What's new in midwifery - 24th February 2023 - research
Some things you may want to know about:Effectiveness evaluation of anantenatal care intervention addressing disparities to improve perinatal outcomes in Denmark: A nationwide register-based analysis of a cluster randomised controlled trial (MAMAACT), Meperidine compared with nitrous oxide forintrapartum pain relief in multiparous patients: a randomized controlled trial.Nurses ' and midwives ' perceptions and strategies to cope withperinatal death situations: A systematic literature review.Vitamin D supplementation for the outcomes of patients with gestational diabetes mellitus and neonates: a meta-analysis and systema...
Source: Browsing - February 24, 2023 Category: Databases & Libraries Tags: midwifery Source Type: blogs
A Discussion of Mitochondrially Derived Peptide MOTS-c
A number of mitochondrially derived peptides are thought to have positive effects on cell function, though as for most of the approaches of this nature, it is unclear that it is any better than a structured exercise program. One of the better studied of these peptides is MOTS-c, which is itself upregulated by exercise - arguably one of a number of known exercise mimetics. Delivering signal molecules that are normally upregulated by exercise should in principle recapture some of the beneficial effects of exercise, but so far this line of development has yet to much improve on exercise itself.
Mitochondria are organ...
Source: Fight Aging! - February 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The middle road to childhood obesity treatment: Empowering kids with healthy habits
The new American Academy of Pediatrics guidelines for childhood obesity have shifted from a “watchful waiting” method to “early and aggressive treatment.” Coverage of the guidelines in the Washington Post, the New York Times, and other reputable news outlets have readily accepted this new depiction of childhood obesity as a disorder in need of immediate,
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The middle road to childhood obesity treatment: Empowering kids with healthy habits originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 21, 2023 Category: General Medicine Authors: Paul Porras, MD Tags: Conditions Pediatrics Source Type: blogs
Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Business of Diabetes: Dexcom Spends Big on Super Bowl Ad to Hype New G7 Claiming " Feels Like Magic " ; But the Ad Isn't Magic
This month was the U.S. NFL ' s Super Bowl #57; the two teams which played one another were the Philadelphia Eagles and the Kansas City (Missouri) Chiefs, and the Kansas City Chiefs were the winners in a close game throughout. For a moment, let ' s just overlook that Kansas City ' s team name is rooted in the same racism against indigenous native Americans (after all, the team ' s logo is an arrowhead, which was created by native Americans) the same view ultimately forced the old Washington Redskins to change the team name to the Washington Commanders), and let ' s instead focus on this year ' s game advertising. But Misso...
Source: Scott's Web Log - February 18, 2023 Category: Endocrinology Tags: Business of Diabetes 2023 Abbott Advertising business strategy CGM CGMS Dexcom Freestyle Libre Super Bowl Source Type: blogs
Dexcom Spends Big on Super Bowl Ad to Hype New G7 Claiming " Feels Like Magic " ; But Formulary Exclusions Aren't Magic
This month was the U.S. NFL ' s Super Bowl #57; the two teams which played one another were the Philadelphia Eagles and the Kansas City (Missouri) Chiefs, and the Kansas City Chiefs were the winners in a close game throughout. For a moment, let ' s just overlook that Kansas City ' s team name is rooted in the same racism against indigenous native Americans (after all, the team ' s logo is an arrowhead, which was created by native Americans) the same view ultimately forced the old Washington Redskins to change the team name to the Washington Commanders), and let ' s instead focus on this year ' s game advertising. Whil...
Source: Scott's Web Log - February 18, 2023 Category: Endocrinology Tags: Business of Diabetes 2023 Abbott Advertising business strategy CGM CGMS Dexcom Freestyle Libre Super Bowl Source Type: blogs
Epigenetic Clock Data from the CALERIE Trial of Calorie Restriction
The practice of calorie restriction extends life notably in short-lived mammals, but not in long-lived mammals, despite the short-term benefits to health appearing quite similar in mice and humans. This may be because many of the beneficial shifts in metabolism triggered by a low calorie intake are already built in to long-lived species, as a part of the history of evolutionary change that led to those species becoming long-lived. Since calorie restriction alters near every aspect of cellular biochemistry, coming up with a comprehensive understanding of the important mechanisms has been a slow process, never mind how those...
Source: Fight Aging! - February 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Acoustic Stimulation for Insomnia
Researchers at Wake Forest University School of Medicine have tested a closed-loop acoustic stimulation neurotechnology in its ability to treat insomnia. The device in question has been developed by Cereset, a medtech company headquartered in Arizona. Insomnia is not just unpleasant, but can have significant long-term health consequences, including an increased risk of cardiovascular disease, obesity, and diabetes. This technology works by monitoring brain waves through scalp sensors and then translating these waves into auditory tones that are played back to the wearer through ear buds. The researchers describe the techno...
Source: Medgadget - February 15, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine insomnia WakeForest WeAreCereset Source Type: blogs
A Shabby Pop-Sci Article on the Minicircle Trial of Follistatin Gene Therapy
Minicircle is working towards the upregulation of follistatin, an inhibitor of myostatin and thus an interesting target for improved muscle growth and treatment of sarcopenia. Follistatin and myostatin are well studied genes in this context, and there are any number of animal studies, as well as human trials of various approaches to myostatin inhibition. As I have long said, follistatin and myostatin are probably the most compelling, least risky genes to start working on if interested in gene therapy development. There is a great deal of animal and human data to support this work.
It is always annoying to see shabbi...
Source: Fight Aging! - February 14, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
SIRT3 Upregulation as a Basis for Improving Mitochondrial Function in the Aging Brain
SIRT3 beneficially affects mitochondrial function, and its upregulation is a calorie restriction mimetic strategy, since it mediates some of the benefits resulting from a lowered calorie intake. Given this, there is some interest in this as a basis for treatments for neurodegenerative conditions, in which loss of mitochondrial function in the brain is thought to be an important contribution to pathology. Mitochondria are the power plants of the cell, and the brain requires a great deal of energy to operate. So far, efforts to improve mitochondrial function in aged tissues by targeting the expressed levels of specific prote...
Source: Fight Aging! - February 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed.
The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
This Antioxidant Supplement Leads To Weight Loss
Overweight people who took this antioxidant supplement managed to slim down without diet or exercise. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 11, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Weight Loss Source Type: blogs
How Fatty Liver Disease Affects The Brain (M)
One-quarter of the population has fatty liver disease, along with 80 percent of those who are morbidly obese. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 8, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Brain Health subscribers-only Source Type: blogs
Reviewing the Development of Senotherapeutics
Today's open access paper is a very readable tour of the present state of research and development of therapies targeting senescent cells, whether to destroy them or alter their function in favorable ways. In both cases the primary goal is to reduce the senescence-associated secretory phenotype (SASP), the pro-growth, pro-inflammatory signaling that contributes to degenerative aging as the number of senescent cells rises over the course of later life. It is hoped that clearance of senescent cells will produce a sizable positive impact for late life health, reducing chronic inflammation, slowing the onset of near all age-re...
Source: Fight Aging! - February 7, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Time Restricted Feeding as a Tool to Modulate the Gut Microbiome
The gut microbiome changes with age, the balance of microbial populations shifting to cause more inflammation and a lesser production of beneficial metabolites. To what degree can forms of fasting and time restricted feeding improve the aged gut microbiome? The authors of this paper seem optimistic, but more data is needed. Particularly, I'd want to see data in calorie restricted or intermittently fasted old rodents in direct comparison with the effects of fecal microbiota transplant from young animals. Obtaining human data for the same interventions should not be too challenging a prospect; it just requires the will and f...
Source: Fight Aging! - February 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
