Assessing the impacts of L-carnitine and modafinil on fatigue in Iraqi multiple sclerosis patients
J Adv Pharm Technol Res. 2023 Jul-Sep;14(3):226-228. doi: 10.4103/JAPTR.JAPTR_225_23. Epub 2023 Jul 28.ABSTRACTFatigue is a prevalent symptom experienced by individuals diagnosed with multiple sclerosis (MS), which greatly affects their daily activities and causes frustration and depression, thus affecting their lives and society. This can be prevented through the use of medicines such as L-carnitine and modafinil. The study aimed to examine the effect of L-carnitine and modafinil on fatigue and which one is better for MS patients. This was a clinical trial. This clinical trial was conducted in cooperation between Al-Kut U...
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Ahmed Hamza Al-Shammari Zainab A Abbood Hayder F Lateef Source Type: research
Idiopathic hypersomnia and Kleine-Levin syndrome
Rev Neurol (Paris). 2023 Sep 6:S0035-3787(23)01008-1. doi: 10.1016/j.neurol.2023.08.010. Online ahead of print.ABSTRACTIdiopathic hypersomnia (IH) and Kleine-Levin syndrome (KLS) are rare disorders of central hypersomnolence of unknown cause, affecting young people. However, increased sleep time and excessive daytime sleepiness (EDS) occur daily for years in IH, whereas they occur as relapsing/remitting episodes associated with cognitive and behavioural disturbances in KLS. Idiopathic hypersomnia is characterized by EDS, prolonged, unrefreshing sleep at night and during naps, and frequent morning sleep inertia, but rare sl...
Source: Revue Neurologique - September 8, 2023 Category: Neurology Authors: I Arnulf P Dodet S Leu-Semenescu J B Maranci Source Type: research
Modafinil ’s effects on cognition and sleep quality in affectively-stable patients with bipolar disorder: a pilot study
DiscussionResults suggest that modafinil is a relatively safe medication for affectively-stable BD patients when given with adjunctive mood stabilizers. Results are suggestive of cognitive benefit and improved daytime sleepiness, but worse sleep quality in those patients prescribed modafinil. A fully powered clinical trial is warranted with specific attention to the characteristics of patients who are most likely to benefit from treatment with modafinil and other methodological lessons learned from this pilot.Clinical trial registrationClinicalTrials.gov, identifier NCT01965925. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - September 4, 2023 Category: Psychiatry Source Type: research
Schichtarbeit
ZusammenfassungDie Schichtarbeitst örung oder das Schichtarbeitersyndrom bezeichnet einen übermäßig gestörten Schlaf, Müdigkeit und/oder ausgeprägte Schläfrigkeit über mindestens 3 Monate in engem zeitlichen Zusammenhang mit der Schichtarbeit und mit klinisch relevantem Leidensdruck. Dabei müssen nicht alle Schichtarbeitsz eiten betroffen sein. Die Diagnose erfolgt anhand von Schlaf-Wach-Tagebüchern über mindestens 14 Tage. Symptomatik und Schweregrad sind individuell stark unterschiedlich und können auch von Alter, Geschlecht oder Chronotyp abhängen. Die Schlafdauer ist bei kontinuierlicher Nachtschicht ni...
Source: Somnologie - Schlafforschung und Schlafmedizin - August 23, 2023 Category: Sleep Medicine Source Type: research
Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction
J Physiol. 2023 Aug 14. doi: 10.1113/JP282114. Online ahead of print.ABSTRACTThe secretion of insulin from β-cells in the islet of Langerhans is governed by a series of metabolic and electrical events, which can fail during the progression of type 2 diabetes (T2D). β-cells are electrically coupled via connexin-36 (Cx36) gap junction channels, which coordinates the pulsatile dynamics of [Ca2+ ] and insulin release across the islet. Factors such as pro-inflammatory cytokines and free fatty acids disrupt gap junction coupling under in vitro conditions. Here we test whether gap junction coupling and coordinated [Ca2+ ] dynam...
Source: The Journal of Physiology - August 14, 2023 Category: Physiology Authors: Joshua R St Clair Matthew J Westacott Jose Miranda Nikki L Farnsworth Vira Kravets Wolfgang E Schleicher JaeAnn M Dwulet Claire H Levitt Audrey Heintz Nurin W F Ludin Richard K P Benninger Source Type: research
Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction
J Physiol. 2023 Aug 14. doi: 10.1113/JP282114. Online ahead of print.ABSTRACTThe secretion of insulin from β-cells in the islet of Langerhans is governed by a series of metabolic and electrical events, which can fail during the progression of type 2 diabetes (T2D). β-cells are electrically coupled via connexin-36 (Cx36) gap junction channels, which coordinates the pulsatile dynamics of [Ca2+ ] and insulin release across the islet. Factors such as pro-inflammatory cytokines and free fatty acids disrupt gap junction coupling under in vitro conditions. Here we test whether gap junction coupling and coordinated [Ca2+ ] dynam...
Source: The Journal of Physiology - August 14, 2023 Category: Physiology Authors: Joshua R St Clair Matthew J Westacott Jose Miranda Nikki L Farnsworth Vira Kravets Wolfgang E Schleicher JaeAnn M Dwulet Claire H Levitt Audrey Heintz Nurin W F Ludin Richard K P Benninger Source Type: research
Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction
J Physiol. 2023 Aug 14. doi: 10.1113/JP282114. Online ahead of print.ABSTRACTThe secretion of insulin from β-cells in the islet of Langerhans is governed by a series of metabolic and electrical events, which can fail during the progression of type 2 diabetes (T2D). β-cells are electrically coupled via connexin-36 (Cx36) gap junction channels, which coordinates the pulsatile dynamics of [Ca2+ ] and insulin release across the islet. Factors such as pro-inflammatory cytokines and free fatty acids disrupt gap junction coupling under in vitro conditions. Here we test whether gap junction coupling and coordinated [Ca2+ ] dynam...
Source: The Journal of Physiology - August 14, 2023 Category: Physiology Authors: Joshua R St Clair Matthew J Westacott Jose Miranda Nikki L Farnsworth Vira Kravets Wolfgang E Schleicher JaeAnn M Dwulet Claire H Levitt Audrey Heintz Nurin W F Ludin Richard K P Benninger Source Type: research
Cognitive Rehabilitation for Patients with Schizophrenia: A Narrative Review of Moderating Factors, Strategies, and Outcomes
CONCLUSION: Cognitive symptoms, closely related to functional impairment, still remain a therapeutic challenge. Cognitive rehabilitation strategies are as yet the only treatment modality offering cognitive improvement to patients who struggle to recover.PMID:37525044 | DOI:10.1007/978-3-031-31978-5_17 (Source: Adv Data)
Source: Adv Data - July 31, 2023 Category: Epidemiology Authors: Maria Skokou Lambros Messinis Grigorios Nasios Philippos Gourzis Euthymios Dardiotis Source Type: research
Cognitive Rehabilitation for Patients with Schizophrenia: A Narrative Review of Moderating Factors, Strategies, and Outcomes
CONCLUSION: Cognitive symptoms, closely related to functional impairment, still remain a therapeutic challenge. Cognitive rehabilitation strategies are as yet the only treatment modality offering cognitive improvement to patients who struggle to recover.PMID:37525044 | DOI:10.1007/978-3-031-31978-5_17 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - July 31, 2023 Category: Research Authors: Maria Skokou Lambros Messinis Grigorios Nasios Philippos Gourzis Euthymios Dardiotis Source Type: research
Enrichment analysis of phenotypic data for drug repurposing in rare diseases
We present a proof-of-concept study aiming to assess Drug-induced Behavioral Signature Analysis (DBSA) as a systematic approach for drug discovery for rare disorders. We applied Drug-induced Behavioral Signature Analysis to high-content behavioral data obtained with SmartCube®, an automated in vivo phenotyping platform. The therapeutic potential of several dozen approved drugs was assessed for phenotypic reversal of the behavioral profile of a Huntington’s Disease (HD) murine model, the Q175 heterozygous knock-in mice. The in silico Drug-induced Behavioral Signature Analysis predictions were enriched for drugs known to ...
Source: Frontiers in Pharmacology - July 25, 2023 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 28, Pages 5270: Are There Prevalent Sex Differences in Psychostimulant Use Disorder? A Focus on the Potential Therapeutic Efficacy of Atypical Dopamine Uptake Inhibitors
igi Tanda
Psychostimulant use disorders (PSUD) affect a growing number of men and women and exert sizable public health and economic burdens on our global society. Notably, there are some sex differences in the onset of dependence, relapse rates, and treatment success with PSUD observed in preclinical and clinical studies. The subtle sex differences observed in the behavioral aspects of PSUD may be associated with differences in the neurochemistry of the dopaminergic system between sexes. Preclinically, psychostimulants have been shown to increase synaptic dopamine (DA) levels and may downregulate the dopamine transpor...
Source: Molecules - July 7, 2023 Category: Chemistry Authors: Melinda Hersey Mattingly K. Bartole Claire S. Jones Amy Hauck Newman Gianluigi Tanda Tags: Review Source Type: research
Sulfoxides in medicine
Curr Opin Chem Biol. 2023 Jun 10;76:102340. doi: 10.1016/j.cbpa.2023.102340. Online ahead of print.ABSTRACTIn the review, current status of sulfoxides on the pharmaceutical market is discussed. In the first part of the article, natural sulfoxides will be described with a special focus on sulforaphane and amanitin, a mushroom toxin which has been developed as payload in antibody drug conjugates in the possible cancer treatment. Controversies associated with the medical use of dimethylsulfoxide are briefly described in the next section. In the part devoted to PPIs, the benefits of using pure enantiomers (chiral switch) are d...
Source: Current Opinion in Chemical Biology - June 12, 2023 Category: Biochemistry Authors: El żbieta Wojaczyńska Jacek Wojaczy ński Source Type: research
Sulfoxides in medicine
Curr Opin Chem Biol. 2023 Jun 10;76:102340. doi: 10.1016/j.cbpa.2023.102340. Online ahead of print.ABSTRACTIn the review, current status of sulfoxides on the pharmaceutical market is discussed. In the first part of the article, natural sulfoxides will be described with a special focus on sulforaphane and amanitin, a mushroom toxin which has been developed as payload in antibody drug conjugates in the possible cancer treatment. Controversies associated with the medical use of dimethylsulfoxide are briefly described in the next section. In the part devoted to PPIs, the benefits of using pure enantiomers (chiral switch) are d...
Source: Current Opinion in Chemical Biology - June 12, 2023 Category: Biochemistry Authors: El żbieta Wojaczyńska Jacek Wojaczy ński Source Type: research
Use of psychoactive substances as a treatment for psychosis
CONCLUSION: The results obtained open up the possibility of having a guideline for clinicians/health professionals on the use of cannabidiol, modafinil and ketamine as adjunctive treatment for patients with psychotic conditions.PMID:37231549 | DOI:10.33588/rn.7611.2023077 (Source: Revista de Neurologia)
Source: Revista de Neurologia - May 26, 2023 Category: Neurology Authors: E Serrano-Jim énez M G de Lucas-Moreno Source Type: research
