Correction to Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil
Clin Pharmacol Ther. 2023 Dec 18. doi: 10.1002/cpt.3142. Online ahead of print.NO ABSTRACTPMID:38108195 | DOI:10.1002/cpt.3142 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - December 18, 2023 Category: Drugs & Pharmacology Source Type: research
The Antinarcolepsy Drug Modafinil Reverses Hypoglycemia Unawareness and Normalizes Glucose Sensing of Orexin Neurons in Male Mice
Perifornical hypothalamus (PFH) orexin glucose-inhibited (GI) neurons that facilitate arousal have been implicated in hypoglycemia awareness. Mice lacking orexin exhibit narcolepsy, and orexin mediates the effect of the antinarcolepsy drug modafinil. Thus, hypoglycemia awareness may require a certain level of arousal for awareness of the sympathetic symptoms of hypoglycemia (e.g., tremors, anxiety). Recurrent hypoglycemia (RH) causes hypoglycemia unawareness. We hypothesize that RH impairs the glucose sensitivity of PFH orexin GI neurons and that modafinil normalizes glucose sensitivity of these neurons and restores hypogl...
Source: Diabetes - December 10, 2023 Category: Endocrinology Source Type: research
Effect of psychostimulant medications on physical function in children with cerebral palsy: scoping review
Pediatr Res. 2023 Dec 9. doi: 10.1038/s41390-023-02933-3. Online ahead of print.ABSTRACTThe aim of this scoping review is to examine the extent and depth of the literature on effects of central nervous system (CNS) stimulant medications on physical function in children with cerebral palsy (CP). A systematic search for relevant peer-reviewed studies was conducted of PubMed, CINAHL, Cochrane, SPORTDiscus, Embase, & Scopus (January 2002 & August 2022). We included studies that examined the effects of CNS stimulants on physical function in children with CP. Four studies met our selection criteria. All studies explored ...
Source: Pediatric Research - December 9, 2023 Category: Pediatrics Authors: Anwar B Almutairi Naif Z Alrashdi Laura Vogtle Mansour M Alotaibi Source Type: research
Effect of psychostimulant medications on physical function in children with cerebral palsy: scoping review
Pediatr Res. 2023 Dec 9. doi: 10.1038/s41390-023-02933-3. Online ahead of print.ABSTRACTThe aim of this scoping review is to examine the extent and depth of the literature on effects of central nervous system (CNS) stimulant medications on physical function in children with cerebral palsy (CP). A systematic search for relevant peer-reviewed studies was conducted of PubMed, CINAHL, Cochrane, SPORTDiscus, Embase, & Scopus (January 2002 & August 2022). We included studies that examined the effects of CNS stimulants on physical function in children with CP. Four studies met our selection criteria. All studies explored ...
Source: Pediatric Research - December 9, 2023 Category: Pediatrics Authors: Anwar B Almutairi Naif Z Alrashdi Laura Vogtle Mansour M Alotaibi Source Type: research
EPH207 The Adverse Event Profiles of Modafinil in Approved Indications and Off-Label Use for Major Depressive Disorder: A Systematic Review and Meta-Analysis
Modafinil is an approved medication primarily used for treating excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. However, its usage extends beyond approved indications, including off-label use for major depressive disorder (MDD). This systematic review aims to comprehensively assess adverse events of both approved and unapproved applications of modafinil. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: J. Jung, J. Youm, A. Kim, J.K. Suh, H.Y. Kang Source Type: research
Selenium alleviates modafinil-induced neurobehavioral toxicity in rat via PI3K/Akt/mTOR/GSK3B signaling pathway and suppression of oxidative stress and apoptosis: in vivo and in silico study
In conclusion, Se could be used as a biologically effective antioxidant compound to protect from MOD neurobehavioral toxicity in Wistar rats by reversing behavioral alterations, inflammation, apoptosis, and oxidative injury.PMID:38015391 | DOI:10.1007/s11356-023-31093-4 (Source: Cell Research)
Source: Cell Research - November 28, 2023 Category: Cytology Authors: Shaimaa A Shehata Eman Kolieb Dina A Ali Shymaa Ahmed Maher Horeya Erfan Korayem Mahrous A Ibrahim Mohamed S Nafie Shimaa H Ameen Source Type: research
Selenium alleviates modafinil-induced neurobehavioral toxicity in rat via PI3K/Akt/mTOR/GSK3B signaling pathway and suppression of oxidative stress and apoptosis: in vivo and in silico study
In conclusion, Se could be used as a biologically effective antioxidant compound to protect from MOD neurobehavioral toxicity in Wistar rats by reversing behavioral alterations, inflammation, apoptosis, and oxidative injury.PMID:38015391 | DOI:10.1007/s11356-023-31093-4 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - November 28, 2023 Category: Environmental Health Authors: Shaimaa A Shehata Eman Kolieb Dina A Ali Shymaa Ahmed Maher Horeya Erfan Korayem Mahrous A Ibrahim Mohamed S Nafie Shimaa H Ameen Source Type: research
Psychosocial and pharmacologic interventions for problematic methamphetamine use: Findings from a scoping review of the literature
We examined evidence related to methamphetamine use, relapse, use of other substances, risk behaviors, mental health, harms, and retention. Figures, tables and descriptive synthesis were used to present findings from the identified literature. ResultsWe identified 2 SRs, one CPG, and 54 primary studies reported in 69 publications that met our eligibility criteria. Amongst SRs, one concluded that psychostimulants had no effect on methamphetamine abstinence or treatment retention while the other reported no effect of topiramate on cravings. The CPG strongly recommended psychosocial interventions as well as self-help and fami...
Source: PLoS One - October 11, 2023 Category: Biomedical Science Authors: Mona Hersi Source Type: research
A National Survey on Coma Epidemiology, Evaluation, and Therapy in India: Revisiting the Curing Coma Campaign Come Together Survey
ConclusionsDifferences from the global survey were noted regarding the following: traumatic brain injury being the most common etiology of coma in India, more frequent practice of sedation interruption, less frequent use of electroencephalography in India, rare use of pharmacological neurostimulants, and home being the most common discharge disposition in India. (Source: Neurocritical Care)
Source: Neurocritical Care - October 11, 2023 Category: Neurology Source Type: research
Recovery Mimicking "Ideal" CPAP Adherence Does Not Improve Wakefulness or Cognition in Chronic Murine Models of OSA: Effect of Wake-Promoting Agents
CONCLUSION: Chronic IH and SF induce EDS in young adult mice that is not ameliorated by recovery except when combined with either SOL or MOD. SOL, but not MOD, significantly improves IH-induced cognitive deficits. Thus, SOL emerges as a viable adjuvant medication for residual EDS in OSA along with its positive impact on cognition.PMID:37783638 | DOI:10.1016/j.arbres.2023.09.007 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 2, 2023 Category: Respiratory Medicine Authors: Mohammad Badran Clementine Puech Max B Barrow Alexandra R Runion David Gozal Source Type: research
Recovery Mimicking "Ideal" CPAP Adherence Does Not Improve Wakefulness or Cognition in Chronic Murine Models of OSA: Effect of Wake-Promoting Agents
CONCLUSION: Chronic IH and SF induce EDS in young adult mice that is not ameliorated by recovery except when combined with either SOL or MOD. SOL, but not MOD, significantly improves IH-induced cognitive deficits. Thus, SOL emerges as a viable adjuvant medication for residual EDS in OSA along with its positive impact on cognition.PMID:37783638 | DOI:10.1016/j.arbres.2023.09.007 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 2, 2023 Category: Respiratory Medicine Authors: Mohammad Badran Clementine Puech Max B Barrow Alexandra R Runion David Gozal Source Type: research
Recovery Mimicking "Ideal" CPAP Adherence Does Not Improve Wakefulness or Cognition in Chronic Murine Models of OSA: Effect of Wake-Promoting Agents
CONCLUSION: Chronic IH and SF induce EDS in young adult mice that is not ameliorated by recovery except when combined with either SOL or MOD. SOL, but not MOD, significantly improves IH-induced cognitive deficits. Thus, SOL emerges as a viable adjuvant medication for residual EDS in OSA along with its positive impact on cognition.PMID:37783638 | DOI:10.1016/j.arbres.2023.09.007 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 2, 2023 Category: Respiratory Medicine Authors: Mohammad Badran Clementine Puech Max B Barrow Alexandra R Runion David Gozal Source Type: research
Recovery Mimicking "Ideal" CPAP Adherence Does Not Improve Wakefulness or Cognition in Chronic Murine Models of OSA: Effect of Wake-Promoting Agents
CONCLUSION: Chronic IH and SF induce EDS in young adult mice that is not ameliorated by recovery except when combined with either SOL or MOD. SOL, but not MOD, significantly improves IH-induced cognitive deficits. Thus, SOL emerges as a viable adjuvant medication for residual EDS in OSA along with its positive impact on cognition.PMID:37783638 | DOI:10.1016/j.arbres.2023.09.007 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 2, 2023 Category: Respiratory Medicine Authors: Mohammad Badran Clementine Puech Max B Barrow Alexandra R Runion David Gozal Source Type: research
Recovery Mimicking "Ideal" CPAP Adherence Does Not Improve Wakefulness or Cognition in Chronic Murine Models of OSA: Effect of Wake-Promoting Agents
CONCLUSION: Chronic IH and SF induce EDS in young adult mice that is not ameliorated by recovery except when combined with either SOL or MOD. SOL, but not MOD, significantly improves IH-induced cognitive deficits. Thus, SOL emerges as a viable adjuvant medication for residual EDS in OSA along with its positive impact on cognition.PMID:37783638 | DOI:10.1016/j.arbres.2023.09.007 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 2, 2023 Category: Respiratory Medicine Authors: Mohammad Badran Clementine Puech Max B Barrow Alexandra R Runion David Gozal Source Type: research
