of life, CLE may appear alongside or independent of systemic lupus erythematosus. Older populations manifesting CLE for the first time seem to have a lower risk of progression to systemic disease than younger peers, and are more commonly White. CLE must be carefully distinguis...
Source: Drugs and Aging - November 22, 2023 Category: Geriatrics Source Type: research
Laminin β4 is a constituent of the cutaneous basement membrane zone and additional autoantigen of anti-p200 pemphigoid
Anti-p200 pemphigoid is a subepidermal autoimmune blistering disease (AIBD) characterized by autoantibodies against a 200 kDa protein. Laminin γ1 has been described as target antigen in 70-90% of patients. No diagnostic assay is widely available for anti-p200 pemphigoid, which might be due to the unclear pathogenic relevance of anti-laminin γ1 autoantibodies. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 20, 2023 Category: Dermatology Authors: Stephanie Goletz, Manuela Pigors, Tina Rastegar Lari, Christoph M. Hammers, Yao Wang, Shirin Emtenani, Monique Aumailley, Maike M. Holtsche, Felix H. Stang, Imke Weyers, Inke R. K önig, Cristina Has, Christiane Radzimski, Lars Komorowski, Detlef Zilliken Source Type: research
Violaceous Nodules on the Right Lower Leg
An patient with a history of bullous pemphigoid treated with oral prednisolone presented with multiple round, dark brown to violaceous-colored firm nodules on the right leg and 2 nodular masses with hemorrhagic crusts on the right foot. Complete blood cell count and creatinine and liver function test results were normal, and results of HIV antibody testing were negative. What is the diagnosis and what would you do next? (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - November 20, 2023 Category: General Medicine Source Type: research
Targeting interleukin (IL)-4/IL-13 in immune checkpoint inhibitor-induced bullous pemphigoid: a cautionary note on the beneficial effect of T helper 2 immunity in melanoma and immunotherapy: reply from the authors
Br J Dermatol. 2023 Nov 8:ljad342. doi: 10.1093/bjd/ljad342. Online ahead of print.NO ABSTRACTPMID:37947404 | DOI:10.1093/bjd/ljad342 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 10, 2023 Category: Dermatology Authors: William D Shipman Katelyn Singh Jeffery M Cohen Jonathan Leventhal William Damsky Mary M Tomayko Source Type: research
The gut microbiome in bullous pemphigoid: implications of the gut-skin axis for disease susceptibility
Bullous pemphigoid (BP) is an autoimmune blistering disease that primarily affects the elderly. An altered skin microbiota in BP was recently revealed. Accumulating evidence points toward a link between the gut microbiota and skin diseases; however, the gut microbiota composition of BP patients remains largely underexplored, with only one pilot study to date, with a very limited sample size and no functional profiling of gut microbiota. To thoroughly investigate the composition and function of the gut microbiota in BP patients, and explore possible links between skin conditions and gut microbiota, we here investigated the ...
Source: Frontiers in Immunology - November 10, 2023 Category: Allergy & Immunology Source Type: research
Omalizumab Therapy of Bullous Pemphigoid
Br J Dermatol. 2023 Nov 6:ljad432. doi: 10.1093/bjd/ljad432. Online ahead of print.NO ABSTRACTPMID:37939788 | DOI:10.1093/bjd/ljad432 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2023 Category: Dermatology Authors: Janet A Fairley Kelly A N Messingham Source Type: research
Omalizumab Therapy of Bullous Pemphigoid
Br J Dermatol. 2023 Nov 6:ljad432. doi: 10.1093/bjd/ljad432. Online ahead of print.NO ABSTRACTPMID:37939788 | DOI:10.1093/bjd/ljad432 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2023 Category: Dermatology Authors: Janet A Fairley Kelly A N Messingham Source Type: research
