Bladder cancer variants — one disease with many faces
Nature Reviews Urology, Published online: 22 April 2024; doi:10.1038/s41585-024-00886-8Bladder cancer progression to microscopically distinct variants such as sarcomatoid, small cell, micropapillary and plasmacytoid is associated with more aggressive clinical behaviour than conventional carcinoma. Advances in molecular profiling led to the identification of molecular subtypes of bladder cancer and provided insights into disease progression to aggressive variants. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 22, 2024 Category: Urology & Nephrology Authors: Bogdan Czerniak Source Type: research
Primary salivary duct carcinoma of the lung: clinicopathological features, diagnosis and practical challenges
Conclusions
LSDC is a highly rare malignant tumour. The distinctive architecture of in situ carcinoma and tumour cells expressing AR can provide diagnostic indications for LSDC. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Li, S., Hou, L., Huang, Y., Wu, W., Wu, C., Zhang, L. Tags: Original research Source Type: research
Log odds of positive lymph nodes (LODDS)-based novel nomogram for survival estimation in patients with invasive micropapillary carcinoma of the breast
This study... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - April 18, 2024 Category: Research Authors: Xiangdi Meng, Furong Hao, Nan Wang, Peiyan Qin, Zhuojun Ju and Daqing Sun Tags: Research Source Type: research
Computed tomography-based 3D convolutional neural network deep learning model for predicting micropapillary or solid growth pattern of invasive lung adenocarcinoma
ConclusionThe CT-based DL model performed well as a noninvasive screening tool capable of reliably detecting and distinguishing the subtypes of ILADC, even in small-sized tumors. (Source: La Radiologia Medica)
Source: La Radiologia Medica - March 21, 2024 Category: Radiology Source Type: research
Significance of ZO-1, an Intercellular Adhesion Molecule, as a Prognostic Marker in Lung Adenocarcinoma
Tokai J Exp Clin Med. 2024 Apr 20;49(1):1-8.ABSTRACTIn epithelial tissues, intercellular adhesion structures are formed between adjacent cells via intercellular adhesion factors, such as zonula occludens (ZO-1), to maintain the structure and function of tissues and organs, thereby contributing to homeostasis. Epithelial cells are polarized into apical and basal regions by tight junctions (TJs), a type of intercellular adhesion structure, and thus, their intracellular organelles are asymmetrically distributed. Normal epithelial cells maintain their cellular function by controlling cytoskeletal reorganization, motility, and ...
Source: Clinical Lung Cancer - March 20, 2024 Category: Cancer & Oncology Authors: Takaaki Tsuboi Tomohiko Matsuzaki Susumu Takekoshi Kei Nakano Kie Shioyama Tomoki Higeta Kazuhiro Matsuo Takashi Ishihara Masaya Ohara Kenei Nakazato Ryota Masuda Masayuki Iwazaki Source Type: research
Predicting individual outcomes after radical cystectomy in urothelial variants with Cancer of the Bladder Risk Assessment (COBRA) score
ConclusionsIn our study, the COBRA score proved an effective risk stratification tool for urothelial histological variants, especially for the micropapillary urothelial variant. It may be helpful in the prognosis evaluation of UV patients after radical cystectomy. (Source: World Journal of Urology)
Source: World Journal of Urology - March 14, 2024 Category: Urology & Nephrology Source Type: research
Emerging and under-recognised patterns of colorectal carcinoma morphologies: a comprehensive review
J Clin Pathol. 2024 Mar 6:jcp-2023-208816. doi: 10.1136/jcp-2023-208816. Online ahead of print.ABSTRACTWhile the overwhelming majority of colorectal carcinomas (CRC) are diagnosed as adenocarcinoma not otherwise specified, there are numerous under-recognised morphologic patterns of CRC. These patterns are recognised by the WHO, appear in reporting manuals for the American Joint Committee of Cancer, and/or are listed on synoptic reports, while many other variants have either fallen out of favour or are emerging as future bona fide patterns. Herein, we discuss 13 variants: serrated adenocarcinoma, micropapillary adenocarcino...
Source: Clinical Colorectal Cancer - March 6, 2024 Category: Cancer & Oncology Authors: Yuho Ono Osman Yilmaz Source Type: research
The role of neoadjuvant chemotherapy for patients with variant histology muscle invasive bladder cancer undergoing robotic cystectomy: Data from the International Robotic Cystectomy Consortium
CONCLUSION: Our data showed no significant difference in OS, RFS, or DSS for patients with VH MIBC cancer who received NAC before RARC. Patients with the squamous variant who received NAC had more pathologic downstaging compared to those who did not. The role of NAC among patients with VH is yet to be defined. Results were limited by small number in each individual group and lack of exact proportion of VH.PMID:38429124 | DOI:10.1016/j.urolonc.2024.01.002 (Source: Urologic Oncology)
Source: Urologic Oncology - March 1, 2024 Category: Urology & Nephrology Authors: Ian Cooke Nassib Abou Heidar Abdul Wasay Mahmood Ali Ahmad Zhe Jing Michael St öckle Andrew A Wagner Morgan Roupret Eric Kim Nikhil Vasdev Derya Balbay Koon Ho Rha Ahmed Aboumohamed Prokar Dasgupta Thomas J Maatman Lee Richstone Peter Wiklund Franco Gabo Source Type: research
The role of neoadjuvant chemotherapy for patients with variant histology muscle invasive bladder cancer undergoing robotic cystectomy: Data from the International Robotic Cystectomy Consortium
CONCLUSION: Our data showed no significant difference in OS, RFS, or DSS for patients with VH MIBC cancer who received NAC before RARC. Patients with the squamous variant who received NAC had more pathologic downstaging compared to those who did not. The role of NAC among patients with VH is yet to be defined. Results were limited by small number in each individual group and lack of exact proportion of VH.PMID:38429124 | DOI:10.1016/j.urolonc.2024.01.002 (Source: Urologic Oncology)
Source: Urologic Oncology - March 1, 2024 Category: Urology & Nephrology Authors: Ian Cooke Nassib Abou Heidar Abdul Wasay Mahmood Ali Ahmad Zhe Jing Michael St öckle Andrew A Wagner Morgan Roupret Eric Kim Nikhil Vasdev Derya Balbay Koon Ho Rha Ahmed Aboumohamed Prokar Dasgupta Thomas J Maatman Lee Richstone Peter Wiklund Franco Gabo Source Type: research
Prediction of solid and micropapillary components in lung invasive adenocarcinoma: radiomics analysis from high-spatial-resolution CT data with 1024 matrix
ConclusionTwo texture features (Coefficient Variation and Entropy) were significant indicators to predict solid and micropapillary components in lung invasive adenocarcinoma. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - February 28, 2024 Category: Radiology Source Type: research
Survival benefit of adjuvant chemotherapy after resection of Stage I lung adenocarcinoma containing micropapillary components
ConclusionAmong patients with stage I lung adenocarcinoma with MIP components, those who received ACT showed significant survival benefits compared to those without ACT. Patients with lung adenocarcinoma with MIP components could benefit from ACT when the MIP was ≥1%. (Source: Cancer Medicine)
Source: Cancer Medicine - February 24, 2024 Category: Cancer & Oncology Authors: Ying Li,
Junfeng Zhao,
Ying Zhao,
Ruyue Li,
Xue Dong,
Xiujing Yao,
Zhongshuo Xia,
Yali Xu,
Yintao Li Tags: RESEARCH ARTICLE Source Type: research
Invasive micropapillary urothelial carcinoma of the renal pelvis presenting as nonfunctional kidney: A unique presentation and review of the literature
We reported an additional case of micropapillary urothelial carcinoma of the renal pelvis, literature review, and discussed the differential diagnosis. Immunonegativity of p63 in the micropapillary component was an additional finding.PMID:38394422 | DOI:10.4103/ijpm.ijpm_346_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Mohammed Shahin Sagar R Tripathy Prasant Nayak Prasanna Ram Pavithra Ayyanar Source Type: research
Invasive micropapillary urothelial carcinoma of the renal pelvis presenting as nonfunctional kidney: A unique presentation and review of the literature
We reported an additional case of micropapillary urothelial carcinoma of the renal pelvis, literature review, and discussed the differential diagnosis. Immunonegativity of p63 in the micropapillary component was an additional finding.PMID:38394422 | DOI:10.4103/ijpm.ijpm_346_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Mohammed Shahin Sagar R Tripathy Prasant Nayak Prasanna Ram Pavithra Ayyanar Source Type: research
Invasive micropapillary urothelial carcinoma of the renal pelvis presenting as nonfunctional kidney: A unique presentation and review of the literature
We reported an additional case of micropapillary urothelial carcinoma of the renal pelvis, literature review, and discussed the differential diagnosis. Immunonegativity of p63 in the micropapillary component was an additional finding.PMID:38394422 | DOI:10.4103/ijpm.ijpm_346_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Mohammed Shahin Sagar R Tripathy Prasant Nayak Prasanna Ram Pavithra Ayyanar Source Type: research
Invasive micropapillary urothelial carcinoma of the renal pelvis presenting as nonfunctional kidney: A unique presentation and review of the literature
We reported an additional case of micropapillary urothelial carcinoma of the renal pelvis, literature review, and discussed the differential diagnosis. Immunonegativity of p63 in the micropapillary component was an additional finding.PMID:38394422 | DOI:10.4103/ijpm.ijpm_346_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Mohammed Shahin Sagar R Tripathy Prasant Nayak Prasanna Ram Pavithra Ayyanar Source Type: research
