Cancer drug tested in pet dogs is now bound for human trials
(University of Illinois at Urbana-Champaign) Thanks to a new $2 million investment, a drug that spurs cancer cells to self-destruct while sparing healthy cells is on the road to human clinical trials. The compound, known as PAC-1, has so far proven safe and has promising anti-cancer effects in cell culture, in mouse models of cancer and in pet dogs with spontaneously occurring lymphomas and osteosarcomas. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 17, 2013 Category: Global & Universal Source Type: news
Turning a cancer diagnosis into a chance to help others
Virginia (photo credit Catherine Morris)
Virginia-Finigan Carter has a knack for turning things around.
At 13 years old, she fought through leg pain while preparing for a state gymnastics competition. “I felt a pain in my knee, but I didn’t tell my mother until afterwards because I wanted to compete,” says Virginia.
What she didn’t realize at the time was that her strength and perseverance through the pain would serve her well over the next few years, for a completely different reason.
After explaining the pain during a doctor’s visit, her primary care provider referred her to a local hospital to make sure nothi...
Source: Thrive, Children's Hospital Boston - July 16, 2013 Category: Pediatrics Authors: Andrea Mooney Tags: All posts Cancer Diseases & conditions Orthopedics Boston Children’s Hospital’s Bone Program osteosarcoma our patients' stories rotationplasty treatment for osteosarcoma Source Type: news
FDG-PET, DWI-MRI help predict osteosarcoma chemo response
Combining FDG-PET/CT and diffusion-weighed MRI (DWI-MRI) may be useful for (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 11, 2013 Category: Radiology Source Type: news
Fluorescent Biosensors for the Detection of HMGB1 Release
During necrosis and following some instances of apoptosis (in particular in the absence of a proficient phagocytic system), the nonhistone chromatin component high-mobility group box 1 (HMGB1) is released in the extracellular space. In vivo, extracellular HMGB1 can bind Toll-like receptor 4 on the surface of dendritic cells, de facto operating as a danger-associated molecular pattern and alarming the organism to the presence of stressful conditions. Recent results indicate that the release of HMGB1 is one of the key features for cell death to be perceived as immunogenic, i.e., to be capable of triggering a cognate immune r...
Source: Springer protocols feed by Cell Biology - June 5, 2013 Category: Cytology Source Type: news
Age, Gender Linked to Osteosarcoma OutcomesAge, Gender Linked to Osteosarcoma Outcomes
Age and gender may affect the way chemotherapy treats osteosarcoma, according to a large meta-analysis. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 27, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
"Clouds" singer known for viral hit dies from osteosarcoma
Minnesota teen Zach Sobiech became a YouTube sensation with his catchy song "Clouds" (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 21, 2013 Category: Consumer Health News Source Type: news
Celebs respond to dying teen's viral video
When he was 14, Zach was diagnosed with osteosarcoma, a type of bone cancer that mostly strikes children. His prognosis wasn't great. Last May, with no more treatment options, he was given just a year to live. (Source: WDSU.com - Health)
Source: WDSU.com - Health - May 9, 2013 Category: Consumer Health News Source Type: news
Grant funds research to study new treatments for osteosarcoma
Dr. Meenakshi Hegde, a researcher and instructor of pediatrics at Baylor College of Medicine, received a $100,000 grant from CureSearch for Children's Cancer to study how the immune system can be harnessed to develop new pediatric cancer treatments, particularly focused on osteosarcoma. (Source: Baylor College of Medicine News)
Source: Baylor College of Medicine News - May 2, 2013 Category: Universities & Medical Training Source Type: news
In Pediatric Bone Cancer, K9 Osteosarcoma Samples Identify Drivers Of Metastasis
Human osteosarcoma samples are hard to come by, making the disease difficult to study. However, K9 bone cancer is genetically indistinguishable from the human form of the disease, and over 10,000 canine patients develop the disease every year. Research from the University of Colorado Cancer Center and the Colorado State University Flint Animal Cancer Center presented at the AACR Annual Meeting 2013 used easily available K9 osteosarcoma samples to discover a novel protein that governs metastasis and chemoresistance in pediatric osteosarcoma... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 11, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Array Comparative Genomic Hybridization in Osteosarcoma
Osteosarcoma, the most frequent primary bone tumor, is a malignant mesenchymal sarcoma with a peak incidence in young children and adolescents. Left untreated, it progresses relentlessly to local and systemic disease, ultimately leading to death within months. Genomically, osteosarcomas are aneuploid with chaotic karyotypes, lacking the pathognomonic genetic rearrangements characteristic of most sarcomas. The familial genetics of osteosarcoma helped in elucidating some of the etiological molecular disruptions, such as the tumor suppressor genes RB1 in retinoblastoma and TP53 in Li–Fraumeni, and RECQL4 involved in DNA...
Source: Springer protocols feed by Genetics/Genomics - February 15, 2013 Category: Genetics & Stem Cells Source Type: news
Chromophobe Renal Cell Carcinoma with Osteosarcoma Differentiation
We present a 6th case of sarcomatoid chromophobe renal cell carcinoma, which had an osteosarcoma differentiation component. However, the correlation between the presence of heterologous elements and prognosis is unknown because of the rarity of this phenomenon.04/24/2012 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - April 26, 2012 Category: Cancer & Oncology Source Type: news
