Laminin β4 is a constituent of the cutaneous basement membrane zone and additional autoantigen of anti-p200 pemphigoid

Anti-p200 pemphigoid is a subepidermal autoimmune blistering disease (AIBD) characterized by autoantibodies against a 200 kDa protein. Laminin γ1 has been described as target antigen in 70-90% of patients. No diagnostic assay is widely available for anti-p200 pemphigoid, which might be due to the unclear pathogenic relevance of anti-laminin γ1 autoantibodies.

Source: Journal of the American Academy of Dermatology - November 20, 2023 Category: Dermatology Authors: Stephanie Goletz, Manuela Pigors, Tina Rastegar Lari, Christoph M. Hammers, Yao Wang, Shirin Emtenani, Monique Aumailley, Maike M. Holtsche, Felix H. Stang, Imke Weyers, Inke R. K önig, Cristina Has, Christiane Radzimski, Lars Komorowski, Detlef Zilliken Source Type: research