Chronic Ethanol Intake Impairs Niacin Nutritional Status in Mice
J Nutr Sci Vitaminol (Tokyo). 2024;70(1):1-8. doi: 10.3177/jnsv.70.1.ABSTRACTNiacin is involved in many biological reactions relating energy metabolism, redox reactions, DNA repair and longevity. Since niacin deficiency has been reported in alcoholic patients, and niacin coenzyme NAD is used as substrate to dehydrogenate ethanol in the liver, ethanol consumption can be a factor to impair niacin nutritional status. We have recently established the niacin insufficient model mice using kynurenine 3-monooxygenase knock out (KMO-/-) mice with niacin-limited diet, which lack the de novo NAD synthesis pathway from tryptophan. To ...
Source: Journal of Nutritional Science and Vitaminology - February 28, 2024 Category: Nutrition Authors: Amane Mizutani Chihiro Goto Hidetsugu Fujigaki Yasuko Yamamoto Kuniaki Saito Sho Hatayama Tsutomu Fukuwatari Source Type: research
