Supporting Evidence for Inactivity and Chronic Inflammation to be Important in Muscle Aging
It is well known that muscle function can be sustained into late life to a greater degree than most people manage. Much of what is presently considered by most people to be normal loss of strength and muscle mass with aging is the result of a combination of a lack of exercise combined with lifestyle choices, such as becoming overweight, that generate chronic inflammation. Researchers here illustrate the point in a study of gene expression changes that take place in muscle tissue with age and other factors. The researchers compared age versus exercise and inflammatory status. At least by looking at the number of changes, ch...
Source: Fight Aging! - March 6, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Higher Risk of Myocardial Infarction, Heart Failure, and Atrial Fibrillation Noted After Spinal Cord Injury
There are several factors which increase the risk of cardiovascular disease in survivors of spinal cord injury. They have a greater prevalence of obesity, dyslipidemia, metabolic syndrome and diabetes mellitus. Energy expenditure is lesser both due to lack of motor function and lack of opportunities to engage in physical activity. Autonomic dysfunction caused by spinal cord injury is associated with abnormalities in blood pressure, heart rate variability, arrhythmias and blunted cardiovascular response to exercise which can limit the capacity to perform physical activity [1].
A recent large study from Korea compared over 5...
Source: Cardiophile MD - February 27, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
The Gut Microbiome and Alzheimer's Disease
The balance of microbial populations making up the gut microbiome changes with age, both a loss of microbes generating beneficial metabolites and an increase in the number of inflammatory microbes. Separately from this harmful process, a number of studies have shown that that aged gut microbiome is distinctly different in patients with Alzheimer's disease, suggesting that there may be a meaningful contribution to disease onset and progression arising from the gut. The precise mechanisms involved have yet to be identified. While inflammation has an important role in Alzheimer's disease, the contribution of an Alzheimer's-li...
Source: Fight Aging! - February 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
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Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Going beyond the usual advice for eating healthy [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Join Francisco M. Torres, an interventional physiatrist. As the author of Dr. T’s Drop the Fat Diet: 12 Steps to Leaner You Forever, Dr. Torres shares invaluable findings from recent clinical studies, revealing which diets truly enhance longevity. Discover the secrets
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Going beyond the usual advice for eating healthy [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 25, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Obesity Source Type: blogs
More Visceral Fat, Greater Cognitive Decline in Later Life
Modern studies of the effects of excess body weight on long term health use measures, such as waist circumference or weight-adjusted waist index, that are more sensitive to visceral fat than subcutaneous fat. Excess visceral fat in the abdomen is actively harmful, in large part via causing an increased level of chronic inflammation via a variety of distinct mechanisms. Chronic inflammation accelerates the onset and drives the progression of neurodegenerative conditions, and thus might be expected to correlate with cognitive decline.
Some studies suggest that excessive obesity can lead to cognitive decline and deme...
Source: Fight Aging! - February 20, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Beyond Ozempic: Why one size doesn ’t fit all in weight loss
I grew up in Birmingham, Alabama, which is generally associated with a diet of all fried food. Prior to medical school, I thought many adults around me would eventually succumb to a diagnosis of hypertension and diabetes since they didn’t appear to think either was a big deal. However, my medical education quickly revealed that
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Beyond Ozempic: Why one size doesn’t fit all in weight loss originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 19, 2024 Category: General Medicine Authors: Janese S. Laster, MD Tags: Conditions Obesity Source Type: blogs
Fight Aging! Newsletter, February 19th 2024
This study aimed to explore the metabolic mechanisms and potential biomarkers associated with declining HGS among older adults. We recruited 15 age- and environment-matched inpatients (age, 77-90 years) with low or normal HGS. Liquid chromatography-mass spectrometry (LC-MS) and 16S ribosomal DNA (rDNA) gene sequencing were performed to analyze the metabolome of serum and stool samples and the gut microbiome composition of stool samples. Spearman's correlation analysis was used to identify the potential serum and fecal metabolites associated with HGS.
We assessed the levels of serum and fecal metabolites belonging to...
Source: Fight Aging! - February 18, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why the Low Weight Group Exhibits Worse Outcomes in Some Epidemiological Studies
In this study, we first explored the association between WC, WHtR, and WWI change patterns and multimorbidity. WC and WHtR are considered to be important anthropometric indicators of abdominal obesity. Previous studies have suggested that WC and WHtR can reflect body fat percentage accurately and play an important role in predicting some chronic diseases, such as cardiovascular disease and metabolic syndrome. The pathway may explain that abdominal obesity significantly increased plasma triglycerides, low density lipoproteins, and very low density lipoproteins, which have been shown to increase the risk of adverse outcomes ...
Source: Fight Aging! - February 16, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Abdominal Fat Correlates with Cognitive Decline
This study investigated the association between abdominal adiposity at baseline and change in cognitive function in community-dwelling older adults using longitudinal data collected separately for men and women over 10 years. Cognitive function was evaluated biennially using the Mini-Mental State Examination (MMSE) over 10 years. Waist circumference (WC) was measured at the naval level, and subcutaneous fat area (SFA) and visceral fat area (VFA) were assessed using baseline computed tomography scans.
This study included 873 older adults. In men, the groups with the highest levels of WC, SFA, and VFA exhibited a grea...
Source: Fight Aging! - February 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Let ’ s Think of Patient-Centered Care, Not Value-Based Care
This article explores some fundamental changes that could accompany this shift in terminology, revolutionizing how we handle data and patient interventions.
Engagement For Life
We know that maintaining health is an endeavor that takes years, even decades. A successful endeavor must survive the departure of clinicians who have built relationships with the patient, as well as the patient’s own geographic moves, changes of provider, and changes of insurance. Treatment recommendations should also be tailored to the psychology of each patient.
Is there a message in this exhortation for people working with data and healt...
Source: EMR and HIPAA - February 13, 2024 Category: Information Technology Authors: Andy Oram Tags: Analytics/Big Data C-Suite Leadership Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Interoperability Chronic Care Management Patient Centered Care Patients Society for Participatory Medic Source Type: blogs
Patient Advocates Argue Exercising Bayh-Dole " March-In " Rights Reasonable to Ensure Ongoing Supply of an Insulin Novo Nordisk Intends to Discontinue
Back in 2016 (when President Obama was still in office), the trade group known as the Pharmaceutical Research and Manufacturers of America (better known by the acronym PhRMA) claimed in an organization-published white paper (seehttps://web.archive.org/web/20161022175500/https://phrma.org/sites/default/files/pdf/bayh-dole-act-white-paper-summary.pdf for an archived copy of that paper from PhRMA; note that it has since been removed from PhRMA ' s website, hence I found a copy on the Internet Archive) that championed the Bayh-Dole Act of 1980. Understand that what PhRMA really wants to prevent a particular provision...
Source: Scott's Web Log - February 11, 2024 Category: Endocrinology Tags: march-in rights 2024 Alliance to Protect Insulin Choice APIC Bayh-Dole insulin detemir Levemir Novo Nordisk Source Type: blogs
Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people.
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Greater Individual Wealth Correlates with Longer Life Expectancy
https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/
Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Who to Blame for Health Costs: The Poisoned Chalice of “ Moral Hazard ”
By JEFF GOLDSMITH
How the Search for Perfect Markets has Damaged Health Policy
Sometimes ideas in healthcare are so powerful that they haunt us for generations even though their link to the real world we all live in is tenuous. The idea of “moral hazard” is one of these ideas. In 1963, future Nobel Laureate economist Kenneth Arrow wrote an influential essay about the applicability of market principles to medicine entitled “Uncertainty and the Welfare Economics of Medical Care”.
One problem Arrow mentioned in this essay was “moral hazard”- the enhancement of demand for something people us...
Source: The Health Care Blog - February 8, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Health Care Costs Jeff Goldsmith Kenneth Arrow Medicare Moral Hazard Source Type: blogs
