Correlation analysis of MRD positivity in patients with completely resected stage I-IIIA non-small cell lung cancer: a cohort study
ConclusionPostoperative ctDNA-MRD status in NSCLC patients exhibits correlations with the size of the primary tumor, lymph node metastasis, pathological subtype of lung adenocarcinoma, presence of vascular invasion, as well as TPS and CPS values for PD-L1 expression; in postoperative patients with MRD, the effectiveness of adjuvant EGFR-TKI targeted therapy exceeds that of chemotherapy, as evidenced by the elimination of ctDNA. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - July 21, 2023 Category: Cancer & Oncology Source Type: research
On Ultrasonographic Features of Mucinous Carcinoma with Micropapillary Pattern
(Source: Vascular Health and Risk Management)
Source: Vascular Health and Risk Management - July 17, 2023 Category: Cardiology Tags: Breast Cancer: Targets and Therapy Source Type: research
Association of Molecular Profiles and Mutational Status With Distinct Histological Lung Adenocarcinoma Subtypes. An Analysis of the LACE-Bio Data
CONCLUSION: High TMB has a prognostic role in resectable lung ADC. The high TMB group had a poor outcome with AC, suggesting that this group may be better served with immune checkpoint therapy.PMID:37438216 | DOI:10.1016/j.cllc.2023.06.002 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - July 12, 2023 Category: Cancer & Oncology Authors: Prashanth Ashok Kumar Maryam Karimi Alina Basnet Lesley Seymour Robert Kratzke Elizabeth Brambilla Thierry Le-Chevalier Jean-Charles Soria Ken Andr é Olaussen Siddhartha Devarakonda Ramaswamy Govindan Ming-Sound Tsao Frances A Shepherd Stefan Michiels St Source Type: research
Association of Molecular Profiles and Mutational Status With Distinct Histological Lung Adenocarcinoma Subtypes. An Analysis of the LACE-Bio Data
CONCLUSION: High TMB has a prognostic role in resectable lung ADC. The high TMB group had a poor outcome with AC, suggesting that this group may be better served with immune checkpoint therapy.PMID:37438216 | DOI:10.1016/j.cllc.2023.06.002 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 12, 2023 Category: Cancer & Oncology Authors: Prashanth Ashok Kumar Maryam Karimi Alina Basnet Lesley Seymour Robert Kratzke Elizabeth Brambilla Thierry Le-Chevalier Jean-Charles Soria Ken Andr é Olaussen Siddhartha Devarakonda Ramaswamy Govindan Ming-Sound Tsao Frances A Shepherd Stefan Michiels St Source Type: research
Association of Molecular Profiles and Mutational Status With Distinct Histological Lung Adenocarcinoma Subtypes. An Analysis of the LACE-Bio Data
CONCLUSION: High TMB has a prognostic role in resectable lung ADC. The high TMB group had a poor outcome with AC, suggesting that this group may be better served with immune checkpoint therapy.PMID:37438216 | DOI:10.1016/j.cllc.2023.06.002 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 12, 2023 Category: Cancer & Oncology Authors: Prashanth Ashok Kumar Maryam Karimi Alina Basnet Lesley Seymour Robert Kratzke Elizabeth Brambilla Thierry Le-Chevalier Jean-Charles Soria Ken Andr é Olaussen Siddhartha Devarakonda Ramaswamy Govindan Ming-Sound Tsao Frances A Shepherd Stefan Michiels St Source Type: research
Authentication of a survival nomogram for non-invasive micropapillary breast cancer
ConclusionOur novel prognostic nomogram for non-metastatic IMPC patients achieved a good level of accuracy in both cohorts and could be used to optimize the treatment based on the individual risk factors. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - July 12, 2023 Category: Cancer & Oncology Source Type: research
Stromal micropapillary pattern and CD44s expression predict worse outcome in lung adenocarcinomas with micropapillary pattern
CONCLUSIONS: Lung adenocarcinoma with micropapillary pattern indicated an unfavorable prognosis, which had two different pattens, AMP and SMP. SMP indicated a worse survival than AMP, and was an independent unfavorable factor for PFS. So, AMP/SMP subclassification is necessary to evaluate patient's prognosis. Furthermore, the absent expression of CD44s in micropapillary indicated shorter survival, especially in patients with EGFR mutation. Herein, CD44s may be a biological marker for micropapillary lung adenocarcinoma.PMID:37343380 | DOI:10.1016/j.prp.2023.154595 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - June 21, 2023 Category: Pathology Authors: Yiyun Fu Junmei Zha Qian Wu Yuan Tang Weiya Wang Qiao Zhou Lili Jiang Source Type: research
Stromal micropapillary pattern and CD44s expression predict worse outcome in lung adenocarcinomas with micropapillary pattern
CONCLUSIONS: Lung adenocarcinoma with micropapillary pattern indicated an unfavorable prognosis, which had two different pattens, AMP and SMP. SMP indicated a worse survival than AMP, and was an independent unfavorable factor for PFS. So, AMP/SMP subclassification is necessary to evaluate patient's prognosis. Furthermore, the absent expression of CD44s in micropapillary indicated shorter survival, especially in patients with EGFR mutation. Herein, CD44s may be a biological marker for micropapillary lung adenocarcinoma.PMID:37343380 | DOI:10.1016/j.prp.2023.154595 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - June 21, 2023 Category: Pathology Authors: Yiyun Fu Junmei Zha Qian Wu Yuan Tang Weiya Wang Qiao Zhou Lili Jiang Source Type: research
ASO Visual Abstract: A Multi-Institutional Study Analyzing the Combined Effect of Micropapillary Component and Consolidation-to-Tumor Ratio Exceeding 0.5 on the Prognosis for Pathologic Stage IA3 Lung Adenocarcinoma
Ann Surg Oncol. 2023 Jun 19. doi: 10.1245/s10434-023-13708-9. Online ahead of print.NO ABSTRACTPMID:37335350 | DOI:10.1245/s10434-023-13708-9 (Source: Ann Oncol)
Source: Ann Oncol - June 19, 2023 Category: Cancer & Oncology Authors: Shao-Jun Xu Jia-Hua Tu Hui Chen Ren-He Yan Rui-Qin Chen Chao Chen Cheng-Xiong You Zhi-Fan Zhang Shao-Bin Yu Shu-Chen Chen Source Type: research
ASO Visual Abstract: A Multi-Institutional Study Analyzing the Combined Effect of Micropapillary Component and Consolidation-to-Tumor Ratio Exceeding 0.5 on the Prognosis for Pathologic Stage IA3 Lung Adenocarcinoma
Ann Surg Oncol. 2023 Jun 19. doi: 10.1245/s10434-023-13708-9. Online ahead of print.NO ABSTRACTPMID:37335350 | DOI:10.1245/s10434-023-13708-9 (Source: Ann Oncol)
Source: Ann Oncol - June 19, 2023 Category: Cancer & Oncology Authors: Shao-Jun Xu Jia-Hua Tu Hui Chen Ren-He Yan Rui-Qin Chen Chao Chen Cheng-Xiong You Zhi-Fan Zhang Shao-Bin Yu Shu-Chen Chen Source Type: research
Metabolome sequencing reveals that PRMT1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis
This study identified the metabolic type-related features and intermediate transition morphology of IMPC, and the identification of potential targets of PRMT1 is expected to provide a basis for the precise diagnosis and treatment of breast IMPC.PMID:37301537 | DOI:10.1016/j.ajpath.2023.05.010 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - June 10, 2023 Category: Pathology Authors: Kailiang Wu Weidong Li Hanjiao Liu Chen Niu Qianqian Shi Jingyue Zhang Guangshen Gao Hui Sun Fangfang Liu Li Fu Source Type: research
Metabolome sequencing reveals that PRMT1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis
This study identified the metabolic type-related features and intermediate transition morphology of IMPC, and the identification of potential targets of PRMT1 is expected to provide a basis for the precise diagnosis and treatment of breast IMPC.PMID:37301537 | DOI:10.1016/j.ajpath.2023.05.010 (Source: Am J Pathol)
Source: Am J Pathol - June 10, 2023 Category: Pathology Authors: Kailiang Wu Weidong Li Hanjiao Liu Chen Niu Qianqian Shi Jingyue Zhang Guangshen Gao Hui Sun Fangfang Liu Li Fu Source Type: research
Metabolome sequencing reveals that PRMT1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis
This study identified the metabolic type-related features and intermediate transition morphology of IMPC, and the identification of potential targets of PRMT1 is expected to provide a basis for the precise diagnosis and treatment of breast IMPC.PMID:37301537 | DOI:10.1016/j.ajpath.2023.05.010 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - June 10, 2023 Category: Pathology Authors: Kailiang Wu Weidong Li Hanjiao Liu Chen Niu Qianqian Shi Jingyue Zhang Guangshen Gao Hui Sun Fangfang Liu Li Fu Source Type: research
Metabolome sequencing reveals that PRMT1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis
This study identified the metabolic type-related features and intermediate transition morphology of IMPC, and the identification of potential targets of PRMT1 is expected to provide a basis for the precise diagnosis and treatment of breast IMPC.PMID:37301537 | DOI:10.1016/j.ajpath.2023.05.010 (Source: Am J Pathol)
Source: Am J Pathol - June 10, 2023 Category: Pathology Authors: Kailiang Wu Weidong Li Hanjiao Liu Chen Niu Qianqian Shi Jingyue Zhang Guangshen Gao Hui Sun Fangfang Liu Li Fu Source Type: research
Metabolome sequencing reveals that PRMT1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis
This study identified the metabolic type-related features and intermediate transition morphology of IMPC, and the identification of potential targets of PRMT1 is expected to provide a basis for the precise diagnosis and treatment of breast IMPC.PMID:37301537 | DOI:10.1016/j.ajpath.2023.05.010 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - June 10, 2023 Category: Pathology Authors: Kailiang Wu Weidong Li Hanjiao Liu Chen Niu Qianqian Shi Jingyue Zhang Guangshen Gao Hui Sun Fangfang Liu Li Fu Source Type: research
