Prevalence of the use of prescription stimulants as “study drugs” by UK university students: A brief report
ConclusionThere is a clear need for large-scale research in this area, using representative sampling and survey methods that protect student anonymity. (Source: Brain and Behavior)
Source: Brain and Behavior - February 13, 2024 Category: Neurology Authors: Ffinian Jones,
Philip M. Newton Tags: BRIEF REPORT Source Type: research
Perceived cognitive performance in off ‐prescription users of modafinil and methylphenidate: an online survey
ConclusionThese findings suggest that at least some reported off-prescription users of modafinil and methylphenidate may be seeking to reduce the impact of self-perceived poorer performance, particularly in forms of cognition that are likely to impact on self-directed or self-motivated work. (Source: Brain and Behavior)
Source: Brain and Behavior - February 5, 2024 Category: Neurology Authors: Rachel D. Teodorini,
Nicola Rycroft,
James H. Smith ‐Spark Tags: ORIGINAL ARTICLE Source Type: research
Comparison of effects of modafinil and caffeine on fatigue-vulnerable and fatigue-resistant aircrew after a limited period of sleep deprivation
This study, which is part of a larger randomized controlled clinical trial, aims to investigate the effect of caffeine and modafinil on fatigue-resistant and -vulnerable pilots. Methods: This study included 32 healthy employees of the Royal Netherlands Air Force, who completed three test days, separated by at least 7 days. After a regular work day, the subjects were randomly administered either 300 mg caffeine, 200 mg modafinil or placebo at midnight. Hereafter the subjects performed the psychomotor vigilance test (PVT), vigilance and tracking test (VigTrack) and Stanford sleepiness scale (SSS) six times until 8 a.m. the n...
Source: Physiological Research - January 23, 2024 Category: Physiology Authors: Yara Q Wingelaar-Jagt Thijs T Wingelaar Wim J Riedel Johannes G Ramaekers Source Type: research
Comparison of effects of modafinil and caffeine on fatigue-vulnerable and fatigue-resistant aircrew after a limited period of sleep deprivation
This study, which is part of a larger randomized controlled clinical trial, aims to investigate the effect of caffeine and modafinil on fatigue-resistant and -vulnerable pilots.Methods: This study included 32 healthy employees of the Royal Netherlands Air Force, who completed three test days, separated by at least 7 days. After a regular work day, the subjects were randomly administered either 300 mg caffeine, 200 mg modafinil or placebo at midnight. Hereafter the subjects performed the psychomotor vigilance test (PVT), vigilance and tracking test (VigTrack) and Stanford sleepiness scale (SSS) six times until 8 a.m. the...
Source: Frontiers in Physiology - January 8, 2024 Category: Physiology Source Type: research
Modafinil for severe fatigue in inflammatory bowel disease: a prospective case series
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 6, 2024 Category: Gastroenterology Authors: Calum D. Moulton, Allan H. Young, Ailsa L. Hart Tags: Research Letter Source Type: research
Correction to Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil
Clin Pharmacol Ther. 2023 Dec 18. doi: 10.1002/cpt.3142. Online ahead of print.NO ABSTRACTPMID:38108195 | DOI:10.1002/cpt.3142 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - December 18, 2023 Category: Drugs & Pharmacology Source Type: research
Correction to Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil
Clin Pharmacol Ther. 2023 Dec 18. doi: 10.1002/cpt.3142. Online ahead of print.NO ABSTRACTPMID:38108195 | DOI:10.1002/cpt.3142 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - December 18, 2023 Category: Drugs & Pharmacology Source Type: research
The Antinarcolepsy Drug Modafinil Reverses Hypoglycemia Unawareness and Normalizes Glucose Sensing of Orexin Neurons in Male Mice
Perifornical hypothalamus (PFH) orexin glucose-inhibited (GI) neurons that facilitate arousal have been implicated in hypoglycemia awareness. Mice lacking orexin exhibit narcolepsy, and orexin mediates the effect of the antinarcolepsy drug modafinil. Thus, hypoglycemia awareness may require a certain level of arousal for awareness of the sympathetic symptoms of hypoglycemia (e.g., tremors, anxiety). Recurrent hypoglycemia (RH) causes hypoglycemia unawareness. We hypothesize that RH impairs the glucose sensitivity of PFH orexin GI neurons and that modafinil normalizes glucose sensitivity of these neurons and restores hypogl...
Source: Diabetes - December 10, 2023 Category: Endocrinology Source Type: research
