Evaluation of a Beta-blocker - Edema - Loop Diuretic Prescribing Cascade: A Prescription Sequence Symmetry Analysis
CONCLUSIONS: We observed excess use of loop diuretics following beta-blocker initiation that was only partially explained by secular trends or hypertension progression.PMID:35106529 | DOI:10.1093/ajh/hpac013 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - February 2, 2022 Category: Cardiology Authors: Scott Martin Vouri Earl J Morris Xinyi Jiang Ann-Kathrin Hofer Stephan Schmidt Carl Pepine Almut G Winterstein Steven M Smith Source Type: research
Evaluation of a Beta-blocker - Edema - Loop Diuretic Prescribing Cascade: A Prescription Sequence Symmetry Analysis
CONCLUSIONS: We observed excess use of loop diuretics following beta-blocker initiation that was only partially explained by secular trends or hypertension progression.PMID:35106529 | DOI:10.1093/ajh/hpac013 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - February 2, 2022 Category: Cardiology Authors: Scott Martin Vouri Earl J Morris Xinyi Jiang Ann-Kathrin Hofer Stephan Schmidt Carl Pepine Almut G Winterstein Steven M Smith Source Type: research
Evaluation of a Beta-blocker - Edema - Loop Diuretic Prescribing Cascade: A Prescription Sequence Symmetry Analysis
CONCLUSIONS: We observed excess use of loop diuretics following beta-blocker initiation that was only partially explained by secular trends or hypertension progression.PMID:35106529 | DOI:10.1093/ajh/hpac013 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - February 2, 2022 Category: Cardiology Authors: Scott Martin Vouri Earl J Morris Xinyi Jiang Ann-Kathrin Hofer Stephan Schmidt Carl Pepine Almut G Winterstein Steven M Smith Source Type: research
Evaluation of a Beta-blocker - Edema - Loop Diuretic Prescribing Cascade: A Prescription Sequence Symmetry Analysis
CONCLUSIONS: We observed excess use of loop diuretics following beta-blocker initiation that was only partially explained by secular trends or hypertension progression.PMID:35106529 | DOI:10.1093/ajh/hpac013 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - February 2, 2022 Category: Cardiology Authors: Scott Martin Vouri Earl J Morris Xinyi Jiang Ann-Kathrin Hofer Stephan Schmidt Carl Pepine Almut G Winterstein Steven M Smith Source Type: research
Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension
CONCLUSIONS: The combination of investigated herbs and MT had a beneficial effect on hypertension. However, the concurrent administration of drugs, particularly those predominantly cleared through CYP450 2D6-catalyzed metabolism, with the three investigated herbs should be considered with caution.PMID:34392777 | DOI:10.1080/13880209.2021.1961817 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 16, 2021 Category: Drugs & Pharmacology Authors: Yousef A Bin Jardan Abdul Ahad Mohammad Raish Mohd Aftab Alam Abdullah M Al-Mohizea Fahad I Al-Jenoobi Source Type: research
Overdose and Alcohol Sensitive Immediate Release System (OASIS) for Deterring Accidental Overdose or Abuse of Drugs.
Abstract
Death from an accidental or intentional overdose of sleeping tablets has increased exponentially in the USA. Furthermore, the simultaneous consumption of sleeping tablets with alcoholic beverages not only intensifies the effect of sleeping tablets but also leads to blackouts, sleepwalking, and death in many cases. In this article, we proposed a unique and innovative technology to prevent multi-tablet and alcohol-associated abuse of sleeping tablet. Agonist- and antagonist-loaded polymeric filaments of appropriate Eudragit® polymers were prepared using hot melt extrusion. Metoprolol tartrate and h...
Source: AAPS PharmSciTech - November 25, 2020 Category: Drugs & Pharmacology Authors: Patki M, Palekar S, Nukala PK, Vartak R, Patel K Tags: AAPS PharmSciTech Source Type: research
Persistent Hyperinsulinemia Following High-Dose Insulin Therapy: A Case Report.
CONCLUSION: The kinetics of insulin following discontinuation of high-dose insulin therapy are largely unknown, but supraphysiologic insulin levels persist for some time following therapy; this may allow for simple discontinuation rather than titration of insulin at the end of therapy. Dextrose replacement is frequently needed; although the duration is often difficult to predict, prolonged infusions may not be necessary.
PMID: 32656624 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - July 10, 2020 Category: Toxicology Authors: Corcoran JN, Jacoby KJ, Olives TD, Bangh SA, Cole JB Tags: J Med Toxicol Source Type: research
Assessment of the safety of intravitreal injection of metoprolol tartrate in rabbits
ConclusionsThe intravitreal use of metoprolol at 50 and 100 µg dosages does not cause short-term retinal toxicity in rabbits. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 3, 2020 Category: Opthalmology Source Type: research
Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods.
Authors: Ouyang H, Shen J, Huang X, Ma W, Jia Q, Yao G, Tang Z, Zhang D, Sun M, Teye Azietaku J, Hao J, Gao X, Chang Y, He J
Abstract
Naoxintong capsule (NXT), a prescribed Chinese medicine, has been used clinically for more than 20 years and is widely received by patients. We determined five probe drugs, namely, omeprazole (CYP2C19), midazolam (CYP3A4), phenacetin (CYP1A2), tolbutamide (CYP2C9), and dextromethorphan (CYP2D6) to study the potential influences of NXT on the activities of CYP enzymes and assessed the pharmacokinetics effect of NXT on metoprolol tartrate in rat plasma. The study showed that A...
Source: Evidence-based Complementary and Alternative Medicine - November 1, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats.
Abstract
A high-throughput HPLC-MS/MS method was developed and validated for the determination of four antihypertensive drugs including metoprolol tartrate, hydrochlorothiazide, nifedipine, and valsartan in rat plasma. The Sprague-Dawley rats were randomly divided into three groups: A Group: gastric-administration of metoprolol tartrate, hydrochlorothiazide, nifedipine, or valsartan; B Group: a single intravenous injection of SXT, then dosing as the A group; C Group: daily injection of SXT through the tail vein for 8 consecutive days and dosing as the A group on the eighth day. For metoprolol tartrate and ...
Source: Biomed Res - September 1, 2019 Category: Research Authors: Wei J, Ma W, Yao G, Jia Q, Cheng X, Ouyang H, Chang Y, Chen X, He J Tags: Biomed Res Int Source Type: research
Quantitative analysis of 3-isopropylamino-1,2-propanediol as a degradation product of metoprolol in pharmaceutical dosage forms by HILIC-CAD
Publication date: Available online 28 August 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Qun Xu, Shane TanAbstractAryloxypropanolamine is an essential structural scaffold for a variety of β-adrenergic receptor antagonists such as metoprolol. Molecules with such a structural motif tend to degrade into α, β–hydroxypropanolamine impurities via a radical–initiated oxidation pathway. These impurities are typically polar and nonchromophoric, and are thus often overlooked using traditional reversed phase chromatography and UV detection. In this work, stress testing of metoprolol confirmed the generation of 3-i...
Source: Journal of Pharmaceutical Analysis - August 29, 2019 Category: Drugs & Pharmacology Source Type: research
Pore size effect on adsorption and release of metoprolol tartrate in mesoporous silica: Experimental and molecular simulation studies
In this study, two MCF-26 type MSNs were prepared with pore size of 11 or 15 nm, and used to conduct MPT release in comparison with MCM-41 and SBA-15. Both molecular simulation and MPT release experiments were performed to identify the pore size effect on adsorption and diffusion (release) of MPT in these MSNs. Finally, a kind of pH-sensitive MPT drug delivery system was obtained by coating the chosen MCF-26@MPT with an enteric polymer, which might find promising application in treating morning hypertension attack by orally administrating the drug delivery system before bedtime. (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - March 23, 2019 Category: Materials Science Source Type: research
Advancing USP compendial methods for fixed dose combinations: a case study of metoprolol tartrate and hydrochlorothiazide tablets
Publication date: Available online 28 December 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Qun XuAbstractThe current United States Pharmacopeia–National Formulary (USP–NF) includes more than 250 monographs of fixed dose combinations (FDCs), and some of them need to be updated due to incompleteness of impurity profiles and obsolescence of analytical methodologies. A case study of metoprolol tartrate and hydrochlorothiazide tablets is presented to summarize challenges encountered during the USP monograph modernization initiative of FDCs and to highlight an “adoption and adaptation” approach employed for ...
Source: Journal of Pharmaceutical Analysis - December 29, 2018 Category: Drugs & Pharmacology Source Type: research
Detection of potential look-alike/sound-alike medication errors using Veterans Affairs administrative databases.
CONCLUSION: Through the use of administrative databases, potential LASA errors that could be reviewed for an actual error via chart review were identified. While a high rate of potential LASA errors was detected, the number of actual errors identified was low.
PMID: 30257842 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - September 29, 2018 Category: Drugs & Pharmacology Authors: Zacher JM, Cunningham FE, Zhao X, Burk ML, Moore VR, Good CB, Glassman PA, Aspinall SL Tags: Am J Health Syst Pharm Source Type: research
