Acute Tacrolimus Toxicity Due to Paxlovid Successfully Managed with Phenytoin After Lung Transplantation
We present the case of a 68 year-old female, 7 years after lung transplant who developed significant tacrolimus toxicity following administration of Paxlovid (ritonavir-nirmaltrevir), a potent CYP3A4 inhibitor, and was successfully managed with phenytoin. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: C.J. White, S. Bailey, B. Murnion, M. Plit, Source Type: research
Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19
We present a case of paralytic ileus resulting from tacrolimus toxicity mediated by the use of nirmatrelvir/ritonavir in a patient with systemic lupus erythematosus (SLE). A 37-year-old female SLE patient was prescribed nirmatrelvir/ritonavir without discontinuing tacrolimus. She presented to the emergency room with symptoms of paralytic ileus including persistent abdominal pain, nausea, and vomiting, which were verified to be associated with tacrolimus toxicity. The blood concentration of tacrolimus was measured >30 ng/mL. Urgent medical intervention was initiated, while tacrolimus was withheld. The residual concentra...
Source: Frontiers in Pharmacology - March 27, 2024 Category: Drugs & Pharmacology Source Type: research
Clinical effectiveness of oral antiviral agents for treating non-hospitalized COVID-19 patients with chronic kidney disease
CONCLUSION: Oral antiviral agents could be associated with lower rates of all-cause hospitalization or death among non-hospitalized COVID-19 patients with CKD.PMID:38525673 | DOI:10.1080/14787210.2024.2334052 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - March 25, 2024 Category: Infectious Diseases Authors: Chia-Chen Chen Chi-Ya Huang Jheng-Yan Wu Mei-Yuan Liu Min-Hsiang Chuang Ting-Hui Liu Ya-Wen Tsai Wan-Hsuan Hsu Po-Yu Huang Ming-Hui Chen Su-Yen Liu Mei-Chuan Lee Kuo-Chuan Hung Chih-Cheng Lai I-Ning Yang Source Type: research
Antivirals for the treatment of mild and moderate COVID-19 in South Africa
S Afr Med J. 2023 Dec 4;113(12):33. doi: 10.7196/SAMJ.2023.v113i12.1066.ABSTRACTWhile the majority of COVID-19 cases in South Africa (SA) are mild, patients with severe COVID-19 requiring hospitalisation present with significant morbidity and mortality and place a substantial burden on healthcare services. Given the low vaccine uptake in SA and other low- and middle-income countries in sub-Saharan Africa, the high prevalence of comorbidities and limited healthcare system capacity, evidence-based interventions that reduce the risk of severe disease and death should be considered for implementation. Several antiviral classes...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: R Perumal V Naidoo S Govender T N Gengiah Source Type: research
Clinical effectiveness of oral antiviral agents for treating non-hospitalized COVID-19 patients with chronic kidney disease
CONCLUSION: Oral antiviral agents could be associated with lower rates of all-cause hospitalization or death among non-hospitalized COVID-19 patients with CKD.PMID:38525673 | DOI:10.1080/14787210.2024.2334052 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - March 25, 2024 Category: Infectious Diseases Authors: Chia-Chen Chen Chi-Ya Huang Jheng-Yan Wu Mei-Yuan Liu Min-Hsiang Chuang Ting-Hui Liu Ya-Wen Tsai Wan-Hsuan Hsu Po-Yu Huang Ming-Hui Chen Su-Yen Liu Mei-Chuan Lee Kuo-Chuan Hung Chih-Cheng Lai I-Ning Yang Source Type: research
Antivirals for the treatment of mild and moderate COVID-19 in South Africa
S Afr Med J. 2023 Dec 4;113(12):33. doi: 10.7196/SAMJ.2023.v113i12.1066.ABSTRACTWhile the majority of COVID-19 cases in South Africa (SA) are mild, patients with severe COVID-19 requiring hospitalisation present with significant morbidity and mortality and place a substantial burden on healthcare services. Given the low vaccine uptake in SA and other low- and middle-income countries in sub-Saharan Africa, the high prevalence of comorbidities and limited healthcare system capacity, evidence-based interventions that reduce the risk of severe disease and death should be considered for implementation. Several antiviral classes...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: R Perumal V Naidoo S Govender T N Gengiah Source Type: research
Clinical effectiveness of oral antiviral agents for treating non-hospitalized COVID-19 patients with chronic kidney disease
CONCLUSION: Oral antiviral agents could be associated with lower rates of all-cause hospitalization or death among non-hospitalized COVID-19 patients with CKD.PMID:38525673 | DOI:10.1080/14787210.2024.2334052 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - March 25, 2024 Category: Infectious Diseases Authors: Chia-Chen Chen Chi-Ya Huang Jheng-Yan Wu Mei-Yuan Liu Min-Hsiang Chuang Ting-Hui Liu Ya-Wen Tsai Wan-Hsuan Hsu Po-Yu Huang Ming-Hui Chen Su-Yen Liu Mei-Chuan Lee Kuo-Chuan Hung Chih-Cheng Lai I-Ning Yang Source Type: research
Antivirals for the treatment of mild and moderate COVID-19 in South Africa
S Afr Med J. 2023 Dec 4;113(12):33. doi: 10.7196/SAMJ.2023.v113i12.1066.ABSTRACTWhile the majority of COVID-19 cases in South Africa (SA) are mild, patients with severe COVID-19 requiring hospitalisation present with significant morbidity and mortality and place a substantial burden on healthcare services. Given the low vaccine uptake in SA and other low- and middle-income countries in sub-Saharan Africa, the high prevalence of comorbidities and limited healthcare system capacity, evidence-based interventions that reduce the risk of severe disease and death should be considered for implementation. Several antiviral classes...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: R Perumal V Naidoo S Govender T N Gengiah Source Type: research
