Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wearable Takes Blood-Free Stress Hormone Samples
Researchers at the University of Birmingham in the UK have developed a wearable that can assist in keeping track of stress hormone levels in the body over time. Disregulated stress hormones can play a role in various disease states, from heart disease to depression. However, until now, researchers had to perform blood draws to measure stress hormone levels, meaning that they could obtain just one snapshot in time of hormone levels or repeated blood draws over time, neither of which are ideal. This latest technology, called U-RHYTHM, acts as a wearable sampling device, and can obtain stress hormone samples from beneath the ...
Source: Medgadget - July 14, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine stress hormone unibirmingham Source Type: blogs
Primary Hypertension: The Unseen Risk For Healthy People
Conclusion
In conclusion, even the healthiest individuals can develop primary hypertension, a condition that affects a significant portion of the U.S. adult population. With its roots often hidden in our genetic makeup and influenced by various lifestyle factors, hypertension can quietly disrupt our wellbeing, earning its nickname as the “silent killer.”
Real-life experiences, such as Martin Cassels’, highlight that maintaining an active, healthy lifestyle doesn’t render one immune to this condition. However, it underscores the importance of regular health check-ups and the value of a second o...
Source: The EMT Spot - July 13, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
The Influence of Chronic Inflammation on the Hallmarks of Aging
Chronic inflammation is a feature of aging, a continual activation of the immune response without any triggering injury or infection. Many different mechanisms contribute to this state of unresolved inflammatory signaling: the accumulation of senescent cells and the senescence-associated secretory phenotype (SASP); mitochondrial dysfunction leading to mislocalized mitochondrial DNA that triggers an innate immune reaction; signaling from visceral fat cells in those who are overweight; changes in the gut microbiome and intestinal barrier that allow microbes and microbial metabolites to provoke the immune system; and so on an...
Source: Fight Aging! - July 11, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Uncovering the truth about genetic mutations and weight loss
“I do not feel full even after I eat” is what I heard from so many of my patients. Even after bariatric surgery, this feeling of fullness would go away initially but then it would come back, and they found themselves again overindulging. Why does this happen? Brain studies have shown that obesity impairs the
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Uncovering the truth about genetic mutations and weight loss originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 10, 2023 Category: General Medicine Authors: Franchell Hamilton, MD Tags: Conditions Obesity Source Type: blogs
Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options.
The Aging of the Enteric Nervous System
https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/
The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome ...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Medicare Advantage Plans Can Leverage Virtual Cardiometabolic Care
BY RICHARD FRANK
By relying on virtual cardiometabolic solutions for continuous care, Medicare Advantage can produce better outcomes, curb costs, enhance member satisfaction — and improve Star ratings in the process.
By Richard Frank, MD, Chief Medical Officer Vida Health
Medicare Advantage is a hot market. Enrollment is steadily climbing and Medicare Advantage (MA) members now make up half the Medicare population. Though members keep rolling in, competition among MA plans is tight and turnover remains high. Nearly 16% of MA members switch plans at least once during their first year, while over a third end up sw...
Source: The Health Care Blog - July 5, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Cariometabolic conditions Medicare Advantage Richard Frank Source Type: blogs
Breaking Down Methionine as an Alternative to a Low Methionine Diet
In conclusion, the present study provides evidence that restricting methionine by either a low-methionine diet or E. coli JM109-rMETase has clinical potential to treat old-age-induced obesity.
Link: https://doi.org/10.18632/aging.204783 (Source: Fight Aging!)
Source: Fight Aging! - July 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Navitus 2022 Drug Trend Report
Its been many years since I posted news of a PBM Drug Trend Report. Once upon a time, PBM drug trend reports contained lots of interesting information. However, over time (in 2021, for example, when reports from the preceding year were published), CVS Caremark published only a bare-bones summary, while Prime Therapeutics, MedImpact, and other large PBMs all completelystopped publishing drug trend reports. The reason is basically because its becoming harder and harder for PBMs to present themselves as saving money when the biggest PBMs aren ' t saving any entities any money on prescription drugs anymore (I...
Source: Scott's Web Log - July 5, 2023 Category: Endocrinology Tags: 2022 2023 Drug Trend Report Navitus Navitus Health Solutions PBM Source Type: blogs
A Common Drink That Doubles Weight Loss
Researchers have found that around 50 percent of the obese are deficient in a mineral contained in this drink. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - July 4, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
It is time for the FDA to re-evaluate metrics for weight loss drugs
Between 2013 and 2016, 49.1 percent of U.S. adults surveyed had attempted to lose weight within the last 12 months. Weight loss medications have reached the public eye in popular culture and practice. To be considered effective in a clinical trial by the FDA, the drug candidate must demonstrate a statistically significant difference in mean
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It is time for the FDA to re-evaluate metrics for weight loss drugs originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 4, 2023 Category: General Medicine Authors: Tatum R. Dam, Diana A. Hla, Aditya Narayan, and Ank A. AgarwalTags: Meds Obesity Source Type: blogs
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Metabolic Disorders Increase the Burden of Cellular Senescence
Why do patients with metabolic disorders such as obesity and type 2 diabetes exhibit what appears to be an accelerated progression of aging, such as increased risk of disease, shorter life expectancy, and so forth? One increasingly well established candidate mechanism is the presence of a greater burden of senescent cells, these cells generating chronic inflammation and harmful alterations to the behavior of other cells via their secretions. Senolytic therapies to clear these senescent cells may prove to be a first step towards decoupling obesity from the consequences of obesity, but there are numerous other ways in which ...
Source: Fight Aging! - June 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Popular Weight Loss Drug That Also Fight Cancer
A popular drug that treats obesity may also help to destroy cancer cells. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - June 19, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Cancer Source Type: blogs
What happens when Rx price bubbles (such as on insulin) burst?
In the first half of 2023, Americans witnessed evidence of a rather fundamental shift in the manner pharma had traditionally opted to commercialize selected prescription drugs. Specifically, in March 2023,Lilly,Novo Nordisk andSanofi each announced they planned to slash insulin list prices for insulin. To do so, they would disintermediate PBMs from the transaction and " opt out " of the PBM commercialization channel.The decision wasn ' t really all that difficult; for years branded insulin-makers had been complaining that PBMs and other drug distribution system entities had been gobbling up an ever-larger share of their re...
Source: Scott's Web Log - June 19, 2023 Category: Endocrinology Tags: 2023 Source Type: blogs
