Gene-sex interaction in Hypercompetitive Attitude suggests beneficial effect of the DRD4 7-repeat allele in adaptation.
Authors: Bircher J, Kotyuk E, Fulop M, Vereczkei A, Ronai Z, Varga K, Szekely A Abstract Twin studies provide evidence for the heritability of social attitudes, e.g. competitiveness, however, there are no psychogenetic association results linking competitive attitudes to genetic polymorphisms. Candidate gene studies report association with competitiveness-related phenotypes, risk taking for example was linked with the 7-repeat allele of the dopamine D4 receptor gene. This polymorphism has been studied extensively with novelty seeking and certain psychiatric disorders, as it plays a crucial role in molecular genetic...
Source: Neuropsychopharmacologia Hungarica - August 7, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

The effect of acute and repeated administration of buspirone, 8-OHDPAT and fluoxetine on haloperidol-induced extrapyramidal symptoms.
CONCLUSION: It may be concluded that buspirone and 8-OHDPAT improves extrapyramidal symptoms in a haloperidol-induced Parkinsonism model probably via activation of 5-HT₁A receptors. However, further investigations should be carried out to clarify the exact mechanism of interaction between 5-HT₁A and DA receptors. PMID: 31378723 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - August 7, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Novel findings concerning the heritability of IQ].
Authors: Ujma PP Abstract IQ is a psychological indicator with exceptional psychometric properties and substantial real-life predictive power. Behavior genetic results have long suggested that IQ is strongly heritable, that is, inter-individual IQ differences are mostly due to genetic differences, and that the effects of the environment shared by siblings, such as the family's place of residence or socioeconomic status, is minimal. Recently these observations were confirmed by quantitative genetic studies of unprecedented sample sizes, SNP heritability studies combining quantitative and molecular genetic approaches...
Source: Neuropsychopharmacologia Hungarica - August 7, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Cotard-syndrome associated with Hashimoto encephalopathy: a case report].
Authors: Hajnal L, Lazary J Abstract There is a growing body of data on encephalopathy-related psychiatric syndromes in the literature, however, clinical management of them still remains a great challenge. Although organic background of the rarely identified Cotard-syndrome has been reported in numerous pathological states, Hashimoto-encephalopathy has not been published in association with this clinical phenotype so far. In this paper we present a case of a 44 year old woman, who previously never had a psychiatric disorder and her clinical symptoms corresponded to Cotard II syndrome. She produced psychotic depress...
Source: Neuropsychopharmacologia Hungarica - August 7, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Dimensions of mentalization in psychotic disorders].
Authors: Fekete K, Torok E, Kelemen O, Makkos Z, Csigo K, Keri S Abstract The clinical assessment of mentalization became one of the most important issues in clinical psychology and psychiatry. Despite extensive research efforts, the exact definition, classification, and evaluation of mentalization is unresolved, especially in psychotic disorders. The primary purpose of the present study was to investigate the factor structure of the Mentalization Questionnaire. In addition, we investigated the relationship between the dimensions of mentalization and the positive, negative, and general symptoms of psychotic disorde...
Source: Neuropsychopharmacologia Hungarica - April 11, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Significance of the endocannabinoid system in migraine].
Authors: Gecse K, Bagdy G, Juhasz G Abstract Based on the traditional pain-relieving effect of Cannabis species an endogenous cannabinoidlike system was discovered in the human body. Endocannabinoids have important role in the homeostasis of the body, such as stress response and mood control, feeding behaviour, energy balance and metabolism, immunological processes, and also play important role in controlling pain processing. Previous studies suggested that an endokannabinoid dysfunction, namely endokannabinoid deficit, might contribute to the development of migraine and its chronification. Although, the exact natu...
Source: Neuropsychopharmacologia Hungarica - April 11, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Anxiety and depression - the role of blood-brain barrier integrity].
Authors: Gal Z, Huse RJ, Gonda X, Kumar S, Juhasz G, Bagdy G, Petschner P Abstract Among mental illnesses, anxiety disorders represent the second most frequent disorder. According to WHO Survey 2017, 264 million people suffer from their different types globally. The emergence of anxiety disorders can often increase the likelihood of developing other psychiatric illnesses such as depression, which is the most common mental illness with 300 million people affected worldwide. Although the two diseases mentioned above are widespread throughout the world, the exact physiological causes of their development and the way t...
Source: Neuropsychopharmacologia Hungarica - April 11, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

Transcriptomic changes following chronic administration of selective serotonin reuptake inhibitors: a review of animal studies.
Authors: Kumar S, Gal Z, Gonda X, Huse RJ, Juhasz G, Bagdy G, Petschner P Abstract The review focuses on transcriptomic changes following treatment with serotonin reuptake inhibitor (SSRI) antidepressants. We aimed to overview results of the most established methods for the investigation of the gene expression alterations including northern blotting, in situ hybridization, quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), microarray and RNAseq in various brain regions and after chronic treatment protocols. In spite of some measurable changes in serotonin system mRNA expression, serotonin trans...
Source: Neuropsychopharmacologia Hungarica - April 11, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Highlights of peripheral biomarkers in major depressive disorder: focus on HPA-axis, inflammation and neurotrophic factors].
Authors: Lazary J Abstract Investigations intensively focus on peripheral biomarkers in major depressive disorder (MDD), however, an up-to-date amd specific tool is still not available. There is an increasing body of data in the literature concerning this issue and the majority of this confirms that most promising markers are related to the HPA axis, inflammation and neurotrophic factors. Results from the addressed area suggest that testing multiple markers together can provide a valuable outcome in concerning diagnosis, treatment selection and monitoring. Several influencing factors altering the levels of biomarke...
Source: Neuropsychopharmacologia Hungarica - February 24, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[The continuum hypothesis of eating disorders, the evolution of a model from 1970's to the present].
Authors: Abraham I Abstract Classification and definition of criteria for eating disorders (ED) have been modified in the last decades due to changing theories about these disorders. The academic approach has been transformed from time to time by results from studies with increasing number of subjects and updated psychological tools. Investigation of EDs means a great challenge for researchers since they constitute a heterogeneous group and exhibit a dynamically variable manifestation and chronological progress. The author provides an overview on the different theories and related most significant results. Despite ...
Source: Neuropsychopharmacologia Hungarica - February 24, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Effect of placebo response on results of antidepressant clinical trials].
Authors: Pogany L Abstract Provocative data have been published regarding the results of clinical trials executed in order to assess the efficacy of antidepressants (AD) during the past years. Beside the continuously increasing placebo response the efficacy of ADs could not be differentiated from the effect of placebo in more than half of the studies. Several factors have been identified in the background of this phenomenon, researchers have proposed numerous possible solutions for this issue, including systematic re-evaluation of data, reconsideration of tools used for assessment of efficacy, of study design and o...
Source: Neuropsychopharmacologia Hungarica - February 24, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[The association between the serotonin receptor family and depression].
Authors: Szekeres G Abstract It is commonplace that depression is a heterogeneous mental disorder and this fact is the main driver of seek for aetiology and therapeutic opportunities. Selective serotonin reuptake inhibitors emerging in the 1980s are still among the most commonly prescribed medicines in the world. Due to their use, large groups of patients who previously remained untreated or treated at the cost of unwanted side effects of older antidepressants have chance to receive more optimal therapy. The background of the potential aetiology is multifaceted. However, we can point out that, according to the huge...
Source: Neuropsychopharmacologia Hungarica - February 24, 2019 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Effect of antidepressants in comorbid oncological and depressed patients].
Authors: Kovacs G, Peter L Abstract When facing comorbidity, effects of medicating one disorder on the other disease is a key question for the clinician. As depression influences both development and outcome of oncological diseases, early diagnosis and therapy, primarily with antidepressants, is of paramount importance. This paper gives a survey on the effects of antidepressants on comorbid mood disorders, on the course of cancerous diseases and on the tumor itself. Response to therapy is similar for patients with comorbid and primary depression, just as there is no significant difference in tolerability. Early stu...
Source: Neuropsychopharmacologia Hungarica - November 22, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Psychological disorders and tumorous diseases].
Authors: Lazary J Abstract Oncopsychology affects and intensively increasing number of patients due to the growing prevalence of cancers and the rapid development of oncological therapies. The comorbidity between tumorous diseases and psychiatric disorders has been known for a long time but its significance has become outstanding in the recent years. The relationship between these two types of disorders is considerably complex and may have determining consequences for clinical practice therefore dealing with these conditions is a serious challenge for clinicians. Our knowledge concerning the association of mental i...
Source: Neuropsychopharmacologia Hungarica - November 22, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[The role of positron emission tomography (PET) in tumor diagnostics and therapy monitoring].
Authors: Kajary K, Szekeres S, Lazar M, Nemeth A, Galgoczy H, Molnar P, Lengyel Z Abstract Positron emission tomography (PET) is a medical imaging method belonging to the realm of nuclear medicine. It has been a clinical research tool since the sixties but during the late nineties it became widely utilized in clinical practice too. PET technique requires special radioactive isotopes, which may be generated only in particle accelerators (cyclotrons) and their transport is limited owing to the short physical half-life. PET/CT was born from the combination of PET and CT (computer tomography). The first combined PET/CT...
Source: Neuropsychopharmacologia Hungarica - November 22, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Chemobrain].
Authors: Szentmartoni G, Makkos Z, Dank M Abstract Over the past ten years, in oncology there is an increased interest in understanding the cognitive dysfunction caused by chemotherapy also known as chemobrain or chemofog. As a result of oncological therapies the number of survivors of malignant diseases has increased considerably, but the side effects also appear to be more prevalent and severe including persistent cognitive symptoms. Symptoms of chemobrain include memory impairment, loss of concentration, speech and psychomotor deceleration, attention and learning coordination problems, and disturbance of executi...
Source: Neuropsychopharmacologia Hungarica - November 22, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Prediction of response to lamotrigine treatment in bipolar outpatients: a multicentric, 6-month, prospective, observational study].
Authors: Gonda X, Rihmer Z Abstract In case of a major depressive episode it is crucial to establish whether this is a depressive episode in the course of a bipolar I or bipolar II disorder or a "true" unipolar major depression which is possible through screening for lifetime manic or hypomanic episodes and can be facilitated by the use of the Hypomania Checklist (HCL-32). In cases where (hypo)mania is present in the anamnesis, mood stabilising treatment is warranted even in cases where depressive symptoms predominate the clinical course. However, the association between hypomania in the history and effic...
Source: Neuropsychopharmacologia Hungarica - August 24, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Emotion regulation and heart rate variability].
Authors: Szemenyei E, Kocsel N, Orkenyi A, Kokonyei G Abstract Heart rate variability (HRV) has been receiving increasing attention not just in medical but also in psychological research. Several studies show that mental disorders are associated with lower levels of HRV. Therefore, HRV has been considered as a transdiagnostic biomarker. The current review spreads light on the possibility that in the connection of HRV and psychopathologies the deficits of emotion regulation or disregulated emotional states can be important mediators. Accordingly, we review the results of the questionnaire-based and experimental stud...
Source: Neuropsychopharmacologia Hungarica - August 24, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[The biological background of the comorbidity of depression and cancer].
Authors: Peter L Abstract Depression is a common comorbid condition in patients with cancer, but the background mechanisms underlying the relationship between depression and cancer are not well clarified. Depression and cancer are prevalent public health problems in the Western world. In this article, I review the recent knowledge regarding possible etiological mechanisms in particular biological contexts. Inflammation and chronic stress play a role in the development of both types of disease, which can explain high comorbidity. Depression in cancer patients increases the time of hospitalization and mortality, lowe...
Source: Neuropsychopharmacologia Hungarica - August 24, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

Hypocapnia and mental stress can trigger vicious circles in critically ill patients due to energy imbalance: a hypothesis presented through cardiogenic pulmonary oedema.
Authors: Sikter A Abstract The pathophysiologic significance of hypocapnia is strongly underestimated both in functional and organic diseases. Alterations of carbon dioxide levels immediately appear in the cytoplasm, causing abrupt pH changes. Compensatory mechanisms develop with latency, so intracellular alkalosis or acidosis can affect metabolism for hours/days. Hyperventilation alkalosis increases metabolic energy/O₂ demand, while ATP production is often reduced due to developing hypophosphatemia. A healthy organism serves the increased energy demand conveniently, as a consequence, the excitability of the cort...
Source: Neuropsychopharmacologia Hungarica - August 24, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

The development of a short version of TEMPS-A in Hungarian non-clinical samples.
CONCLUSIONS: The short version of the Hungarian TEMPS-A is a promising instrument both in clinical fields and for academic research. The newly developed short version proved to be a valid and reliable measure of affective temperaments. PMID: 29790847 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - May 27, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Assessing suicide risk using the Brief Suicide Questionnaire - preliminary results].
Authors: Rihmer Z, Dome P, Gonda X, Rihmer A, Belteczki Z Abstract The authors tested the clinical applicability of a self-developed, 6-item, clinician-rated questionnaire evaluating suicide risk in suicidal and non-suicidal psychiatric inpatients and healthy controls. Results have shown that the questionnaires able to detect marked suicide risk in psychiatric inpatients with a high sensitivity and specificity which indicates its usefulness and good applicability in clinical practice. PMID: 29790848 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - May 27, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[N-methyl-D-aspartate receptor antibody encephalitis: the Janus-faced disorder].
This article attempts to summarize the clinical features of this complex neuropsychiatric disorder with the aim to help its early recognition and to report the clinical course and the outcome of our six seropositive anti-NMDAR cases. The disease appears typically in young females and often combined with ovarian teratoma. However, the antibody production could develop without any malignancy. The course of the illness is usually monophasic, but 10% of the cases are relapsing. The anti-NMDAR encephalitis is the result of disturbed glutamatergic neurotransmission due to the internalization of the receptor-antibody complexes. T...
Source: Neuropsychopharmacologia Hungarica - May 27, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[The practical considerations of antidepressant use during pregnancy and breastfeeding].
Authors: Dome P, Faludi G Abstract Main indications of antidepressants (ADs) as major depressive disorder (MDD) and different kinds of anxiety disorders are quite prevalent during pregnancy and the postpartum period. Due to the possible hazards of in utero and breast milk exposition of ADs, both psychiatrists and mothers frequently have concerns about the use of ADs during the periods of pregnancy and breastfeeding. However, we should also bear in mind that affective disorders left untreated during these periods are also associated with health risks for the mother and the baby as well. Accordingly, the treatment of...
Source: Neuropsychopharmacologia Hungarica - May 27, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Genetic association analyses of the endocannabinoid system on anxious phenotype].
CONCLUSION: Our results confirmed earlier positive data on the association between ECS and anxious phenotype. According to our findings ECS plays a significant role in the pathomechanism of anxious disorders by a complex mechanism of genetic interaction with the serotonin transporter gene and childhood traumas. PMID: 29411704 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - February 9, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Vascular endothelial growth factor (VEGF) as a potential biomarker in major depressive disorder].
CONCLUSION: Our results confirm the significant role of VEGF signaling in the pathomechanism of major depression disorder. These data suggest that high baseline VEGF level can be a predictor for lack of therapy response, thus VEGF can be regarded as a potential biomarker for treatment resistance in major depression disorder. PMID: 29411705 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - February 9, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Maternal bonding style, cholinergic receptor gene polymorphisms in association with smoking-related depressive symptoms].
CONCLUSIONS: Our results confirmed the genetic effect of CHRNA4 and CHRNB2 on smoking-related depression. These findings suggest that a genetically vulnerable subgroup can be distinguished among smokers and this subphenotype is more prone to withdrawal and depressive symptoms. Our data suggest that suicidal risk depends on both CHRNB2 gene variants and maternal bonding style. Pharmacogenetic concerns of CHRNA4 and CHRNB2 genes might be significant considering suicide as side effect of quitting therapy. Further pharmacogenetic investigations are requierd to clarify this possibility. PMID: 29411706 [PubMed - in process] ...
Source: Neuropsychopharmacologia Hungarica - February 9, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Psychobiological background and clinical aspects of the placebo effect in psychiatry].
Authors: Pogany L Abstract The placebo-effect is present in almost every field of medicine, however, in the assessment of the effect of psychotropic drugs it is a major problem. The rise of the placebo-effect in clinical trials is observed during the last decades, in spite of all efforts to introduce new methods in clinical trials to overcome this problem and the number of studies aiming to unveil the mechanisms that lie in the background that this phenomenon have risen. A considerable amount of data has accumulated regarding the psychobiological background of placeboeffect, however, the details of underlying mecha...
Source: Neuropsychopharmacologia Hungarica - February 9, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[From stone-craved genes to Michelangelo: significance and different aspects of gene-environment interaction].
Authors: Lazary J Abstract Although genetic studies have improved a lot in recent years, without clinical relevance sometimes their significance is devalued. Reviewing the major milestones of psychogenomics it can be seen that break-through success is just a question of time. Investigations of direct effect of genetic variants on phenotypes have not yielded positive findings. However, an important step was taken by adapting the gene-environment interaction model. In this model genetic vulnerability stepped into the place of "stone craved" pathology. Further progress happened when studies of environmental ...
Source: Neuropsychopharmacologia Hungarica - February 9, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Assessing suicide risk based on a hierarchical classification of risk factors].
Authors: Rihmer Z, Dome P, Gonda X, Belteczki Z Abstract Suicide risk factors could be organised into a hierarchical order and a questionnaire constructed based on this hierarchical structure may help clinicians assess suicide risk. The paper presents analysis of the clinical utility of a questionnaire developed by the authors, in samples of suicidal and nonsuicidal psychiatric patients as well as among normal control subjects. Based on their results the authors suggest a shorter and expectedly more sensitive, 6-item version instead of the original 12-item version scale. PMID: 29306904 [PubMed - in process] (So...
Source: Neuropsychopharmacologia Hungarica - January 8, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[The importance of anxiety and depression in family practice].
We present two short questionnaires used for recognizing depression and acute suicide risk and describe their use in family/ general practice. PMID: 29306905 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - January 8, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Psychiatric disorders in epilepsy: clinical phenomena].
Authors: Szucs A, Horvath A, Fabo D, Szabo G, Kovacs A, Halasz P Abstract The frequent psychiatric comorbidity in epilepsy compromises the quality of life of those affected, further increasing their suicide risk and the high burden of stigmatisation. Out of adulthood epilepsies, mesio-temporal lobe epilepsy carries the highest cognitive and psychiatric risk, making mental health comorbidities its inherent features. The pathomechanism of the epilepsy-related mental health symptoms and conditions appears to be related to undetected subclinical seizures, postictal exhaustion and inhibition, and the non-REM sleep relat...
Source: Neuropsychopharmacologia Hungarica - January 8, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

New aspects in the pathomechanism of diseases of civilization, particularly psychosomatic disorders. Part 2. Chronic hypocapnia and hypercapnia in the medical practice.
Authors: Sikter A, Rihmer Z, Guevara R Abstract The authors seek to find new connections between recent results of biology and older theories. This paper aims to assemble the jigsaw puzzle. The theoretical background of the hypothesis was described in the previous issue of the journal (Sikter et al. 2017a). Human stress response often coexists with persistent hypocapnia or hypercapnia - developing via psychosomatic pathomechanism - which can lead to mental and psychosomatic illnesses. Chronic hypocapnia mainly generates hyperarousal disorders which may be reversible for an extended time, however, vicious cycles may...
Source: Neuropsychopharmacologia Hungarica - January 8, 2018 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[The methodology and sample description of the National Survey on Addiction Problems in Hungary 2015 (NSAPH 2015)].
Authors: Paksi B, Demetrovics Z, Magi A, Felvinczi K Abstract This paper introduces the methods and methodological findings of the National Survey on Addiction Problems in Hungary (NSAPH 2015). Use patterns of smoking, alcohol use and other psychoactive substances were measured as well as that of certain behavioural addictions (problematic gambling - PGSI, DSM-V, eating disorders - SCOFF, problematic internet use - PIUQ, problematic on-line gaming - POGO, problematic social media use - FAS, exercise addictions - EAI-HU, work addiction - BWAS, compulsive buying - CBS). The paper describes the applied measurement tec...
Source: Neuropsychopharmacologia Hungarica - September 19, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Clinical features of psychotic and non-psychotic bipolar patients].
CONCLUSIONS: Early onset of the disease, bipolar I diagnosis and comorbid personality disorder were typical of psychotic bipolar patients; in addition, suicide attempts and residual symptoms were more common compared to the non-psychotic group. LIMITATIONS: The relatively lower number of patients (89 and 80 patients) and the fact that the data were processed retrospectively limit the generalizability of our results. PMID: 28918417 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - September 19, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

New aspects in the pathomechanism of diseases of civilization, particularly psychosomatic disorders. Part 1. Theoretical background of a hypothesis.
Authors: Sikter A, Rihmer Z, Guevara R Abstract The stress defence-cascade is mostly not biphasic as Cannon thought, the sympathicotonic stress response is preceded by a vagotonic phase called freeze response. Alteration of the carbon dioxide level plays an important role during defence-cascade as its changes interfere with stress hormones, e.g. with catecholamines, thus affecting the degree of arousal. In case of humans, learned behaviour dominates instead of instinctive, so the fight-or-flight often lags; the consequence can be persistent hypocapnia or hypercapnia. The hypoventilation or hyperventilation may cont...
Source: Neuropsychopharmacologia Hungarica - September 19, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[About the association between antipsychotic medication and cardiovascular morbidity: epidemiology and possible background mechanisms].
Authors: Gaszner G, Barna G, Dome P Abstract The history of antipsychotics began with the discovery of chlorpromazine in the 1950s. Since then this group of medications has become one of the most important element of the armamentarium of psychopharmacology. While initially these pharmacons were used in the treatment of psychotic states (including psychotic mania) in the last approximately 10-15 years new indications - such as treatment of depressive, manic and mixed states and also mood-stabilization in bipolar disorder and also the treatment of major depressive disorder - for several second-generation antipsychoti...
Source: Neuropsychopharmacologia Hungarica - September 19, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Societal relevance of affective disorders with special respect to auto- and heteroagressive manifestations- Editorial].
Authors: Rihmer Z, Blazsek P PMID: 28467953 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - May 5, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Association between the 5-HTTLPR polymorphism of the serotonin transporter gene and suicide: a case-control pilot study].
CONCLUSIONS: Our pilot study did not support the supposed association between 5-HTTLPR and completed suicides or with violent completed suicides. However we found a significant association between sl genotype and suicide in young suicidals. PMID: 28467954 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - May 5, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

The impact of currently recommended antihypertensive therapy on depression and other psychometric parameters: preliminary communication.
CONCLUSIONS: Our results indicate that initiation of currently recommended antihypertensive medications in newly diagnosed patients may have a significant impact on psychological well-being of patients and could influence quality of life as well. PMID: 28467955 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - May 5, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Similarities and differences between bipolar disorder and hypertension: may be mania is the hypertension of the mood?]
Authors: Rihmer Z, Gonda X, Dome P, Harmati L, Nemcsik J Abstract A possibly shared pathophysiological background between bipolar disorders and essential hypertension is suggested by the several similarities and overlaps between their genetic background, underlying biological disturbances (including partially shared neuroanatomical and neurochemical correlates), concomitant personality and temperamental characteristics, precipitating factors, comorbidity and treatment response. In this paper we outline and extend our previously published hypothesis discussing the similar origins of these two biphasic/bidirectional ...
Source: Neuropsychopharmacologia Hungarica - May 5, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

Why are migraineurs more depressed? A review of the factors contributing to the comorbidity of migraine and depression.
Authors: Baksa D, Gonda X, Juhasz G Abstract The comorbidity of migraine and depression is well-known. Patients with both conditions show stronger headache-related symptoms, a more severe clinical course and higher risk for migraine chronification. Therefore, it's important to identify factors underlying comorbid migraine and depression. The growing body of literature suggests complex, biopsychosocial mechanisms in the background, including shared genetic risk factors and abnormal brain mechanisms, and also different environmental (stress) and psychological variables (for example: rumination, neuroticism). In this ...
Source: Neuropsychopharmacologia Hungarica - May 5, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Recognition, treatment and prevention of suicide in adulthoode - Guideline].
Authors: Rihmer Z, Nemeth A, Kurimay T, Perczel-Forintos D, Purebl G, Dome P PMID: 28467958 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - May 5, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Molecular Psychiatry Research in Hungary - Editorial].
Authors: Rethelyi JM PMID: 28259859 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - March 6, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

Potential salivary biomarkers and their genetic effects in a pilot study of adolescent boys with externalizing problems.
CONCLUSIONS: Our preliminary data suggest that salivary alpha-amylase might be used to further characterize subgroups within externalizing problems, however, this biomarker might be modified by certain genetic polymorphisms. PMID: 28259860 [PubMed - in process] (Source: Neuropsychopharmacologia Hungarica)
Source: Neuropsychopharmacologia Hungarica - March 6, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Investigation of CNTF, COMT, DDR1, DISC1, DRD2, DRD3, and DTNBP1 candidate genes in schizophrenia: Results from the Hungarian SCHIZOBANK Consortium].
In this study we investigated polymorphisms of 7 candidate genes in a Hungarian schizophrenia cohort. Candidate genes were chosen on the basis of previous results and biological plausibility. 390 patients were recruited in 5 centers in the framework of the Hungarian SCHIZOBANK Consortium, the schizophrenia sample was contrasted to 1069 healthy control individuals. In this sample SNPs of DDR1 and DRD2 genes demonstrated significant association with schizophrenia. The role of DDR1 and DRD2 genes in the etiology of schizophrenia warrant further investigation, based on their genomic localization and biological functions. P...
Source: Neuropsychopharmacologia Hungarica - March 6, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Modeling neurological and psychiatric disorders in vitro using induced pluripotent stem cells: highlighting findings in Alzheimer's disease and schizophrenia].
Authors: Hathy E, Kalman S, Apati A, Nemoda Z, Rethelyi JM Abstract Over the past decade we witnessed the birth of a new scientific area that lies at the borders of developmental biology, stem cell biology, basic and clinical neuroscience. In vitro disease modeling refers to the approach that exploits the capacity of stem cells for self-renewal and pluripotency by generating specific cell types that are relevant for a given disorder. Based on this method, neurological and psychiatric disorders can be investigated by differentiating stem cells into neurons in a dish, and studying the relevant neuronal populations af...
Source: Neuropsychopharmacologia Hungarica - March 6, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Review of the psychiatric aspects of anti-NMDA (N-methyl-D-aspartic acid) receptor encephalitis, case report, and our plans for a future study].
Authors: Herman L, Zsigmond IR, Peter L, Rethelyi JM Abstract Anti-NMDAR (N-methyl-D-aspartic acid receptor) encephalitis, first described in 2007, is a rare, autoimmune limbic encephalitis. In half of the cases anti-NMDAR antibodies are paraneoplastic manifestations of an underlying tumor (mostly ovarian teratoma). In the early stage of the disease psychiatric symptoms are prominent, therefore 60-70% of the patients are first treated in a psychiatric department. In most of the cases, typical neurological symptoms appear later. Besides the clinical picture and typical symptoms, verifying presence of IgG antibodies ...
Source: Neuropsychopharmacologia Hungarica - March 6, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[An attempt to identify 22q11.2 microdeletions in samples of the Hungarian schizophrenia DNA bank by multiplex ligation-based probe amplification (MLPA): literature review, methodology and results].
Authors: Klein I, Szocs K, Vincze K, Benkovits J, Somogyi S, Herman L, Rethelyi JM Abstract Schizophrenia is a severe debilitating psychiatric disorder, with a typical onset in adolescence or early adulthood. This condition is characterized by heterogeneous symptoms (hallucinations, delusions, disorganized behaviour, affective flattening, and social isolation) and a life-time prevalence of 0.5-1.2%. In spite of the efforts to uncover the etiology of the disorder, its pathogenesis and neurobiological background are poorly understood. Given the high heritability in schizophrenia, genetic research remains an important...
Source: Neuropsychopharmacologia Hungarica - March 6, 2017 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

[Comorbidity of psychiatric disorders and the characteristics of the therapy of the hospitalized patients].
Authors: Mora B, Peter L Abstract The aim of our retrospective study was to evaluate the diagnostic and therapeutic characteristics of 100 patients who were admitted in our psychiatric department from an index date. Previous investigation showed high prevalence of comorbidity in patients with psychiatric disorders. The most common psychiatric comorbidities included dementia (20%), alcohol dependence (14%) and unipolar depression (8%). The presence of somatic diseases was also high (73%), including cardiovascular (55%), endocrine (30%), neurological (17%), and gastroenterological (16 %) comorbid disorders. The most ...
Source: Neuropsychopharmacologia Hungarica - November 11, 2016 Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research