Recovery Mimicking "Ideal" CPAP Adherence Does Not Improve Wakefulness or Cognition in Chronic Murine Models of OSA: Effect of Wake-Promoting Agents

CONCLUSION: Chronic IH and SF induce EDS in young adult mice that is not ameliorated by recovery except when combined with either SOL or MOD. SOL, but not MOD, significantly improves IH-induced cognitive deficits. Thus, SOL emerges as a viable adjuvant medication for residual EDS in OSA along with its positive impact on cognition.PMID:37783638 | DOI:10.1016/j.arbres.2023.09.007

Source: Archivos de Bronconeumologia - October 2, 2023 Category: Respiratory Medicine Authors: Mohammad Badran Clementine Puech Max B Barrow Alexandra R Runion David Gozal Source Type: research