The Power of Spirit – Join the Event
This post is an invitation for you on multiple levels. First, there’s the human-level invitation, which you’ll get by reading the words here. I’m hosting a live event on Zoom this weekend called The Power of Spirit, and I invite you to join us for it. It will be 3 hours each day, 10:00 AM to 1:00 PM Pacific Time on October 7 and 8, 2023.
The second level of this invitation is the spirit level. I’m writing this invitation while feeling very tuned in (thanks in part to a minidose of magic mushrooms this morning). As I’m writing, I can also feel some of the energy of the upcoming event flowing...
Source: Steve Pavlina's Personal Development Blog - October 6, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Abundance Announcements Creating Reality Emotions Lifestyle Relationships Source Type: blogs
Vitamins and Wound Healing
Wound healing is a complex biological process that involves inflammation, tissue formation, and tissue remodeling. Vitamin supplements can play a role in wound healing by supporting various aspects of the body’s natural healing processes. Here are some key vitamins and minerals that are important for wound healing:
Vitamin C: Vitamin C, also known as ascorbic acid, is essential for collagen synthesis, a protein that helps in the formation of skin, blood vessels, and connective tissue. Collagen is a crucial component of wound healing. Adequate vitamin C intake can promote tissue repair and reduce the risk of infectio...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - September 9, 2023 Category: Geriatrics Authors: Jeffrey M Levine Tags: Geriatric Medicine Pressure Injuries & Wound Care aging skin bedsore bedsores decubiti decubitus ulcer geriatrics gerontology Healthcare Quality Improving Medical Care Jeff Levine MD Jeffrey M Levine MD Nursing Homes pressure s Source Type: blogs
Exploring Psychedelic Microdosing
Recently I’ve taken an interest in microdosing, specifically with magic mushrooms. I began learning about it a few months ago and then learned even more at the Psychedelic Science conference in June. I’ve also had some recent conversations with people I know who’ve been microdosing, all of them reporting positive long-term effects. Most use mushrooms for microdosing, although one prefers microdosing with LSD.
The point of microdosing is to take a very small amount of a psychedelic substance in order to access some neurological gains without any obvious psychedelic effects or impairments. Those gains can be both sh...
Source: Steve Pavlina's Personal Development Blog - August 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Emotions Health Lifestyle Productivity Source Type: blogs
Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging.
A Popular Science Article on the State of Epigenetic Clocks
https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/
This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Small Lifespan Study of Combined Interventions
My attention was drawn recently to a small mouse life span study run by one of the groups that has been in the longevity community for a while now. It is interesting for testing combinations of interventions that have in the past been demonstrated to modestly slow aging in mice (such as rapamycin), or modestly improve aspects of cell function in old tissues (such as nicotinamide mononucleotide). Combinatorial studies are rare in academia and industry, for reasons that have a lot to do with (a) the perverse incentives produced by the existence of intellectual property, in that the rights to use specific interventions can be...
Source: Fight Aging! - September 26, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 22nd 2022
In conclusion, application of a multi-species bat epigenetic clock provides strong evidence that hibernation is associated with slower epigenetic ageing. The multi-species clock explains 94% of the variation in the chronological ages of both hibernating and non-hibernating big brown bats; however, the clock estimates are equal to or greater than the chronological age, suggesting big brown bats age slightly faster than a 'typical' bat, especially during the active period. (Source: Fight Aging!)
Source: Fight Aging! - August 21, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Small Trial of NMN Supplementation Shows Improved Muscle Function
Nicotinamide adenine dinucleotide (NAD) is central to mitochondrial function, but declines with age. Mitochondria are the power plants of the cell, producing chemical energy store molecules to power cellular processes. When mitochondria run down, everything suffers. Thus a great deal of attention has been given over the years to approaches that might help to boost mitochondrial function in old individuals: mitochondrially targeted antioxidants; increasing NAD levels; transplantation of mitochondria; copying mitochondrial genes into the nucleus to provide resistance against mitochondrial DNA damage. The small molecule appro...
Source: Fight Aging! - August 15, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
NAD+ Depletion Primes Cells for Inflammatory Behavior
Today's open access paper provides an interesting view on the age-related reduction in cellular NAD+ levels, a topic of interest in the longevity community these past years. Nicotinamide adenine dinucleotide (NAD) is an important piece of molecular machinery in the function of the electron transport chain in mitochondria. The primary role of mitochondria is to generate the chemical energy store molecule adenosine triphosphate (ATP), used to power the cell. NAD cycles between NAD+ and NADH during this process, and lower levels of NAD imply a growing dysfunction in cellular energy metabolism.
Separately, researchers h...
Source: Fight Aging! - January 18, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Nicotinamide Mononucleotide Supplement Adjusts the Gut Microbiome
In today's open access paper, the authors report on their investigation of the effects of nicotinamide mononucleotide (NMN) supplementation on the gut microbiome in mice. The gut microbiome changes with age, exhibiting a loss of helpful populations that produce metabolites necessary to health, and the growth in harmful populations that provoke chronic inflammation. Rejuvenating the aged gut microbiome via fecal microbiota transplantation from a young individual has been shown to improve health and extend life in short-lived species. Thus there is some interest in evaluating the effects on the gut microbiome produced by int...
Source: Fight Aging! - December 24, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Harvard Health Ad Watch: Mitochondria do a lot for you — what can you do for them?
Ever see an ad for a product that sounds awesome and wondered if it was really that good? That happened to me recently. “How are you taking care of your mitochondria?” an announcer asked. Well, there’s a question I’m not asked every day. And it’s one for which I had no answer.
Your cells are aging: Can supplements keep them young?
This ad and an accompanying website describe their products this way:
“a breakthrough range of nutritional solutions”
supplements that “work in harmony with your body’s natural processes to rewrite the rules of cell aging”
“helps activate the renewal of mitochondria in musc...
Source: Harvard Health Blog - March 30, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Healthy Aging Nutrition Vitamins and supplements Source Type: blogs
Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Conservative View of Targeting NAD+ Metabolism in Diseases of Aging
NAD+ metabolism in the context of aging and age-related disease is an area of some interest of late. NAD+ is involved in mitochondrial function, essential to cell and tissue function. The mechanisms of synthesizing and recycling NAD+ decline with age, and this might be an important contributing factor in the decline of mitochondrial function throughout the body. Certainly, the evidence in cells and animals suggests that mitochondrial function can be improved via restoration of youthful levels of NAD+.
Given that the available ways of manipulating NAD+ metabolism largely involve supplementation with vitamin B3 deriva...
Source: Fight Aging! - November 5, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
