Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia
This article was originally published on The Conversation.
News in Context:
Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging
What are cognitive abilities and how to boost them?
The post Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - December 14, 2023 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health Alzheimer’s biological Brain-Fitness cognition cognitive engagement cognitive-abilities cognitive-reserve dementia depression exercise inflammation lifestyle neuroplasticity optimize cognition Stress Source Type: blogs
Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
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Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
OMI in a pediatric patient? Teenagers do get acute coronary occlusion, so don't automatically dismiss the idea.
Acute coronary syndrome in a pediatric patient?Written by Kirsten Morrissey, MD with edits by Bracey,
Grauer, Meyers, and Smith An older teen was transferred from an outside hospital
with elevated serum troponin and and ECG demonstrating ST elevations. The patient was obese and had a medical history of only recurrent tonsillitis status post tonsillectomy and adenoidectomy but was otherwise healthy and fully vaccinated. He reported 1.5 days of chest pain that started as substernal and crushing in nature awakening him from sleep and occasionally traveling to right side of neck. The pain ...
Source: Dr. Smith's ECG Blog - December 5, 2023 Category: Cardiology Authors: Bracey Source Type: blogs
A Longevity Industry Feature in Biopharma Dealmakers: Repair Biotechnologies, Deciduous Therapeutics, and More
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose. (Source: Fight Aging!)
Source: Fight Aging! - December 4, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Impact of Healthcare Professional ’ s Sports and Fitness Activities on Personal and Professional Life
In 2010, a third of the world’s population was considered physically inactive. Back then it was estimated that approximately 5 million deaths were attributable to physical inactivity, making it the fourth leading cause of mortality worldwide.
To address this global issue, a whole society approach consisting of “policy and environmental changes” to make physical activity “an easier choice for leisure and transportation purposes”. An example of this is the recent proliferation of bike lanes in many of our cities. We also need to adjust our social and cultural norms to promote physical activit...
Source: The Orthopedic Logbook - December 2, 2023 Category: Orthopaedics Authors: Remo Aguilar Tags: Habits Health fitness physical activity physical inactivity Physician Health sedentary Sports Source Type: blogs
The Effects of Diet on Life Expectancy
It is somewhat interesting to see a careful analysis of diet and life expectancy, using the sizable UK Biobank population, that does not contain any of the words "calorie", "weight", or "obesity". The effects of calorie intake on health over the long-term are sizable, even if we focus only on mechanisms associated with the gain of weight. Visceral fat is metabolically active, generates an increased burden of senescent cells, and contributes to the chronic inflammation of aging via a range of different mechanisms.
Thus one would assume that buried underneath this set of data on what it is that people eat is a more re...
Source: Fight Aging! - December 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Visceral Fat Increases Brain Inflammation and Amyloid Aggregation
The correlation between being overweight and risk of developing Alzheimer's disease is nowhere near as strong as, say, between being overweight and risk of developing type 2 diabetes. Given the evidence for chronic inflammation to be important in the development of Alzheimer's disease, and the many ways in which excess visceral fat tissue promotes chronic inflammation, it is somewhat puzzling that Alzheimer's isn't more of a lifestyle disease, similar to the way in which type 2 diabetes derives from lifestyle choices. That said, there is a contribution to Alzheimer's risk, and carrying excess weight is unwise, for this and...
Source: Fight Aging! - November 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Novel Mitophagy Inducing Compound
A sizable fraction of research aimed at treating aging involves screening natural compounds in search of those that can modestly slow aging in short-lived animal models. This is because the economics of developing such a compound into a drug or supplement are well understood by investors, and because it dovetails well with the scientific goal of increased understanding of how aging progresses at the level of cellular biochemistry, rather than because it is going to make a big difference for patients. If sizable gains in healthy life span were the driving incentive, the field would look very different, and the emphasis woul...
Source: Fight Aging! - November 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Semaglutide Use Reduces Heart Attack Incidence in Obese Individuals
Some interesting numbers for the effects of weight loss in obese individuals on risk of age-related disease arise from the use of semaglutide in clinical trials. In the study noted here, treated individuals lost 9% of body weight versus 1% for the placebo arm. The outcome of that is at least as good as the use of statins when it comes to effects on cardiovascular disease. The lesson to take away from this is likely that being overweight is more harmful than most people like to think that it is. Existing data is certainly supportive of that conclusion. Excess visceral fat tissue has been shown to lead to a shorter life expe...
Source: Fight Aging! - November 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Zealous for Wellness: How to Replace Hype with Data
This article begins a series that looks at useful measures of health and how the companies that promote wellness programs demonstrate their success. We’ll see measurements of objective outcomes, patient-reported outcomes, and what payers look for when they can’t get direct evidence of improvements in wellness.
You’ll note, as we survey the wellness solutions and measurements used, that the leading organizations in this space are payers, not clinicians. I’m sure that doctors and nurse practitioners truly care for the overall happiness and wellbeing of their patients. But the institutions aren’t...
Source: EMR and HIPAA - November 14, 2023 Category: Information Technology Authors: Andy Oram Tags: AI/Machine Learning Ambulatory Analytics/Big Data Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System LTPAC Telemedicine and Remote Monitoring ACOs Avanade Christiana Voelker Cli Source Type: blogs
Lifestyle Choices Do Slow Aging, Just Not as Much as We'd Like
In recent years, a number of epidemiological studies have demonstrated that people with healthier lifestyles tend to live longer, at least within the bounds of later life from 60 to 100. That in turn is reflected by a lesser burden of various forms of cell and tissue damage, such as the accumulation of senescent cells. This isn't a controversial statement, though there is room enough to argue for an eternity over just how large the effect of any specific choice might be, how that effect size varies between populations, how different choices combine, and so forth. Then on top of all of this, the question of what happens and...
Source: Fight Aging! - November 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Bonus Features – November 12, 2023 – 93% of clinicians use RPM in cardiac care rehab, telehealth flexibilities remain in place until the end of 2024, plus 25 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
The 2024 Medicare Physician Fee Schedule continues many telehealth flexibilities first adopted during the public health emergency, such as an expanded scope of originating sites an expanded definition of qualified practiti...
Source: EMR and HIPAA - November 12, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT 1upHealth Apollo ApolloMed Cedar Cognoa CPSI Deloitte Technology Fast 500™ emtelligent Freshpaint Healthcare IT Today Bonus Features HITRUST Certification Hona Innovaccer Inovalon Jim Hundemer Jim Sparks K Source Type: blogs
