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Intranasal delivery of paroxetine: A preclinical study on pharmacokinetics, depressive-like behaviour, and neurochemical sex differences
Biochem Pharmacol. 2024 Mar 29:116184. doi: 10.1016/j.bcp.2024.116184. Online ahead of print.ABSTRACTTreatment of major depressive disorder remains a major unmet clinical need. Given the advantages of intranasal administration for targeted brain delivery, the present study aimed at investigating the pharmacokinetics of paroxetine, after its intranasal instillation and assessing its potential therapeutic effect on female and male mice subjected to unpredictable chronic mild stress (UCMS) protocol. IN administration revealed direct nose to-brain paroxetine delivery but dose- and sex-dependent differences. Pharmacokinetics wa...
Source: Biochemical Pharmacology - March 31, 2024 Category: Drugs & Pharmacology Authors: Soraia Silva Joana Bicker S Fialho Susana Cunha Am ílcar Falcão Ana Fortuna Source Type: research

The hippocampal Salt-Inducible Kinase 2-CREB-Regulated Transcription Co-activator 1 system mediates the antidepressant actions of paroxetine in mice
Behav Brain Res. 2024 Mar 27:114972. doi: 10.1016/j.bbr.2024.114972. Online ahead of print.ABSTRACTThe hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor (SSRI). Recent studies have indicated that paroxetine also modulates several pharmacological targets other than the 5-HT ...
Source: Behavioural Brain Research - March 29, 2024 Category: Neurology Authors: Xiang-Ming Cai Xiao-Yu Sun Rui Li Pei-Juan Wang Jian-Cheng Qi Yu-Xin Ge Lei Yang Source Type: research

The hippocampal Salt-Inducible Kinase 2-CREB-Regulated Transcription Co-activator 1 system mediates the antidepressant actions of paroxetine in mice
Behav Brain Res. 2024 Mar 27:114972. doi: 10.1016/j.bbr.2024.114972. Online ahead of print.ABSTRACTThe hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor (SSRI). Recent studies have indicated that paroxetine also modulates several pharmacological targets other than the 5-HT ...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Xiang-Ming Cai Xiao-Yu Sun Rui Li Pei-Juan Wang Jian-Cheng Qi Yu-Xin Ge Lei Yang Source Type: research

Combining SSRIs With Oral Anticoagulants Found to Increase Risk of Major Bleeding
People who take serotonin reuptake inhibitors (SSRIs) and oral anticoagulants have an increased risk of multiple types of major bleeding compared with people who take only oral anticoagulants, astudy inJAMA Network Open has found. The study findings also showed that bleeding risk differs depending on the type of anticoagulant.Christel Renoux, M.D., Ph.D., of Jewish General Hospital in Montreal and colleagues examined data from 331,305 patients in the United Kingdom aged 60 years or older who had atrial fibrillation and began taking oral anticoagulants between January 2, 1998, and March 29, 2021. The researchers included an...
Source: Psychiatr News - March 26, 2024 Category: Psychiatry Tags: adverse event anticoagulant bleeding blood thinner JAMA Network Open risk factor selective serotonin reuptake inhibitor SSRI warfarin Source Type: research

66-Year-Old Woman With Fatigue and Hypotension
A 66-year-old woman presented to the emergency department with progressive fatigue, weakness, diarrhea, and hypotension of 3 weeks ’ duration. Her symptoms had been gradually worsening without any clear inciting event. Her medical history was notable for ileocolonic stricturing Crohn disease treated with ileocecectomy 21 years previously, Charcot-Marie-Tooth disease (CMT), obesity, osteoporosis, depression, and dyslipidemia. Her medications had included alendronate, azathioprine for her Crohn disease, and paroxetine for depression, but she had stopped taking the latter 2 medications when her current symptoms started. (So...
Source: Mayo Clinic Proceedings - March 23, 2024 Category: Internal Medicine Authors: Thomas W. Fredrick, Ruth E. DeFoster Tags: Residents ’ clinic Source Type: research

Current Understanding of Compulsive Sexual Behavior Disorder and Co-occurring Conditions: What Clinicians Should Know about Pharmacological Options
AbstractCompulsive sexual behavior disorder (CSBD) has recently been recognized as a psychiatric disorder. Pharmacological treatments for CSBD have received little study and thus have limited empirical support. The main objective of the present work is to review existing literature on the efficacy of different drugs on the symptomatology of CSBD, including the subtype of problematic pornography use (PPU). The main pharmacological approaches to treating CSBD have included opioid antagonists (naltrexone and nalmefene), selective serotonin reuptake inhibitors (paroxetine, citalopram, fluoxetine, and sertraline), mood stabiliz...
Source: CNS Drugs - March 14, 2024 Category: Neurology Source Type: research

Paroxetine Effect on Nerve Growth Factor, Human Neurotrophin-4, Brain-Derived Neurotrophic Factor Levels in Post-stroke Depression
AbstractThe aim of this study is to explore paroxetine ’s effect on nerve growth factor (NGF), human neurotrophin-4 (NT-4), and brain-derived neurotrophic factor (BDNF) levels in post-stroke depression. Ninety-two post-stroke depression patients from April 2021 to April 2023 in our hospital were selected and numbered 1 to 92 after enrollment. Forty-si x patients with odd number and 46 patients with even number were, respectively, included in the control and observation group. In addition to basic treatment, control group was treated with flupentixol melitracen tablets orally, and observation group received paroxetine hyd...
Source: Molecular Neurobiology - March 5, 2024 Category: Neurology Source Type: research

Leptin, Nesfatin-1, Orexin-A, and Total Ghrelin Levels in Drug-Naive Panic Disorder
CONCLUSION: This study reports that PD, like other anxiety disorders, may affect serum nesfatin-1, leptin, orexin-A, and total ghrelin levels, and there may be a relationship between PD treatment and the levels of these neuropeptides. The variability of this relationship among the neuropeptides examined indicates that various factors other than treatment play a role in this process.PMID:38433413 | DOI:10.30773/pi.2023.0309 (Source: Psychiatry Investigation)
Source: Psychiatry Investigation - March 4, 2024 Category: Psychiatry Authors: Dilek Örüm Sevda Korkmaz Nevin İlhan Mehmet Hamdi Örüm Murad Atmaca Source Type: research

Leptin, Nesfatin-1, Orexin-A, and Total Ghrelin Levels in Drug-Naive Panic Disorder
CONCLUSION: This study reports that PD, like other anxiety disorders, may affect serum nesfatin-1, leptin, orexin-A, and total ghrelin levels, and there may be a relationship between PD treatment and the levels of these neuropeptides. The variability of this relationship among the neuropeptides examined indicates that various factors other than treatment play a role in this process.PMID:38433413 | PMC:PMC10910167 | DOI:10.30773/pi.2023.0309 (Source: Psychiatry Investigation)
Source: Psychiatry Investigation - March 4, 2024 Category: Psychiatry Authors: Dilek Örüm Sevda Korkmaz Nevin İlhan Mehmet Hamdi Örüm Murad Atmaca Source Type: research