Sustained inflation improves initial lung aeration in newborn rabbits with a diaphragmatic hernia
CONCLUSION: While an SI improved the rate and uniformity of lung aeration in both DH and control kittens, greater consideration of the post-SI ventilation strategy is required to sustain this benefit.IMPACT: Compared to intermittent positive pressure ventilation (IPPV), an initial sustained inflation (SI) increased the rate and uniformity of lung aeration after birth. However, this initial benefit is rapidly lost following the switch to IPPV. The optimal approach for ventilating CDH infants at birth is unknown. While an SI improves lung aeration in immature lungs, its effect on the hypoplastic lung is unknown. This study h...
Source: Pediatric Research - November 11, 2023 Category: Pediatrics Authors: Lauren Hadley Andreas W Flemmer Marcus J Kitchen Michelle K Croughan Kelly J Crossley Katie L Lee Erin McGillick Megan J Wallace James T Pearson Philip DeKoninck Ryan Hodges Arjan B Te Pas Stuart B Hooper Marta Thio Source Type: research
Sustained inflation improves initial lung aeration in newborn rabbits with a diaphragmatic hernia
CONCLUSION: While an SI improved the rate and uniformity of lung aeration in both DH and control kittens, greater consideration of the post-SI ventilation strategy is required to sustain this benefit.IMPACT: Compared to intermittent positive pressure ventilation (IPPV), an initial sustained inflation (SI) increased the rate and uniformity of lung aeration after birth. However, this initial benefit is rapidly lost following the switch to IPPV. The optimal approach for ventilating CDH infants at birth is unknown. While an SI improves lung aeration in immature lungs, its effect on the hypoplastic lung is unknown. This study h...
Source: Pediatric Research - November 11, 2023 Category: Pediatrics Authors: Lauren Hadley Andreas W Flemmer Marcus J Kitchen Michelle K Croughan Kelly J Crossley Katie L Lee Erin McGillick Megan J Wallace James T Pearson Philip DeKoninck Ryan Hodges Arjan B Te Pas Stuart B Hooper Marta Thio Source Type: research
Sustained inflation improves initial lung aeration in newborn rabbits with a diaphragmatic hernia
CONCLUSION: While an SI improved the rate and uniformity of lung aeration in both DH and control kittens, greater consideration of the post-SI ventilation strategy is required to sustain this benefit.IMPACT: Compared to intermittent positive pressure ventilation (IPPV), an initial sustained inflation (SI) increased the rate and uniformity of lung aeration after birth. However, this initial benefit is rapidly lost following the switch to IPPV. The optimal approach for ventilating CDH infants at birth is unknown. While an SI improves lung aeration in immature lungs, its effect on the hypoplastic lung is unknown. This study h...
Source: Pediatric Research - November 11, 2023 Category: Pediatrics Authors: Lauren Hadley Andreas W Flemmer Marcus J Kitchen Michelle K Croughan Kelly J Crossley Katie L Lee Erin McGillick Megan J Wallace James T Pearson Philip DeKoninck Ryan Hodges Arjan B Te Pas Stuart B Hooper Marta Thio Source Type: research
Case report: Coexistence of Jacobs syndrome, congenital adrenal hyperplasia, and ambiguous genitalia in a male infant
Key Clinical MessageJacobs syndrome and congenital adrenal hyperplasia are separate entities but share common clinical features such as ambiguous genitalia. Further studies are needed to conclude the relationship between Jacobs syndrome and congenital adrenal hyperplasia.AbstractA 5-month-old male infant was evaluated for ambiguous genitalia. Examination revealed cryptorchidism, inguinal hernia, long phallus, and Grade 3 scrotal hypospadias. Serum 17-OH progesterone was high and chromosomal analysis showed 47XYY/45XO. A diagnosis of Jacobs and CAH was made. The parents were counseled about the patient's condition. He was g...
Source: Clinical Case Reports - November 10, 2023 Category: General Medicine Authors: Qaisar Ali Khan,
Faiza Amatul ‐Hadi,
Amritpal Kooner,
Amber Lee,
Rahma Ahmed,
Adithya Nadella,
Harshawardhan Pande,
Yaxel Levin‐Carrion,
Muhammad Afzal,
Moses Alfaro Tags: CASE REPORT Source Type: research
Comment to: AI ’s deep dive into complex pediatric inguinal hernia issues—a challenge to traditional guidelines?
(Source: Hernia)
Source: Hernia - November 10, 2023 Category: Sports Medicine Source Type: research
Can Generative AI assist pediatric inguinal hernia issues?
(Source: Hernia)
Source: Hernia - November 8, 2023 Category: Sports Medicine Source Type: research
Functional lung imaging of 2-year-old children after congenital diaphragmatic hernia repair using dynamic mode decomposition MRI
ConclusionsDMD MRI can obtain pulmonary functional information in 2-year-old CDH patients. The results obtained with DMD MRI correlate with DCE MRI, without the need for ionising radiation or exposure to contrast agents. While further studies with larger cohorts are warranted, DMD MRI is a promising option for functional lung imaging in CDH patients.Clinical relevance statementWe demonstrate that pulmonary ventilation and perfusion information can be obtained in 2-year-old patients after CDH repair, without the need for ionising radiation or contrast agents by utilising non-contrast-enhanced MRI acquisitions together with ...
Source: European Radiology - November 8, 2023 Category: Radiology Source Type: research
Can Generative AI assist pediatric inguinal hernia issues?
(Source: Hernia)
Source: Hernia - November 8, 2023 Category: Sports Medicine Source Type: research
Long-term cosmetic outcomes of the slit-slide procedure for umbilical hernia repair in children
ConclusionThe slit-slide procedure is not only effective and safe, but it achieves a satisfactory aesthetic outcome. (Source: Surgery Today)
Source: Surgery Today - November 7, 2023 Category: Surgery Source Type: research
Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension
Long-term outcomes of persistent pulmonary hypertension of newborn (PPHN) depend on disease severity, duration of ventilation, and associated anomalies. Congenital diaphragmatic hernia survivors may have respiratory morbidities and developmental delay. The presence of PPHN is associated with increased mortality in hypoxic-ischemic encephalopathy, though the effects on neurodevelopment are less clear. Preterm infants can develop pulmonary hypertension (PH) early in the postnatal course or later in the setting of bronchopulmonary dysplasia (BPD). BPD-PH is associated with higher mortality, particularly within the first year....
Source: Clinics in Perinatology - November 6, 2023 Category: Perinatology & Neonatology Authors: Emily S. Stieren, Deepika Sankaran, Satyan Lakshminrusimha, Catherine A. Rottkamp Source Type: research
A qualitative study of groin hernia management in adolescents
CONCLUSIONS: This study found a lack of consensus and uniformity on the management of groin hernias in adolescents. Increased research efforts producing clinical guidelines are needed.FUNDING: This study was funded by the Michaelsen Foundation, the Aage and Johanne Louis-Hansens Foundation, Direktør Emil C. Hertz and Hustru Inger Hertz' Foundation, and the Torben and Alice Frimodts Foundation. The funders had no role in the design, conduct or reporting of the study.TRIAL REGISTRATION: not relevant.PMID:37897389 (Source: Danish Medical Journal)
Source: Danish Medical Journal - October 28, 2023 Category: General Medicine Authors: Hugin Reistrup Joachim Hh Olsen Siv Fonnes Jacob Rosenberg Source Type: research
