Mechanical strength affecting the penetration in microneedles and PLGA nanoparticle-assisted drug delivery: Importance of preparation and formulation
This study confirmed that PAX-NPs-DMNs can effectively improve the bioavailability of PAX and the mechanical strength of DMNs, which can easily penetrate the skin to provide sustained and painless delivery without causing adverse effects, thus offering a more convenient and effective method for central nervous diseases.PMID:38428314 | DOI:10.1016/j.biopha.2024.116339 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 1, 2024 Category: Drugs & Pharmacology Authors: Geng Lu Baohua Li Luping Lin Xiaofang Li Junfeng Ban Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against.METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method. The evidence was then evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. Recommendations were made after conse...
Source: Annals of Internal Medicine - February 26, 2024 Category: Internal Medicine Authors: Paula P Schnurr Jessica L Hamblen Jonathan Wolf Rachael Coller Claire Collie Matthew A Fuller Paul E Holtzheimer Ursula Kelly Ariel J Lang Kate McGraw Joshua C Morganstein Sonya B Norman Katie Papke Ismene Petrakis David Riggs James A Sall Brian Shiner Il Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against.METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method. The evidence was then evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. Recommendations were made after conse...
Source: Annals of Internal Medicine - February 26, 2024 Category: Internal Medicine Authors: Paula P Schnurr Jessica L Hamblen Jonathan Wolf Rachael Coller Claire Collie Matthew A Fuller Paul E Holtzheimer Ursula Kelly Ariel J Lang Kate McGraw Joshua C Morganstein Sonya B Norman Katie Papke Ismene Petrakis David Riggs James A Sall Brian Shiner Il Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against.METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method. The evidence was then evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. Recommendations were made after conse...
Source: Annals of Internal Medicine - February 26, 2024 Category: Internal Medicine Authors: Paula P Schnurr Jessica L Hamblen Jonathan Wolf Rachael Coller Claire Collie Matthew A Fuller Paul E Holtzheimer Ursula Kelly Ariel J Lang Kate McGraw Joshua C Morganstein Sonya B Norman Katie Papke Ismene Petrakis David Riggs James A Sall Brian Shiner Il Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against.METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method. The evidence was then evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. Recommendations were made after conse...
Source: Annals of Internal Medicine - February 26, 2024 Category: Internal Medicine Authors: Paula P Schnurr Jessica L Hamblen Jonathan Wolf Rachael Coller Claire Collie Matthew A Fuller Paul E Holtzheimer Ursula Kelly Ariel J Lang Kate McGraw Joshua C Morganstein Sonya B Norman Katie Papke Ismene Petrakis David Riggs James A Sall Brian Shiner Il Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against.METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method. The evidence was then evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. Recommendations were made after conse...
Source: Annals of Internal Medicine - February 26, 2024 Category: Internal Medicine Authors: Paula P Schnurr Jessica L Hamblen Jonathan Wolf Rachael Coller Claire Collie Matthew A Fuller Paul E Holtzheimer Ursula Kelly Ariel J Lang Kate McGraw Joshua C Morganstein Sonya B Norman Katie Papke Ismene Petrakis David Riggs James A Sall Brian Shiner Il Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
Safety Profile of Selective Serotonin Reuptake Inhibitors in Real-World Settings: A Pharmacovigilance Study Based on FDA Adverse Event Reporting System
CONCLUSIONS AND RELEVANCE: Most of our findings are consistent with those reported previously, but some AEs were not previously identified. However, AEs attributed to SSRIs remain ambiguous, warranting further validation. Applying data-mining methods to the FAERS database can provide additional insights that can assist in appropriately utilizing SSRIs.PMID:38407147 | DOI:10.1177/10600280241231116 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2024 Category: Drugs & Pharmacology Authors: Yi Zhao Yuzhou Zhang Lin Yang Kanghuai Zhang Sha Li Source Type: research
