How Common Are Bone Spurs in Young Athletes?
Discussion The terminology of abnormal calcification of soft tissues and uses of the terms is often muddied. Especially as the causes may be similar and multiple adjacent tissues may be involved. An exostosis is an abnormal proliferation of bone from the joint. They can appear in various forms and in many locations. An osteophyte is also known as a bone spur and is type of exostosis. Osteophytes are thought to be periosteal or synovial mesenchymal stems cells that become calcified. They usually have a more narrow or pointed projection from the joint. Osteophytes are a very common feature of osteoarthritis. Enthesophytes a...
Source: PediatricEducation.org - November 30, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What Causes Joint Pain?
DiscussionMusculoskeletal problems are common problems in pediatric practice with up to 15% of acute care visits being for this problem. Joint pain is a common concern for families but the differential diagnosis is extensive and needs thoughtful consideration. History is a key to discerning the potential diagnosis but also in guiding the physical examination and laboratory examination. Family history especially for systemic diseases should be considered. On physical examination all joints should be examined include sacroiliac and temporomandibular joints. Is this arthritis or arthralgia? Distinction between inflammatory...
Source: PediatricEducation.org - October 26, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

New osteosarcoma treatment receives rare pediatric disease designation from the FDA
(Medical University of South Carolina) Innova Therapeutics Inc. recently announced that the U.S. Food and Drug Administration has granted rare pediatric disease designation for IVT-8086 for the treatment of osteosarcoma. MUSC Hollings Cancer Center researcher Nancy Klauber-DeMore, M.D., was instrumental in the development of the research that led to the therapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 2, 2020 Category: Cancer & Oncology Source Type: news

Malignant cancer diagnosed in a dinosaur for the first time
(Royal Ontario Museum) A collaboration led by the Royal Ontario Museum (ROM) and McMaster University has led to the discovery and diagnosis of an aggressive malignant bone cancer -- an osteosarcoma -- for the first time ever in a dinosaur. No malignant cancers (tumours that can spread throughout the body and have severe health implications) have ever been documented in dinosaurs previously. The paper was published in The Lancet Oncology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 3, 2020 Category: Cancer & Oncology Source Type: news

MU advances chemotherapy-free treatment for cancer in animals and humans
(University of Missouri-Columbia) Osteosarcoma, a common bone cancer in dogs, affects more than 10,000 dogs in the US each year. While chemotherapy is generally effective at killing some of the cancer cells, the numerous side effects can be painful and often a subset of cancer cells exist that are resistant to chemotherapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 17, 2020 Category: Cancer & Oncology Source Type: news

Journal of Dental Research study: Fluoridation is not associated with increase in osteosarcoma
(International& American Associations for Dental Research) The Journal of Dental Research published today the results of a study that demonstrated that community water fluoridation is not associated with increased risk of osteosarcoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 12, 2020 Category: International Medicine & Public Health Source Type: news

NIH study provides genetic insights into osteosarcoma in children
Osteosarcoma is the most common cancerous bone tumor of children and adolescents. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - March 19, 2020 Category: American Health Source Type: news

NIH study provides genetic insights into osteosarcoma in children
(NIH/National Cancer Institute) A study by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, offers new insight into genetic alterations associated with osteosarcoma, the most common cancerous bone tumor of children and adolescents. The researchers found that more people with osteosarcoma carry harmful, or likely harmful, variants in known cancer-susceptibility genes than people without osteosarcoma. This finding has implications for genetic testing of children with osteosarcoma, as well as their families. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 19, 2020 Category: Cancer & Oncology Source Type: news

Tumor Profiling Yields Insights Into Poor Osteosarcoma Response to Immunotherapy Tumor Profiling Yields Insights Into Poor Osteosarcoma Response to Immunotherapy
Multiple genetic and cellular factors contribute to osteosarcoma ' s poor response to immunotherapy, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 3, 2020 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Profiling of Osteosarcoma Demonstrates Why Immunotherapy is Ineffective
Researchers found that poor infiltration of the tumor by immune cells, low activity from available T-cells, a lack of immune-stimulating neoantigens, and multiple immune-suppressing pathways all combine to dampen responses to immunotherapy in this disease landscape. (Source: CancerNetwork)
Source: CancerNetwork - February 25, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Osteosarcoma profiling reveals why immunotherapy remains ineffective
(University of Texas M. D. Anderson Cancer Center) Comprehensive profiling of tumor samples taken from patients with osteosarcoma shows that multiple factors contribute to the traditionally poor responses observed from treatment with immune checkpoint inhibitors, according to new research from The University of Texas MD Anderson Cancer Center. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 21, 2020 Category: Cancer & Oncology Source Type: news

Schoolgirl, nine, beat bone cancer after doctors amputated and reattached her leg BACKWARDS
Amelia Eldred, nine, from Tamworth, Staffordshire, was diagnosed with osteosarcoma, a common type of bone cancer, in August 2017. (Source: the Mail online | Health)
Source: the Mail online | Health - January 16, 2020 Category: Consumer Health News Source Type: news

Jack Savoretti messages cancer girl Anna Drysdale
Anna Drysdale, 8, contracted osteosarcoma at five and says getting the singer's message was "amazing". (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - December 2, 2019 Category: Consumer Health News Source Type: news

Boy, seven, who lost his leg due to cancer gets knee made using his FOOT
Austin Degnan, of Illinois, was diagnosed with osteosarcoma earlier this year, after complaining of a severe pain in his left leg. He underwent a surgical procedure called a rotationplasty. (Source: the Mail online | Health)
Source: the Mail online | Health - October 11, 2019 Category: Consumer Health News Source Type: news

Toddler with cancerous tumour in his knee has leg amputated and reattached BACKWARDS
Maxi Richards, three, of Tasmania, suddenly lost the ability to walk at 15 months old due to osteosarcoma. An operation, called a rotationplasty, removed the cancerous knee. (Source: the Mail online | Health)
Source: the Mail online | Health - July 23, 2019 Category: Consumer Health News Source Type: news