UCLA-led team develops new method to study mitochondrial DNA diseases
Alexander Patananan
The process of transferring mitochondria between cells using the nanoblade technology.
A UCLA-led team of researchers has demonstrated a new method to conduct research on mitochondrial DNA diseases — a broad group of debilitating genetic disorders that can affect the brain, heart and muscles.
The new method, which utilizes a technology developed by UCLA researchers that opens holes in the cell membrane, is described in a study published today in Cell Metabolism. The researchers say that it could pave the way for specific research on how and why these diseases occur, and point to pathways to develo...
Source: UCLA Newsroom: Health Sciences - May 10, 2016 Category: Universities & Medical Training Source Type: news
Scientists may be able force cancer into dormant state
Stephen FellerTEL AVIV, Israel, Feb. 23 (UPI) -- A proof-of-concept drug that can "turn off" osteosarcoma cells may prevent cancer relapse, according to researchers in Tel Aviv. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 23, 2016 Category: Consumer Health News Source Type: news
New therapeutic pathway may keep cancer cells turned 'off'
A new study offers tangible evidence that it is possible to keep osteosarcoma lesions dormant using novel nanomedicines. Osteosarcoma is a cancer that develops in the bones of children and adolescents. It is one of the most aggressive cancers, with only a 15 per cent, five-year survival rate when diagnosed in an advanced metastatic stage. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 23, 2016 Category: Science Source Type: news
New therapeutic pathway may keep cancer cells turned 'off'
(American Friends of Tel Aviv University) A new Tel Aviv University study offers tangible evidence that it is possible to keep osteosarcoma lesions dormant using novel nanomedicines. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 23, 2016 Category: Cancer & Oncology Source Type: news
DNA imprinting defects associated with childhood osteosarcoma development and progression
(University of Minnesota Academic Health Center) Children diagnosed with osteosarcoma may be impacted by a DNA imprinting defect also found in parents, according to new research from the Masonic Cancer Center, University of Minnesota. DNA imprinting is a phenomenon in which just one of the two inherited genes is active while the other is present but inactive.The study is published now in the journal Oncotarget. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 26, 2016 Category: Cancer & Oncology Source Type: news
Catching up with Caitlynne: Climb every mountain
College student Caitlynne McGaff bounces from one adventure to the next. One weekend, she might be on stage, performing in the Complete Works of Willliam Shakespeare, (abridged) a rapid-fire tromp through the bard’s best works. The next she could be scaling mountains in Maine or jumping into the icy waters of the Atlantic. In December, she spent three weeks in South Africa on a service trip, teaching life skills to disadvantaged high school students.
She’s leading the life she and her parents envisioned in 2001, when Caitlynne, then 8, underwent a rotationplasty. After she was diagnosed with osteosarcoma at age 6, Cait...
Source: Thrive, Children's Hospital Boston - January 25, 2016 Category: Pediatrics Authors: Lisa Fratt Tags: Diseases & Conditions Our Patients’ Stories Mark Gebhardt osteosarcoma rotationplasty Source Type: news
Bang! Zap! Pow!
Graphic Novels Tackle Cancer Topics By Stacy Simon Understanding cancer can be tough for anyone, but this complicated disease can be even harder to explain to children and teenagers. The American Cancer Society Medikidz series of graphic novels uses superhero medical experts and cartoon cancer cells to help young readers understand what causes cancer and how it is diagnosed and treated. RESOURCES: ¡Pum! ¡Zas! ¡Uf!Medikidz Book SeriesSerie de libros infantiles MedikidzAmerican Cancer Society Bookstore For example, in one of the books in the series, What’s Up with Tiffany’s Dad? Me...
Source: American Cancer Society :: News and Features - December 16, 2015 Category: Cancer & Oncology Tags: ACS Programs and Services Skin Cancer - Melanoma Cancer in the Family Source Type: news
Antibody prevents degrading of bones in rare cancer
Stephen FellerCOPENHAGEN, Denmark, Dec. 2 (UPI) -- Researchers found an antibody could prevent up to 80 percent of bone degradation caused by osteosarcoma, which could help prevent amputation in young patients. (Source: Health News - UPI.com)
Source: Health News - UPI.com - December 2, 2015 Category: Consumer Health News Source Type: news
Researchers develop antibody to save cancerous bones
(University of Copenhagen, Biotech Research & Innovation Centre) Osteosarcoma is a rare cancer most often affecting adolescents and children. While most bone cancers have their origin in other body tissues and spread to the bones through metastases, OS originates in the bone tissue. At the Finsen Laboratory, University of Copenhagen researchers now shows that OS cells degrade the bone tissue through a completely different process than metastasized bone cancer. Through treatment with a specific antibody, the researchers blocked the process and reduced up to 80 percent of bone degradation in a cancer model. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - December 2, 2015 Category: Biology Source Type: news
Childhood Cancer Survivors at Risk for HospitalizationChildhood Cancer Survivors at Risk for Hospitalization
Childhood and young adult cancer survivors have higher rates of hospitalization, and osteosarcoma survivors face a risk for neurocognitive impairment later in life. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 24, 2015 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Chemo-resistant tumors targeted by BU School of Medicine researcher
(Boston University Medical Center) Rachel Flynn, Ph.D., assistant professor of pharmacology and medicine at Boston University School of Medicine, is the recipient of an Elsa U. Pardee award for approximately $148,000 for 'Targeting the Alternative Lengthening of Telomeres (ALT) Pathway in cancer.' This pathway is frequently reactivated in aggressive cancers such as osteosarcoma and glioblastoma, which are often resistant to standard chemotherapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 2, 2015 Category: Cancer & Oncology Source Type: news
Radiological Case: Osteoblastic OsteosarcomaRadiological Case: Osteoblastic Osteosarcoma
While osteosarcoma is usually diagnosed in younger patients, this case of a 43-year-old woman with a forearm mass demonstrates that it can occur at any age, with atypical presentation. Applied Radiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 7, 2015 Category: Consumer Health News Tags: Radiology Journal Article Source Type: news
Protein implicated in osteosarcoma's spread acts as air traffic controller
The investigation of a simple protein has uncovered its uniquely complicated role in the spread of the childhood cancer, osteosarcoma. It turns out the protein, called ezrin, acts like an air traffic controller, coordinating multiple functions within a cancer cell and allowing it to endure stress conditions encountered during metastasis. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 6, 2015 Category: Science Source Type: news
Protein implicated in osteosarcoma's spread acts as air traffic controller
(Georgetown University Medical Center) The investigation of a simple protein has uncovered its uniquely complicated role in the spread of the childhood cancer, osteosarcoma. It turns out the protein, called ezrin, acts like an air traffic controller, coordinating multiple functions within a cancer cell and allowing it to endure stress conditions encountered during metastasis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 6, 2015 Category: Cancer & Oncology Source Type: news
A fourth opinion saves Mahra’s arm from amputation
Mahra Saeed is at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center for her last checkup before heading home to the United Arab Emirates (UAE). The spunky 8-year-old sports a new dress and cowboy boots, and carries a large stack of thank you cards. She hands them out to oncologist Dr. Carlos Rodriguez-Galindo, nurse practitioner Annette Werger and other staff members, who try to contain their emotion as they read, “Thanks for helping me to fight cancer.”
Back up 10 months ago to August 2014, when Mahra fell at the park in her hometown of Al Ain and fractured her right arm. An x-ray and biopsy r...
Source: Thrive, Children's Hospital Boston - June 9, 2015 Category: Pediatrics Authors: Jenny Fernandez Tags: All posts Cancer Our patients’ stories Dana-Farber/Boston Children's Cancer and Blood Disorders Center osteosarcoma Source Type: news
