Pemphigus and pemphigoid are associated with Alzheimer ’s disease in older adults: evidence from the US Nationwide inpatient sample 2016–2018
Pemphigus and pemphigoid are rare autoimmune skin disorders caused by autoantibodies against structural proteins and characterized by blistering of the skin and/or mucous membranes. Associations have been note... (Source: BMC Geriatrics)
Source: BMC Geriatrics - December 19, 2023 Category: Geriatrics Authors: Zhen Xie, Yang Gao, Lidi Tian, Yang Jiang, Hao Zhang and Yang Su Tags: Research Source Type: research
Study of cytokine-induced immunity in bullous pemphigoid: recent developments
Ann Med. 2023;55(2):2280991. doi: 10.1080/07853890.2023.2280991. Epub 2023 Dec 18.ABSTRACTBullous pemphigoid (BP) is an organ-specific disease. Its pathogenesis has not been clearly studied yet; However, studies in recent years have shown that its pathogenesis is related to T helper cells. The pathogenesis of BP is mainly related to Th2 and Th17-related cytokines. IL-4, IL-5 and IL-13 cause eosinophil recruitment, promote antibody production, trigger pruritus and promote blister formation and other symptoms. IL-17 and IL-23 promote the production of matrix metalloproteinase-9 (MMP-9) by related cells, which causes dermo-ep...
Source: Annals of Medicine - December 18, 2023 Category: Internal Medicine Authors: Ruiting Huang Lingyu Hu Fuqiong Jiang Source Type: research
Retrospective Analysis of 397 Dermatoses Inpatients Associated with Blood Eosinophilia
CONCLUSION: We summarize the clinical rules of dermatoses associated with blood eosinophilia, hoping to facilitate the diagnosis and treatment for patients.PMID:38077918 | PMC:PMC10700038 | DOI:10.2147/CCID.S429183 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - December 11, 2023 Category: Dermatology Authors: Ying Zhao Jing Tian Cuie Gao Lu Liu Linxin Pan Zhiqiang Song Source Type: research
A case of bullous pemphigoid and renal disease after dipeptidyl peptidase 4 inhibitor administration
AbstractA 62-year-old man with type 2 diabetes was admitted because of a decrease in estimated glomerular filtration rate from 72 to 17.5 mL/min/1.73 m2 in 10 years and development of widespread bullous skin lesions. His hemoglobin A1c level had been maintained at 6.0–7.0% for 10 years with a dipeptidyl peptidase (DPP)-4 inhibitor. Skin biopsy showed typical bullous pemphigoid, and kidney biopsy showed tubulointerstitial nephritis with eosinophilic i nfiltration and glomerular endothelial cell proliferation. After discontinuing the DPP-4 inhibitor, skin lesions improved, and renal decline slowed. This case indicate...
Source: CEN Case Reports - December 6, 2023 Category: Urology & Nephrology Source Type: research
Monocyte populations are involved in the pathogenesis of experimental epidermolysis bullosa acquisita
Monocytes play a significant role in the pathogenesis of most inflammatory diseases, including autoimmune diseases. Herein, different subpopulations of monocytes often play differential, partially antagonistic roles, in the regulation of tissue populations. Pemphigoid diseases constitute a group of autoimmune blistering skin diseases featuring a marked infiltration of the dermis with immune cells, including monocytes. The monocyte subsets infiltrating the skin, however, have largely remained elusive. Monocyte adhesion and recruitment into the inflamed tissues are regulated by chemokine receptors, most prominently by CCR2 a...
Source: Frontiers in Immunology - December 5, 2023 Category: Allergy & Immunology Source Type: research
HSD96 Trends in the Therapeutic Management of Bullous Pemphigoid in the Real-World Setting
The objective of this research was to characterize real-world treatment patterns among bullous pemphigoid patients in diverse healthcare delivery settings in the United States (US). (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: A. Althoff, L. Rasouliyan, V. Kumar, S. Long, A. Mummert, S. Chang Source Type: research
CO69 Evidence Gap Analysis of the Burden of Illness and Treatment of Bullous Pemphigoid
To identify evidence gaps in the literature on the burden of illness and treatment of bullous pemphigoid (BP) to support the launch of efgartigimod to treat this rare disease. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: L. Gildea, K. Copley-Merriman, C. Arvin-Berod, K. Vande Walle, P. Verheesen, I. Stoykov Source Type: research
Gliptin-induced bullous pemphigoid
CONCLUSION: The proper management of autoimmune bullous skin disorders in elderly patients includes a scrupulous assessment of plausible drug triggers. Systemic corticosteroids for treating severe cases of DIBP can worsen concomitant diseases which often necessitates multidisciplinary care.PMID:38032147 | DOI:10.5414/CP204478 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - November 30, 2023 Category: Drugs & Pharmacology Authors: Maria Ganeva Tanya Gancheva Karen Manuelyan Evgenya Hristakieva Source Type: research
Gliptin-induced bullous pemphigoid
CONCLUSION: The proper management of autoimmune bullous skin disorders in elderly patients includes a scrupulous assessment of plausible drug triggers. Systemic corticosteroids for treating severe cases of DIBP can worsen concomitant diseases which often necessitates multidisciplinary care.PMID:38032147 | DOI:10.5414/CP204478 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 30, 2023 Category: Drugs & Pharmacology Authors: Maria Ganeva Tanya Gancheva Karen Manuelyan Evgenya Hristakieva Source Type: research
Gliptin-induced bullous pemphigoid
CONCLUSION: The proper management of autoimmune bullous skin disorders in elderly patients includes a scrupulous assessment of plausible drug triggers. Systemic corticosteroids for treating severe cases of DIBP can worsen concomitant diseases which often necessitates multidisciplinary care.PMID:38032147 | DOI:10.5414/CP204478 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - November 30, 2023 Category: Drugs & Pharmacology Authors: Maria Ganeva Tanya Gancheva Karen Manuelyan Evgenya Hristakieva Source Type: research
Gliptin-induced bullous pemphigoid
CONCLUSION: The proper management of autoimmune bullous skin disorders in elderly patients includes a scrupulous assessment of plausible drug triggers. Systemic corticosteroids for treating severe cases of DIBP can worsen concomitant diseases which often necessitates multidisciplinary care.PMID:38032147 | DOI:10.5414/CP204478 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 30, 2023 Category: Drugs & Pharmacology Authors: Maria Ganeva Tanya Gancheva Karen Manuelyan Evgenya Hristakieva Source Type: research
