Fight Aging! Newsletter, November 13th 2023
This study investigated the correlation among muscle strength, working memory (WM), and cortical hemodynamics during the N-back task of memory performance, and further explored whether cortical hemodynamics during N-back task mediated the relationship between muscle strength and WM performance. We observed that muscle strength (particularly grip strength) predicted WM of older adults in this cross-sectional study, which validated our hypothesis and expanded on previous research findings. Studies demonstrated that grip strength predicted executive function decline in patients with mild cognitive impairment. Other cross-sect...
Source: Fight Aging! - November 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What we have to gain from weight loss drugs
Twenty years ago, the headlines were grim. It was common for studies to warn: “Rising childhood obesity will decrease life expectancy.” In large part, those predictions came true. The rise in obesity – both in children and adults – has correlated to a catastrophic rise in chronic disease that continues to affect life expectancy, cost
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What we have to gain from weight loss drugs originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 9, 2023 Category: General Medicine Authors: Hoag Memorial Hospital Presbyterian Tags: Conditions Endocrinology Source Type: blogs
Provoking Greater Stem Cell Activity to Reverse Cartilage Loss in Osteoarthritis
Osteoarthritis is a degenerative joint disease characterized by loss of cartilage and associated bone tissue. It is a major, widespread issue in old age. A promising study in mice here suggests that osteoarthritis might be reversed via suitable manipulation of stem cell and progenitor cell populations capable of producing cartilage regrowth. In this model, the known contributing factors, such as chronic inflammation in and around joint tissues, are contributing factors because they suppress the activity of the small population of cells responsible for maintenance of cartilage.
Osteoarthritis is the degeneration of...
Source: Fight Aging! - November 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing the Role of Cellular Senescence in Metabolic Disease
Senescent cells accumulate with age throughout the body. In youth the immune system promptly removes senescent cells, but this clearance slows with advancing age, leading to a growing population of lingering senescent cells. Senescent cells cease replicating and devote their efforts to the production of pro-growth, pro-inflammatory signals that become disruptive to tissue structure and function. Thus a population of senescent cells acts to actively maintain a degraded state of tissue, and their removal is immediately beneficial. Mouse studies show compelling, rapid reversals of age-related disease and extended life span re...
Source: Fight Aging! - November 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 6th 2023
This study aimed to gather valuable insights from pharmaceutical experts and healthcare practitioners regarding the potential and challenges of translating senolytic drugs for treatment of vascular aging-related disorders. This study employed a qualitative approach by conducting in-depth interviews with healthcare practitioners and pharmaceutical experts. Participants were selected through purposeful sampling. Thematic analysis was used to identify themes from the interview transcripts. A total of six individuals were interviewed, with three being pharmaceutical experts and the remaining three healthcare practitioners.
...
Source: Fight Aging! - November 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The critical link between America ’ s obesity epidemic and the liver
Obesity has undeniably become the top health issue of our time, with its prevalence and impact on our bodies making headlines across health care and popular media. This isn’t merely a matter of carrying extra pounds; it’s about the multitude of serious health complications that come in its wake. The conversation around obesity often gravitates
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The critical link between America’s obesity epidemic and the liver originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 3, 2023 Category: General Medicine Authors: Darryn Potosky, MD Tags: Conditions Gastroenterology Source Type: blogs
Overcoming health challenges: one patient ’ s story
The patient was a typical one in my primary care practice, and for those of you in my field, one familiar to you as well. Jim, as we will call him, was a middle-aged, obese male with a history of hypertension, hyperlipidemia, and diabetes, whose most concerning medical problem was his long history of noncompliance.
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Overcoming health challenges: one patient’s story originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 2, 2023 Category: General Medicine Authors: Becky Purkaple, MD Tags: Conditions Diabetes Primary Care Source Type: blogs
Reviewing the Role of Insulin in Aging
The relationship between insulin metabolism and aging is one of the most studied areas of the field, with decades of researchers putting in time to deepen the understanding of the web of interactions surrounding insulin. Yet this has failed to lead to any practical outcome when it comes to slowing or reversing aging. Researchers now have an incrementally better idea as to why obesity, metabolic syndrome, and type 2 diabetes shorten life and worsen health, but that was well understood to be the case well prior to the advent of modern biotechnology.
Experimental studies in animal models of aging such as nematodes, f...
Source: Fight Aging! - October 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
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Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Producing Alzheimer's Symptoms in Rats via a Transplanted Gut Microbiome
The gut microbiome changes with age, the relative population sizes of the many distinct microbial species altering to provoke chronic inflammation and potentially other, more complex issues driven by changes in the production of beneficial and harmful metabolites. With the advent of ways to cheaply assess the contents of the gut microbiome, researchers are finding that a number of age-related conditions appear characterized by dysbiosis, growth in the population of specific harmful microbial species. One of those conditions is Alzheimer's disease, which has a puzzling incidence that doesn't track well with the well establi...
Source: Fight Aging! - October 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Serum Galectin-3 Correlates with Frailty Risk
In this study, we aimed to address the change of Gal-3 levels in human whole blood with frailty. We performed serum biochemical and peripheral blood mononuclear cells (PBMC) microarray analyses in humans to determine the secretory phenotype characteristics of frailty. Furthermore, we used the frail mouse model to study the significantly altered behavioral phenotype and associated secreted Gal-3 levels in blood samples to reveal the Gal-3-dependent inflammatory dysregulation of frailty. (Source: Fight Aging!)
Source: Fight Aging! - October 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Spandex dilemma: Does size still matter?
In today’s fashion landscape, one may wonder if size truly matters anymore. With the prevalence of spandex in clothing, determining one’s actual size has become a challenging feat. The question arises: what role does spandex play in the ongoing obesity crisis? Does it hinder our ability to make informed choices about our weight and health?
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The Spandex dilemma: Does size still matter? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 22, 2023 Category: General Medicine Authors: Janet L. Cray Tags: Conditions KevinMD Obesity Source Type: blogs
Mindfulness Based Interventions For Healthcare Professionals
Healthcare professionals frequently experience stress and burnout in their work environment. Unaddressed, such stress and burnout sometimes lead to physical and mental health problems, including anxiety, depression, diabetes, fatigue, heart disease, hypertension, insomnia and obesity Burnout amongst HCPs has also been associated with reduced job satisfaction and negative patient outcomes, like reduced patient satisfaction and increased work errors.
There is a growing evidence suggesting that mindfulness-based interventions (MBIs) can help decrease stress and burnout experienced amongst HCPs, increasing job satisfaction ...
Source: The Orthopedic Logbook - October 21, 2023 Category: Orthopaedics Authors: Remo Aguilar Tags: Focus Habits burnout health workers burnout meditation mindfulness minfulness based intervention stress stress reduction Source Type: blogs
The Future of Digital Health: How UX Design is Shaping the Industry
By PARV SONDHI
As the digital health world continues to expand, more and more people are turning to apps to manage everything from diabetes and obesity to depression and anxiety. People rely on these apps for their physical and mental health, so it’s crucial that product developers ensure a safe, effective, and engaging experience for them. Healthcare experts agree.
A team of researchers and health system leaders recently introduced a new framework called “Evidence DEFINED” for evaluating digital health products. This framework offers hospitals, payers, and trade organizations a precise set of guidelines to as...
Source: The Health Care Blog - October 20, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Design digital health UX vida health Source Type: blogs
Ozempic Seems To Be Getting A Lot Of Attention. Care Is Required With On-Line Sales And Marketing At Least!
Fads are a
commonly seen manifestation in the health sector.
It could be
argued to latest biggie is semaglutide (Ozempic). The drug was introduced as a
treatment for Type 2 diabetes but it is the powerful weigh-loss effects that
have been noticed in the overweight rich world – which now has a shortage and which has the drug selling in such quantities that it is having a real impact on the Danish (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - October 17, 2023 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
