The Effect of Niacinamide Supplementation on Phosphate Concentrations in Dutch Dialysis Patients: a randomised, crossover trial
Hyperphosphatemia is a common complication in patients with kidney failure, despite the use of phosphate binders (PBs). Vitamin B3, either in the form of niacin or niacinamide (NAM), shows potential as “add-on” treatment to reduce serum phosphate concentrations in this population. NAM seems to lack many of the side-effects that are observed with niacin. The aim of this study was to investigate whether NAM is an effective and acceptable treatment in reducing serum phosphate concentrations in pa tients with kidney failure. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - March 14, 2024 Category: Urology & Nephrology Authors: Lara Schepers, Inez Jans, Gerda K. Pot, Arend-Jan Smilde, Julia M. Hofstra, Nicole M. de Roos Tags: Original Research Source Type: research
Metagenomic sequencing identified microbial species in the rumen and cecum microbiome responsible for niacin treatment and related to intramuscular fat content in finishing cattle
ConclusionThe results suggested that dietary manipulation, such as the supplementation of niacin, should be regarded as the effective and convenient way to improve IMF of castrated finishing steers by regulating rumen microbiome. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 11, 2024 Category: Microbiology Source Type: research
Macrod1 suppresses diabetic cardiomyopathy via regulating PARP1-NAD < sup > + < /sup > -SIRT3 pathway
This study identifies Macrod1 as a novel target for DCM treatment. Targeting the PARP1-NAD+-SIRT3 axis may open a novel avenue to development of new intervention strategies in DCM. Schematic illustration of macrod1 ameliorating diabetic cardiomyopathy oxidative stress via PARP1-NAD+-SIRT3 axis.PMID:38459256 | DOI:10.1038/s41401-024-01247-2 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - March 8, 2024 Category: Drugs & Pharmacology Authors: Yu-Ting Liu Hong-Liang Qiu Hong-Xia Xia Yi-Zhou Feng Jiang-Yang Deng Yuan Yuan Da Ke Heng Zhou Yan Che Qi-Zhu Tang Source Type: research
Macrod1 suppresses diabetic cardiomyopathy via regulating PARP1-NAD < sup > + < /sup > -SIRT3 pathway
This study identifies Macrod1 as a novel target for DCM treatment. Targeting the PARP1-NAD+-SIRT3 axis may open a novel avenue to development of new intervention strategies in DCM. Schematic illustration of macrod1 ameliorating diabetic cardiomyopathy oxidative stress via PARP1-NAD+-SIRT3 axis.PMID:38459256 | DOI:10.1038/s41401-024-01247-2 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - March 8, 2024 Category: Drugs & Pharmacology Authors: Yu-Ting Liu Hong-Liang Qiu Hong-Xia Xia Yi-Zhou Feng Jiang-Yang Deng Yuan Yuan Da Ke Heng Zhou Yan Che Qi-Zhu Tang Source Type: research
Macrod1 suppresses diabetic cardiomyopathy via regulating PARP1-NAD < sup > + < /sup > -SIRT3 pathway
This study identifies Macrod1 as a novel target for DCM treatment. Targeting the PARP1-NAD+-SIRT3 axis may open a novel avenue to development of new intervention strategies in DCM. Schematic illustration of macrod1 ameliorating diabetic cardiomyopathy oxidative stress via PARP1-NAD+-SIRT3 axis.PMID:38459256 | DOI:10.1038/s41401-024-01247-2 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - March 8, 2024 Category: Drugs & Pharmacology Authors: Yu-Ting Liu Hong-Liang Qiu Hong-Xia Xia Yi-Zhou Feng Jiang-Yang Deng Yuan Yuan Da Ke Heng Zhou Yan Che Qi-Zhu Tang Source Type: research
The Association of Milk and Multiple Food Avoidance with Growth Parameters in Infants and Children
CONCLUSION: Our study reveals that children with isolated CMA and multiple FA have a high nutrition gap, growth deceleration, and unbalanced bone metabolism, as shown by low blood calcium and elevated PTH levels.PMID:38447665 | DOI:10.1016/j.anai.2024.02.023 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 6, 2024 Category: Allergy & Immunology Authors: Cansin Sackesen Betul Buyuktiryaki Tugba Gokce Emre Gogebakan Beliz Su Gundogdu Sevgi Bilgic Eltan Elif Karakoc-Aydiner Ebru Arik Yilmaz Ceren Can Hilal Cengiz Ozlem Unlugedik Nevin Celik Said Incir Gul Yesiltepe Mutlu Damla Yildirim Hulya Gokmen Ozel Suk Source Type: research
The Association of Milk and Multiple Food Avoidance with Growth Parameters in Infants and Children
CONCLUSION: Our study reveals that children with isolated CMA and multiple FA have a high nutrition gap, growth deceleration, and unbalanced bone metabolism, as shown by low blood calcium and elevated PTH levels.PMID:38447665 | DOI:10.1016/j.anai.2024.02.023 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 6, 2024 Category: Allergy & Immunology Authors: Cansin Sackesen Betul Buyuktiryaki Tugba Gokce Emre Gogebakan Beliz Su Gundogdu Sevgi Bilgic Eltan Elif Karakoc-Aydiner Ebru Arik Yilmaz Ceren Can Hilal Cengiz Ozlem Unlugedik Nevin Celik Said Incir Gul Yesiltepe Mutlu Damla Yildirim Hulya Gokmen Ozel Suk Source Type: research
The Association of Milk and Multiple Food Avoidance with Growth Parameters in Infants and Children
CONCLUSION: Our study reveals that children with isolated CMA and multiple FA have a high nutrition gap, growth deceleration, and unbalanced bone metabolism, as shown by low blood calcium and elevated PTH levels.PMID:38447665 | DOI:10.1016/j.anai.2024.02.023 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 6, 2024 Category: Allergy & Immunology Authors: Cansin Sackesen Betul Buyuktiryaki Tugba Gokce Emre Gogebakan Beliz Su Gundogdu Sevgi Bilgic Eltan Elif Karakoc-Aydiner Ebru Arik Yilmaz Ceren Can Hilal Cengiz Ozlem Unlugedik Nevin Celik Said Incir Gul Yesiltepe Mutlu Damla Yildirim Hulya Gokmen Ozel Suk Source Type: research
High Niacin Levels May Raise Cardiovascular Disease Risk
Previous research has linked niacin, a type of B vitamin that is found in fortified flour and cereal, to lower levels of low-density lipoprotein (LDL) cholesterol. But taking niacin supplements has not led to lower risk of cardiovascular disease among people who also take statins —a discrepancy that researchers termed the niacin paradox. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 6, 2024 Category: General Medicine Source Type: research
Identification and validation of m6A-associated ferroptosis genes in renal clear cell carcinoma
We examined patients' immune profiles by risk score. Our prognostic genes predicted ccRCC treatment drugs. We found 37 DEMFRGs by comparing 1913 differentially expressed ccRCC genes to 202 m6A RNA methylation FRGs. Functional enrichment analysis showed that hypoxia-induced cell death and metabolism pathways were the most differentially expressed methylation functional regulating genes. Five prognostic genes were found by machine learning: TRIB3, CHAC1, NNMT, EGFR, and SLC1A4. An advanced renal cell carcinoma nomogram with age and risk score accurately predicted the outcome. These five prognostic genes were linked to variou...
Source: Cell Biology International - March 5, 2024 Category: Cytology Authors: Shuo Pang Shuo Zhao Yuxi Dongye Yidong Fan Jikai Liu Source Type: research
Identification and validation of m6A-associated ferroptosis genes in renal clear cell carcinoma
We examined patients' immune profiles by risk score. Our prognostic genes predicted ccRCC treatment drugs. We found 37 DEMFRGs by comparing 1913 differentially expressed ccRCC genes to 202 m6A RNA methylation FRGs. Functional enrichment analysis showed that hypoxia-induced cell death and metabolism pathways were the most differentially expressed methylation functional regulating genes. Five prognostic genes were found by machine learning: TRIB3, CHAC1, NNMT, EGFR, and SLC1A4. An advanced renal cell carcinoma nomogram with age and risk score accurately predicted the outcome. These five prognostic genes were linked to variou...
Source: Cell Biology International - March 5, 2024 Category: Cytology Authors: Shuo Pang Shuo Zhao Yuxi Dongye Yidong Fan Jikai Liu Source Type: research
Metabolic product of excess niacin is linked to increased risk of cardiovascular events
Nature Reviews Cardiology, Published online: 04 March 2024; doi:10.1038/s41569-024-01005-1A metabolic product of excess niacin promotes vascular inflammation in preclinical models and is associated with increased rates of major adverse cardiovascular events in humans. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 4, 2024 Category: Cardiology Authors: Gregory B. Lim Source Type: research
