Separation and confinement anxiety in a golden retriever × standard poodle dog
Can Vet J. 2024 Feb;65(2):141-145.ABSTRACTAn 8-month-old spayed female golden retriever × standard poodle dog was presented for assessment because of vocalization, destructive behavior, and urination when left home alone and confined in a crate. Previous treatments included multiple medications, graduated departures, decoupling of departure cues, and punishmentbased techniques. Adverse reactions to paroxetine and lorazepam were noted before successful treatment with clomipramine, "safe haven" training, and behavior modification. Key clinical message: Separation anxiety is a common behavioral disorder in dogs. It is often ...
Source: The Canadian Veterinary Journal - February 2, 2024 Category: Veterinary Research Authors: Anneliese Heinrich Christine Calder Source Type: research

Separation and confinement anxiety in a golden retriever × standard poodle dog
Can Vet J. 2024 Feb;65(2):141-145.ABSTRACTAn 8-month-old spayed female golden retriever × standard poodle dog was presented for assessment because of vocalization, destructive behavior, and urination when left home alone and confined in a crate. Previous treatments included multiple medications, graduated departures, decoupling of departure cues, and punishmentbased techniques. Adverse reactions to paroxetine and lorazepam were noted before successful treatment with clomipramine, "safe haven" training, and behavior modification. Key clinical message: Separation anxiety is a common behavioral disorder in dogs. It is often ...
Source: The Canadian Veterinary Journal - February 2, 2024 Category: Veterinary Research Authors: Anneliese Heinrich Christine Calder Source Type: research

Separation and confinement anxiety in a golden retriever × standard poodle dog
Can Vet J. 2024 Feb;65(2):141-145.ABSTRACTAn 8-month-old spayed female golden retriever × standard poodle dog was presented for assessment because of vocalization, destructive behavior, and urination when left home alone and confined in a crate. Previous treatments included multiple medications, graduated departures, decoupling of departure cues, and punishmentbased techniques. Adverse reactions to paroxetine and lorazepam were noted before successful treatment with clomipramine, "safe haven" training, and behavior modification. Key clinical message: Separation anxiety is a common behavioral disorder in dogs. It is often ...
Source: The Canadian Veterinary Journal - February 2, 2024 Category: Veterinary Research Authors: Anneliese Heinrich Christine Calder Source Type: research

Separation and confinement anxiety in a golden retriever × standard poodle dog
Can Vet J. 2024 Feb;65(2):141-145.ABSTRACTAn 8-month-old spayed female golden retriever × standard poodle dog was presented for assessment because of vocalization, destructive behavior, and urination when left home alone and confined in a crate. Previous treatments included multiple medications, graduated departures, decoupling of departure cues, and punishmentbased techniques. Adverse reactions to paroxetine and lorazepam were noted before successful treatment with clomipramine, "safe haven" training, and behavior modification. Key clinical message: Separation anxiety is a common behavioral disorder in dogs. It is often ...
Source: The Canadian Veterinary Journal - February 2, 2024 Category: Veterinary Research Authors: Anneliese Heinrich Christine Calder Source Type: research

Separation and confinement anxiety in a golden retriever × standard poodle dog
Can Vet J. 2024 Feb;65(2):141-145.ABSTRACTAn 8-month-old spayed female golden retriever × standard poodle dog was presented for assessment because of vocalization, destructive behavior, and urination when left home alone and confined in a crate. Previous treatments included multiple medications, graduated departures, decoupling of departure cues, and punishmentbased techniques. Adverse reactions to paroxetine and lorazepam were noted before successful treatment with clomipramine, "safe haven" training, and behavior modification. Key clinical message: Separation anxiety is a common behavioral disorder in dogs. It is often ...
Source: The Canadian Veterinary Journal - February 2, 2024 Category: Veterinary Research Authors: Anneliese Heinrich Christine Calder Source Type: research

Separation and confinement anxiety in a golden retriever × standard poodle dog
Can Vet J. 2024 Feb;65(2):141-145.ABSTRACTAn 8-month-old spayed female golden retriever × standard poodle dog was presented for assessment because of vocalization, destructive behavior, and urination when left home alone and confined in a crate. Previous treatments included multiple medications, graduated departures, decoupling of departure cues, and punishmentbased techniques. Adverse reactions to paroxetine and lorazepam were noted before successful treatment with clomipramine, "safe haven" training, and behavior modification. Key clinical message: Separation anxiety is a common behavioral disorder in dogs. It is often ...
Source: The Canadian Veterinary Journal - February 2, 2024 Category: Veterinary Research Authors: Anneliese Heinrich Christine Calder Source Type: research

Separation and confinement anxiety in a golden retriever × standard poodle dog
Can Vet J. 2024 Feb;65(2):141-145.ABSTRACTAn 8-month-old spayed female golden retriever × standard poodle dog was presented for assessment because of vocalization, destructive behavior, and urination when left home alone and confined in a crate. Previous treatments included multiple medications, graduated departures, decoupling of departure cues, and punishmentbased techniques. Adverse reactions to paroxetine and lorazepam were noted before successful treatment with clomipramine, "safe haven" training, and behavior modification. Key clinical message: Separation anxiety is a common behavioral disorder in dogs. It is often ...
Source: The Canadian Veterinary Journal - February 2, 2024 Category: Veterinary Research Authors: Anneliese Heinrich Christine Calder Source Type: research

Separation and confinement anxiety in a golden retriever × standard poodle dog
Can Vet J. 2024 Feb;65(2):141-145.ABSTRACTAn 8-month-old spayed female golden retriever × standard poodle dog was presented for assessment because of vocalization, destructive behavior, and urination when left home alone and confined in a crate. Previous treatments included multiple medications, graduated departures, decoupling of departure cues, and punishmentbased techniques. Adverse reactions to paroxetine and lorazepam were noted before successful treatment with clomipramine, "safe haven" training, and behavior modification. Key clinical message: Separation anxiety is a common behavioral disorder in dogs. It is often ...
Source: The Canadian Veterinary Journal - February 2, 2024 Category: Veterinary Research Authors: Anneliese Heinrich Christine Calder Source Type: research

Inhibitory Actions of Antidepressants, Hypnotics, and Anxiolytics on Recombinant Human Acetylcholinesterase Activity
Biol Pharm Bull. 2024;47(1):328-333. doi: 10.1248/bpb.b23-00719.ABSTRACTAlzheimer's disease (AD) is accompanied by behavioral and psychological symptoms of dementia (BPSD), which is often alleviated by treatment with psychotropic drugs, such as antidepressants, hypnotics, and anxiolytics. If these drugs also inhibit acetylcholinesterase (AChE) activity, they may contribute to the suppression of AD progression by increasing brain acetylcholine concentrations. We tested the potential inhibitory effects of 31 antidepressants, 21 hypnotics, and 12 anxiolytics on recombinant human AChE (rhAChE) activity. At a concentration of 1...
Source: Biological and Pharmaceutical Bulletin - January 31, 2024 Category: Drugs & Pharmacology Authors: Keisuke Obara Haruka Mori Suzune Ihara Kento Yoshioka Yoshio Tanaka Source Type: research

Molecules, Vol. 29, Pages 676: Direct Immersion & ndash;Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood disorders, including amitriptyline, citalopram, fluoxetine, paroxetine, sertraline, trazodone, duloxetine, venlafaxine, lamotrigine, quetiapine, olanzapine, and mirtazapine. The analysis is carried out using high-performance liquid chromatography coupled with mass spectroscopy. The proposed DI-SPME/LC-MS method allows for a simple and quick sc...
Source: Molecules - January 31, 2024 Category: Chemistry Authors: Magdalena Świądro-Piętoń Dominika Dudek Renata Wietecha-Pos łuszny Tags: Article Source Type: research

The Practice of Prescribing Antidepressants During Pregnancy and Breastfeeding Among Mental Health Practitioners in Tertiary Care Centers in Oman
CONCLUSIONS: There was inconsistency among mental health practitioners in making prescription decisions and in their prescribing patterns.PMID:38264515 | PMC:PMC10801695 | DOI:10.5001/omj.2023.123 (Source: Oman Medical Journal)
Source: Oman Medical Journal - January 24, 2024 Category: Middle East Health Authors: Salim Al Kasbi Yousif Obaid Samir Al Adawi Sanjay Jaju Source Type: research

Antidepressant sertraline increases thioflavin-S and Congo red deposition in APPswe/PSEN1dE9 transgenic mice
Conclusion: These findings suggest a potential role of sertraline in AD pathogenesis, emphasizing the need to reassess the use of these antidepressants in patients with AD. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 8, 2024 Category: Drugs & Pharmacology Source Type: research

Perinatal Depression: A Guide to Detection and Management in Primary Care
Conclusions: These clinically relevant data can support the delivery of high-quality care by PCCs. Risks and benefits of PD treatments and the consequences of untreated PD should be discussed with patients to support informed decision making. (Source: Journal of the American Board of Family Medicine)
Source: Journal of the American Board of Family Medicine - January 5, 2024 Category: Primary Care Authors: Dama, M. H., Van Lieshout, R. J. Tags: Clinical Review Source Type: research

Exploring the incidence and etiopathogenesis of pathological yawning as adverse side effect of psychotropic drugs
CONCLUSION: The neural mechanism and physiology of yawning are explained. This study stresses that a health care professional, particularly mental health professionals and neurologists, should be aware of the importance of PY to deliver the best for the patients under their care. (Neuropsychopharmacol Hung 2023; 25(4): 194-205)PMID:38170730 (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - January 3, 2024 Category: Psychiatry Authors: Anusa Arunachalam Mohandoss Rooban Thavarajah Source Type: research