Correction: SARS-CoV-2 Virologic Rebound With Nirmatrelvir-Ritonavir Therapy
Ann Intern Med. 2024 Feb 20. doi: 10.7326/L24-0045. Online ahead of print.NO ABSTRACTPMID:38373305 | DOI:10.7326/L24-0045 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - February 19, 2024 Category: Internal Medicine Source Type: research
Correction: SARS-CoV-2 Virologic Rebound With Nirmatrelvir-Ritonavir Therapy
Ann Intern Med. 2024 Feb 20. doi: 10.7326/L24-0045. Online ahead of print.NO ABSTRACTPMID:38373305 | DOI:10.7326/L24-0045 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - February 19, 2024 Category: Internal Medicine Source Type: research
Outcomes of Drug Interactions Between Antiretrovirals and Co-Medications, Including Over-the-Counter Drugs: A Real-World Study
ConclusionsFrequent unwanted outcomes resulting from DDIs between ARVs and OTC medications underscore the importance of integrating non-prescription drugs into medication reconciliation. The real-world data available throughwww.clinicalcasesDDIs.com serves as a valuable resource for assessing the clinical relevance of DDIs. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - February 19, 2024 Category: Infectious Diseases Source Type: research
The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear extinction in mice
The mechanisms behind a lack of efficient fear extinction in some individuals are unclear. Here, by employing a principal components analysis–based approach, we differentiated the mice into extinction-resistant and susceptible groups. We determined that elevated synapsin 2a (Syn2a) in the infralimbic cortex (IL) to basolateral amygdala (BLA) circuit disrupted presynaptic orchestration, leading to an excitatory/inhibitory imbalance in the BLA region and causing extinction resistance. Overexpression or silencing of Syn2a levels in IL neurons replicated or alleviated behavioral, electrophysiological, and biochemical phenoty...
Source: Journal of Clinical Investigation - February 15, 2024 Category: Biomedical Science Authors: Xi-Ya Shen, Juan Zhang, He-Zhou Huang, Shao-Dan Li, Ling Zhou, Shi-Ping Wu, Cheng Tang, Xian Huang, Zhi-Qiang Liu, Zi-Yuan Guo, Xiang Li, Heng-Ye Man, You-Ming Lu, Ling-Qiang Zhu, Dan Liu Source Type: research
The effectiveness of oral anti-SARS-CoV-2 agents in non-hospitalized COVID-19 patients with nonalcoholic fatty liver disease: a retrospective study
Conclusion: Novel oral antiviral agents are beneficial for treating COVID-19 in patients with nonalcoholic fatty liver disease. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 15, 2024 Category: Drugs & Pharmacology Source Type: research
Associations of nirmatrelvir-ritonavir treatment with death and clinical improvement in hospitalized patients with COVID-19 during the Omicron wave in Beijing, China: a multicentre, retrospective cohort study
CONCLUSION: Among hospitalized patients with COVID-19 during the Omicron wave in Beijing, China, the early initiation of nirmatrelvir-ritonavir was associated with clinical benefits of lowering mortality and improving clinical recovery.PMID:38354691 | PMC:PMC10868413 | DOI:10.1080/07853890.2024.2313062 (Source: Annals of Medicine)
Source: Annals of Medicine - February 14, 2024 Category: Internal Medicine Authors: Xiaobo Han Chenglong Li Xin Yuan Junchang Cui Zhihai Han Jiguang Meng Weiguo Zhao Fei Xie Kaifei Wang Yuhong Liu Guoxin Muo Na Xi Mengli Zheng Rentao Wang Kun Xiao Wei Chen Junchen Xiong Dahui Zhao Xinxin Zhang Xinjie Han Haibo Cheng Zhongkuo Yu Yinghan S Source Type: research
Phenytoin enzyme induction for management of supratherapeutic tacrolimus levels due to drug-drug interaction with nirmatrelvir/ritonavir: Case series and discussion
CONCLUSION: These observations demonstrate that metabolism induction using phenytoin may be a useful strategy in the setting of supratherapeutic tacrolimus levels resulting from concomitant administration with nirmatrelvir/ritonavir.PMID:38347740 | DOI:10.1093/ajhp/zxae032 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - February 13, 2024 Category: Drugs & Pharmacology Authors: Jennifer Marsh Angela T Logan Erin P Bilgili Lyndsey J Bowman Allyssa R Webb Source Type: research
Allograft function predicts mortality in kidney transplant recipients with severe COVID-19: a paradoxical risk factor
ConclusionsPre-infection allograft function is a good predictor of death in patients with severe COVID-19. Allograft function was improved after treatment for severe COVID-19, which was not observed in patients with non-severe COVID-19. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 13, 2024 Category: Allergy & Immunology Source Type: research
Retraction Note: High success rates for the use of sofosbuvir/ombitasvir/paritaprevir/ritonavir + ribavirin and sofosbuvir/simeprevir/daclatasvir + ribavirin in retreatment of chronic hepatitis C infection after unsuccessful sofosbuvir/daclatasvir therapy: a real-life experience
(Source: Archives of Virology)
Source: Archives of Virology - February 13, 2024 Category: Virology Source Type: research
Serum Lipid Profiles, Blood Glucose, and High-Sensitivity C-Reactive Protein Levels Among People Living with HIV Taking Dolutegravir and Ritonavir-Boosted Atazanavir-Based Antiretroviral Therapy at Jimma University Medical Center, Southwest Ethiopia, 2021
(Source: Therapeutics and Clinical Risk Management)
Source: Therapeutics and Clinical Risk Management - February 12, 2024 Category: Drugs & Pharmacology Tags: HIV/AIDS - Research and Palliative Care Source Type: research
Body weight and blood pressure changes on dolutegravir-, efavirenz- or atazanavir-based antiretroviral therapy in Zimbabwe: a longitudinal study
CONCLUSIONS: Among PLHIV starting ART or switching to a new regimen, DTG-based ART was associated with larger weight gains and a substantial increase in the prevalence of high blood pressure. Routine weight and blood pressure measurement and interventions to lower blood pressure could benefit PLHIV on DTG-based ART. Further studies are needed to elucidate the mechanisms and reversibility of these changes after discontinuation of DTG.PMID:38332525 | PMC:PMC10853595 | DOI:10.1002/jia2.26216 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 9, 2024 Category: Infectious Diseases Authors: Tinei Shamu Matthias Egger Tinashe Mudzviti Cleophas Chimbetete Justen Manasa Nanina Anderegg Source Type: research
