Invasive Micropapillary Carcinoma of the Breast
DefinitionBreast carcinoma with a prominent (pseudo) micropapillary patternDiagnostic CriteriaNumerous small pseudo-papillary clusters of cellsNo fibrovascular coresFrequent central lumen formation in clustersPeripherally located nuclei frequently bulge out with knobby appearance, "the hedgehog" tumorClusters surrounded by clear spacesOne or only a few clusters per spaceScant mucin rarely detectable in spacesSpaces surrounded by loose fibrocollagenous stromaFrequent high nuclear grade reported in some seriesFrequently has abundant eosinophilic cytoplasmFrequent lymphatic involvementOccasional psammoma bodiesAssociated DCIS...
Source: Oncopathology - March 1, 2014 Category: Cancer & Oncology Source Type: blogs
Invasive Micropapillary Carcinoma of the Breast
DefinitionBreast carcinoma with a prominent (pseudo) micropapillary patternDiagnostic CriteriaNumerous small pseudo-papillary clusters of cellsNo fibrovascular coresFrequent central lumen formation in clustersPeripherally located nuclei frequently bulge out with knobby appearance, "the hedgehog" tumorClusters surrounded by clear spacesOne or only a few clusters per spaceScant mucin rarely detectable in spacesSpaces surrounded by loose fibrocollagenous stromaFrequent high nuclear grade reported in some seriesFrequently has abundant eosinophilic cytoplasmFrequent lymphatic involvementOccasional psammoma bodiesAssociated DCIS...
Source: Oncopathology - March 1, 2014 Category: Pathologists Source Type: blogs
Invasive Micropapillary Carcinoma of the Breast
DefinitionBreast carcinoma with a prominent (pseudo) micropapillary patternDiagnostic CriteriaNumerous small pseudo-papillary clusters of cellsNo fibrovascular coresFrequent central lumen formation in clustersPeripherally located nuclei frequently bulge out with knobby appearance, "the hedgehog" tumorClusters surrounded by clear spacesOne or only a few clusters per spaceScant mucin rarely detectable in spacesSpaces surrounded by loose fibrocollagenous stromaFrequent high nuclear grade reported in some seriesFrequently has abundant eosinophilic cytoplasmFrequent lymphatic involvementOccasional psammoma bodiesAssociated DCIS...
Source: Oncopathology - March 1, 2014 Category: Cancer & Oncology Source Type: blogs
Micropapillary Carcinoma of the Breast
-Micropapillary breast carcinoma (or invasive micropapillary carcinoma IMPC) is a type of otherwise 'typical' invasive ductal carcinoma which exhibits a unique and characteristic growth pattern. -Invasive micropapillary breast carcinoma is a very aggressive form of breast cancer, with a very high rate of lymph node metastasis.(The rate of lymph node involvement is estimated at between 75% and 100%).-Skin invovlement (skin retraction) is another occassional feature of invasive micropapillary carcinoma of the breast, and is observed in about 20-23% of all cases.Histological aspects of invasive micropapillary carcinoma o...
Source: Oncopathology - October 24, 2012 Category: Cancer & Oncology Tags: breast breast cancer carcinoma micropapillary poor prognosis Source Type: blogs
Minimal Reporting Guidelines for the Treatment of Cancer Patients
Minimal Reporting Guidelines for the Treatment of Cancer Patients As laboratory physicians, our contribution to patient care is knowledge: this is the starting point from which all informed therapeutic intervention proceeds. How that knowledge is obtained and communicated is the art and science of our profession. These minimal diagnostic guidelines are designed to be used as an aid, not a constraint, in that process. The guidelines are presented in a specific format out of necessity, but any format that effectively communicates the necessary information in a given patho...
Source: Oncopathology - September 5, 2011 Category: Cancer & Oncology Source Type: blogs
High Grade Prostatic Intraepithelial Neoplasia (HGPIN)
:Common questions asked about HGPIN are :-How do we as pathologists make these diagnoses?-What do they mean for the patient in terms of cancer risk?-What is/are the optimal strategies for follow-up so that if cancer does eventually develop it is caught at an early, curable stage?Pathology criteria for diagnosis of HGPIN:-Architecturally benign acini/ducts lined by atypical cells.-These cells show large nuclei and prominent nucleoli (cytologic features of carcinoma).-Generally at least 10% of the luminal cells should show these features to make the diagnosis. Diagnosis of HGPIN has been shown to be reproducible. Low grade p...
Source: Oncopathology - March 2, 2010 Category: Cancer & Oncology Tags: High Grade Prostatic Intraepithelial Neoplasia (HGPIN) Source Type: blogs
